The aim of this study was to investigate the effects of calcium hydroxide (Ca(OH)₂) and propolis intracanal medicaments on bond strength of AH Plus to root dentin. After chemomechanical instrumentation using Revo-S rotary system, three groups of root canal specimens were prepared: 10 root canals were left untreated as controls (G1), 10 received Ca(OH)₂ intracanal medicament (G2), and another 10 received propolis intracanal medicament (G3). Canals were obturated with AH Plus and gutta-percha. After bond strength evaluation using micro push-out test, data were analyzed using ANOVA and Tamhane’s test (p=0.05). At coronal and middle thirds, there were no significant differences in bond strength among the three groups (p>0.05). At apical third, G3 was significantly superior to G2 (p<0.05) and G1 (p<0.05), but there was no significant difference between G2 and G1 (p>0.05). Therefore, when AH Plus was used as the sealer in endodontic treatments, its combined use with propolis as an intracanal medicament seemed to result in favorable sealer-dentin interfacial bond strength.