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CC BY-NC-ND 4.0 · Eur J Dent 2015; 09(04): 614-619
DOI: 10.4103/1305-7456.172621
Review Article
Dental Investigation Society

Allergic effects of the residual monomer used in denture base acrylic resins

Haroon Rashid
1   Department of Prosthodontics, College of Dentistry, Ziauddin University, Karachi, Pakistan
,
Zeeshan Sheikh
2   Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Ontario, Canada
,
Fahim Vohra
3   Department of Prosthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia
› Author Affiliations
Further Information

Publication History

Publication Date:
23 September 2019 (online)

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ABSTRACT

Denture base resins are extensively used in dentistry for a variety of purposes. These materials can be classified as chemical, heat, light, and microwave polymerization materials depending upon the factor which starts the polymerization reaction. Their applications include use during denture base construction, relining existing dentures, and for fabrication of orthodontic removable appliances. There have been increased concerns regarding the safe clinical application of these materials as their biodegradation in the oral environment leads to harmful effects. Along with local side effects, the materials have certain occupational hazards, and numerous studies can be found in the literature mentioning those. The purpose of this article is to outline the cytotoxic consequences of denture base acrylic resins and clinical recommendations for their use.

Key words:

Denture base allergy - denture base resins - residual monomer
 

  • REFERENCES

  • 1 León BL, Del Bel CuryAA, Rodrigues GarciaRC. Loss of residual monomer from resilient lining materials processed by different methods. Rev Odontol Ciênc 2008; 23: 215-9
    Google Scholar
  • 2 Bayraktar G, Guvener B, Bural C, Uresin Y. Influence of polymerization method, curing process, and length of time of storage in water on the residual methyl methacrylate content in dental acrylic resins. J Biomed Mater Res B Appl Biomater 2006; 76: 340-5
    Google Scholar
  • 3 Urban VM, Machado AL, Vergani CE, Giampaolo ET, Pavarina AC, de Almeida FG. et al. Effect of water-bath post-polymerization on the mechanical properties, degree of conversion, and leaching of residual compounds of hard chairside reline resins. Dent Mater 2009; 25: 662-71
    CrossrefPubMedGoogle Scholar
  • 4 Nironen P. Some possible uses for acrylic resins in dentistry. Odontol Tidskr 1950; 58: 118-25
    PubMedGoogle Scholar
  • 5 Eichhold WA, Woelfel JB. Denture base acrylic resins: Friend or foe?. Compendium 1990; 11: 720-5
    PubMedGoogle Scholar
  • 6 Faltermeier A, Rosentritt M, Müssig D. Acrylic removable appliances: Comparative evaluation of different postpolymerization methods. Am J Orthod Dentofacial Orthop 2007; 131: 301.e16-22
    Google Scholar
  • 7 Luo Y, Wang W, Yang Z. Clinical evaluation of two temporary restoration materials: Composite and self-cured acrylic resin. Hua Xi Kou Qiang Yi Xue Za Zhi 2003; 21: 222-5
    PubMedGoogle Scholar
  • 8 Tanoue N, Matsuda Y, Yanagida H, Matsumura H, Sawase T. Factors affecting the bond strength of denture base and reline acrylic resins to base metal materials. J Appl Oral Sci 2013; 21: 320-6
    CrossrefPubMedGoogle Scholar
  • 9 Makzoumé JE. Morphologic comparison of two neutral zone impression techniques: A pilot study. J Prosthet Dent 2004; 92: 563-8
    CrossrefPubMedGoogle Scholar
  • 10 Devaki VN, Manonmani P, Balu K, Aravind RJ. Clinical management of highly resorbed mandibular ridge without fibrous tissue. J Pharm Bioallied Sci 2012; 4 (Suppl. 02) S149-52
    PubMedGoogle Scholar
  • 11 Crispin B. Acrylic resin copings: An adjunct to fixed restorative dentistry. J Prosthet Dent 1978; 39: 632-6
    CrossrefPubMedGoogle Scholar
  • 12 Giunta JL, Grauer I, Zablotsky N. Allergic contact stomatitis caused by acrylic resin. J Prosthet Dent 1979; 42: 188-90
    CrossrefPubMedGoogle Scholar
  • 13 Weaver RE, Goebel WM. Reactions to acrylic resin dental prostheses. J Prosthet Dent 1980; 43: 138-42
    CrossrefPubMedGoogle Scholar
  • 14 Ali A, Bates JF, Reynolds AJ, Walker DM. The burning mouth sensation related to the wearing of acrylic dentures: An investigation. Br Dent J 1986; 161: 444-7
    CrossrefPubMedGoogle Scholar
  • 15 Koutis D, Freeman S. Allergic contact stomatitis caused by acrylic monomer in a denture. Australas J Dermatol 2001; 42: 203-6
    CrossrefPubMedGoogle Scholar
  • 16 Gonçalves TS, Morganti MA, Campos LC, Rizzatto SM, Menezes LM. Allergy to auto-polymerized acrylic resin in an orthodontic patient. Am J Orthod Dentofacial Orthop 2006; 129: 431-5
    CrossrefPubMedGoogle Scholar
  • 17 Cibirka RM, Nelson SK, Lefebvre CA. Burning mouth syndrome: A review of etiologies. J Prosthet Dent 1997; 78: 93-7
    CrossrefPubMedGoogle Scholar
  • 18 Van Joost T, van Ulsen J, van Loon LA. Contact allergy to denture materials in the burning mouth syndrome. Contact Dermatitis 1988; 18: 97-9
    CrossrefPubMedGoogle Scholar
  • 19 Rai R, Dinakar D, Kurian SS, Bindoo YA. Investigation of contact allergy to dental materials by patch testing. Indian Dermatol Online J 2014; 5: 282-6
    CrossrefPubMedGoogle Scholar
  • 20 Gosavi SS, Gosavi SY, Alla RK. Local and systemic effects of unpolymerised monomers. Dent Res J (Isfahan) 2010; 7: 82-7
    PubMedGoogle Scholar
  • 21 Fernström AI, Oquist G. Location of the allergenic monomer in warm-polymerized acrylic dentures. Part II: Experiments aimed at establishing guidelines for production of acrylic dentures suited for patients allergic to acrylic monomer and complementary investigations. Swed Dent J 1980; 4: 253-60
    PubMedGoogle Scholar
  • 22 Gawkrodger DJ. Investigation of reactions to dental materials. Br J Dermatol 2005; 153: 479-85
    CrossrefPubMedGoogle Scholar
  • 23 Usmani N, Wilkinson SM. Allergic skin disease: Investigation of both immediate- and delayed-type hypersensitivity is essential. Clin Exp Allergy 2007; 37: 1541-6
    PubMedGoogle Scholar
  • 24 Chaves CA, Machado AL, Vergani CE, de Souza RF, Giampaolo ET. Cytotoxicity of denture base and hard chairside reline materials: A systematic review. J Prosthet Dent 2012; 107: 114-27
    CrossrefPubMedGoogle Scholar
  • 25 Iça RB, Öztürk F, Ates B, Malkoc MA, Kelestemur Ü. Level of residual monomer released from orthodontic acrylic materials. Angle Orthod 2014; 84: 862-7
    CrossrefPubMedGoogle Scholar
  • 26 Nik TH, Shahroudi AS, Eraghihzadeh Z, Aghajani F. Comparison of residual monomer loss from cold-cure orthodontic acrylic resins processed by different polymerization techniques. J Orthod 2014; 41: 30-7
    CrossrefPubMedGoogle Scholar
  • 27 Gautam R, Singh RD, Sharma VP, Siddhartha R, Chand P, Kumar R. Biocompatibility of polymethylmethacrylate resins used in dentistry. J Biomed Mater Res B Appl Biomater 2012; 100: 1444-50
    Google Scholar
  • 28 Kopperud HM, Kleven IS, Wellendorf H. Identification and quantification of leachable substances from polymer-based orthodontic base-plate materials. Eur J Orthod 2011; 33: 26-31
    CrossrefPubMedGoogle Scholar
  • 29 McCabe JF, Walls A. Applied Dental Materials. 9th ed.. Oxford, UK: Willey-Blackwell; 2013: p. 112-3
    Google Scholar
  • 30 Anderson JN. Applied Dental Materials. 5th ed.. Oxford: Blackwell Scientific Publications; 1976: p. 245-70
    Google Scholar
  • 31 Douglas WH, Bates JF. The determination of residual monomer in polymethyl-methacrylate denture base resins. J Mater Sci 1978; 13: 2600-4
    CrossrefGoogle Scholar
  • 32 Pfeiffer P, Rosenbauer EU. Residual methyl methacrylate monomer, water sorption, and water solubility of hypoallergenic denture base materials. J Prosthet Dent 2004; 92: 72-8
    CrossrefPubMedGoogle Scholar
  • 33 Baker S, Brooks SC, Walker DM. The release of residual monomeric methyl methacrylate from acrylic appliances in the human mouth: An assay for monomer in saliva. J Dent Res 1988; 67: 1295-9
    Google Scholar
  • 34 Kedjarune U, Charoenworaluk N, Koontongkaew S. Release of methyl methacrylate from heat-cured and autopolymerized resins: Cytotoxicity testing related to residual monomer. Aust Dent J 1999; 44: 25-30
    CrossrefPubMedGoogle Scholar
  • 35 Goldibi F, Asghari G. The level of residual monomer in acrylic denture base materials. Res J Biol Sci 2009; 4: 244-9
    Google Scholar
  • 36 Celebi N, Yuzugullu B, Canay S, Yucel U. Effect of polymerization methods on the residual monomer level of acrylic resin denture base polymers. Polym Adv Technol 2008; 19: 201-6
    CrossrefGoogle Scholar
  • 37 Bartoloni JA, Murchison DF, Wofford DT, Sarkar NK. Degree of conversion in denture base materials for varied polymerization techniques. J Oral Rehabil 2000; 27: 488-93
    CrossrefPubMedGoogle Scholar
  • 38 Ogle RE, Sorensen SE, Lewis EA. A new visible light-cured resin system applied to removable prosthodontics. J Prosthet Dent 1986; 56: 497-506
    CrossrefPubMedGoogle Scholar
  • 39 Singh RD, Gautam R, Siddhartha R, Singh BP, Chand P, Sharma VP. et al. High performance liquid chromatographic determination of residual monomer released from heat-cured acrylic resin. An in vivo study. J Prosthodont 2013; 22: 358-61
    CrossrefPubMedGoogle Scholar
  • 40 Bural C, Aktas E, Deniz G, Unlucerci Y, Bayraktar G. Effect of leaching residual methyl methacrylate concentrations on in vitro cytotoxicity of heat polymerized denture base acrylic resin processed with different polymerization cycles. J Appl Oral Sci 2011; 19: 306-12
    CrossrefPubMedGoogle Scholar
  • 41 Jorge JH, Giampaolo ET, Machado AL, Vergani CE. Cytotoxicity of denture base acrylic resins: A literature review. J Prosthet Dent 2003; 90: 190-3
    CrossrefPubMedGoogle Scholar
  • 42 Harrison A, Huggett R. Effect of the curing cycle on residual monomer levels of acrylic resin denture base polymers. J Dent 1992; 20: 370-4
    CrossrefPubMedGoogle Scholar
  • 43 Ata SO, Yavuzyilmaz H. In vitro comparison of the cytotoxicity of acetal resin, heat-polymerized resin, and auto-polymerized resin as denture base materials. J Biomed Mater Res B Appl Biomater 2009; 91: 905-9
    Google Scholar
  • 44 Sheridan PJ, Koka S, Ewoldsen NO, Lefebvre CA, Lavin MT. Cytotoxicity of denture base resins. Int J Prosthodont 1997; 10: 73-7
    PubMedGoogle Scholar
  • 45 Cimpan MR, Cressey LI, Skaug N, Halstensen A, Lie SA, Gjertsen BT. et al. Patterns of cell death induced by eluates from denture base acrylic resins in U-937 human monoblastoid cells. Eur J Oral Sci 2000; 108: 59-69
    CrossrefPubMedGoogle Scholar
  • 46 Azzarri MJ, Cortizo MS, Alessandrini JL. Effect of the curing conditions on the properties of an acrylic denture base resin microwave-polymerised. J Dent 2003; 31: 463-8
    CrossrefPubMedGoogle Scholar
  • 47 Blagojevic V, Murphy VM. Microwave polymerization of denture base materials. A comparative study. J Oral Rehabil 1999; 26: 804-8
    CrossrefPubMedGoogle Scholar
  • 48 Lung CY, Darvell BW. Minimization of the inevitable residual monomer in denture base acrylic. Dent Mater 2005; 21: 1119-28
    CrossrefPubMedGoogle Scholar
  • 49 Lung CY, Darvell BW. Methyl methacrylate monomer-polymer equilibrium in solid polymer. Dent Mater 2007; 23: 88-94
    CrossrefPubMedGoogle Scholar
  • 50 Bereznowski Z. Effect of methyl methacrylate on mitochondrial function and structure. Int J Biochem 1994; 26: 1119-27
    CrossrefPubMedGoogle Scholar
  • 51 Drozdz K, Wysokinski D, Krupa R, Wozniak K. Bisphenol A-glycidyl methacrylate induces a broad spectrum of DNA damage in human lymphocytes. Arch Toxicol 2011; 85: 1453-61
    CrossrefPubMedGoogle Scholar
  • 52 Walther UI, Walther SC, Liebl B, Reichl FX, Kehe K, Nilius M. et al. Cytotoxicity of ingredients of various dental materials and related compounds in L2- and A549 cells. J Biomed Mater Res 2002; 63: 643-9
    CrossrefPubMedGoogle Scholar
  • 53 Sokmen S, Oktemer M. Histopathological examinations of rat lungs that exposed to low concentration of methyl methacrylate monomer vapor. J Hacettepe Factors Dent 1988; 12: 1-4
    Google Scholar
  • 54 Lozewicz S, Davies RJ. Inflammatory cells in allergic rhinitis. Respir Med 1991; 85: 259-61
    CrossrefPubMedGoogle Scholar
  • 55 Aalto-Korte K, Alanko K, Kuuliala O, Jolanki R. Methacrylate and acrylate allergy in dental personnel. Contact Dermatitis 2007; 57: 324-30
    CrossrefPubMedGoogle Scholar
  • 56 Böhling HG, Borchard U, Drouin H. Monomeric methylmethacrylate (MMA) acts on the desheathed myelinated nerve and on the node of Ranvier. Arch Toxicol 1977; 38: 307-14
    CrossrefPubMedGoogle Scholar
  • 57 Lamey PJ, Lewis MA. Oral medicine in practice: Burning mouth syndrome. Br Dent J 1989; 167: 197-200
    CrossrefPubMedGoogle Scholar
  • 58 Crissey JT. Stomatitis, dermatitis, and denture materials. Arch Dermatol 1965; 92: 45-8
    CrossrefPubMedGoogle Scholar
  • 59 Bauer A, Wollina U. Denture-induced local and systemic reactions to acrylate. Allergy 1998; 53: 722-3
    CrossrefPubMedGoogle Scholar
  • 60 Van’t Hof W, Veerman EC, Nieuw AmerongenAV, Ligtenberg AJ. Antimicrobial defense systems in saliva. Monogr Oral Sci 2014; 24: 40-51
    PubMedGoogle Scholar
  • 61 Tosti A, Piraccini BM, Peluso AM. Contact and irritant stomatitis. Semin Cutan Med Surg 1997; 16: 314-9
    CrossrefPubMedGoogle Scholar
  • 62 Kanerva L. Cross-reactions of multifunctional methacrylates and acrylates. Acta Odontol Scand 2001; 59: 320-9
    CrossrefPubMedGoogle Scholar
  • 63 Nakamura M, Oshima H, Hashimoto Y. Monomer permeability of disposable dental gloves. J Prosthet Dent 2003; 90: 81-5
    CrossrefPubMedGoogle Scholar
  • 64 Tansy MF, Martin JS, Benhaim S, Landin WE, Kendall FM. GI motor inhibition associated with acute exposure to methyl methacrylate vapor. J Pharm Sci 1977; 66: 613-9
    CrossrefPubMedGoogle Scholar
  • 65 Anderson SE, Meade BJ. Potential health effects associated with dermal exposure to occupational chemicals. Environ Health Insights 2014; 8 (Suppl. 01) 51-62
    PubMedGoogle Scholar