Original ArticleSurgical Pathology of Carcinoid Heart Disease: A Study of 139 Valves From 75 Patients Spanning 20 Years
Section snippets
PATIENTS AND METHODS
The protocol for this study was approved by the Mayo Foundation Institutional Review Board. Medical records, operative reports, and surgical specimens were reviewed from all patients who had undergone cardiac surgery on native cardiac valves for carcinoid heart disease at Mayo Clinic, Rochester, Minn, during the 20 years from July 1, 1980, to June 30, 2000.
For each patient, age and sex were recorded from the medical history, as were the dates of diagnosis of carcinoid syndrome, carcinoid heart
RESULTS
Among 79 patients who underwent valvular surgery for carcinoid heart disease, 75 had adequate surgical specimens. The 75 operations included procedures on 156 valves and excision of tissue from 139 (73 tricuspid, 55 pulmonary, 6 mitral, and 5 aortic). For 17 valves (13 pulmonary, 2 tricuspid, 1 mitral, and 1 aortic), repair was accomplished without removal of tissue. Thus, the study group included 139 valves from 75 patients. Some cases have been reported previously as part of larger series
DISCUSSION
Most of the information concerning the valvular pathology of carcinoid heart disease is derived from 40 cases reported in 7 autopsy series (Table 3),6, 7, 8, 9, 10, 11, 12 of which 21 cases appeared in 3 publications from the National Institutes of Health.9, 11, 12 Numerous case reports and a surgical series of 3 patients have also provided insights about the disease process.13 The current investigation uniquely reviews and quantitates the surgical pathology of carcinoid heart disease in 139
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