EDITORIALWhat Is a NICE-SUGAR for Patients in the Intensive Care Unit?
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Cited by (42)
Perioperative Glycemic Control
2012, Anesthesiology ClinicsCitation Excerpt :Furnary and colleagues,15 in a prospective investigation, showed a 66% reduction in sternal wound infection, whereas a retrospective investigation supported hyperglycemia as an independent predictor of postoperative infection in diabetic patients undergoing cardiac surgery.14 Although investigations of intensive glycemic control outside the perioperative and critical care populations are sparse, 1 prospective study in 834 patients undergoing surgical clipping of cerebral aneurysm after subarachnoid hemorrhage found a reduced infection rate in the intensive glycemic control group (BG 80–120 mg/dL) compared with conventional therapy (BG 80–220 mg/dL).72 However, the investigators found no improvement in mortality or other morbidity parameters (eg, vasospasm).
The need for increased vigilance in managing hyperglycaemia during acute coronary syndrome in the emergency department: An introduction to the evidence
2011, Australasian Emergency Nursing JournalCitation Excerpt :Goyal et al.58 concluded that clinicians should not be overly concerned about inducing hypoglycaemia as it did not seem to be a direct mediator of adverse outcomes in ACS. The potential to reduce mortality and morbidity after ACS with intense glycaemic control, although challenged,48,51 is clinically significant according to available scientific literature.5,7 It seems likely that in the future, ED personnel will be asked to participate in implementation of IIT for patients with ACS found to have stress hyperglycaemia.
Glycemic control in the ICU
2011, ChestCitation Excerpt :In addition, recent hypoglycemia can reduce autonomic responses and defenses against subsequent hypoglycemia. Whether these mechanisms played a role in the results of the NICE-SUGAR or other trials is currently unclear, but the available data suggest that avoiding even mild hypoglycemia is advisable.49 Some of the patient groups at risk of hypoglycemia have been identified: These include patients with diabetes mellitus (DM), septic shock, and renal insufficiency, particularly patients treated with continuous renal replacement therapy; those being treated with mechanical ventilation and inotropic agents; those with higher severity of illness; and those being treated with IIT.50–52
Hypoglycemia in sepsis: Biomarker, mediator, or both?
2011, Critical Care Medicine