Drug-Device Combinations: Are They Appropriate for the Aging Population?

Hundreds of marketed products combine drugs with delivery devices. Experts estimate that these drug-device combinations (DDCs) generated nearly $24 billion in sales in 2014. DDCs appeal to clinicians and consumers for several reasons. Drugs delivered with a technology-assist may cause fewer side effects, avoid systemic exposure, result in a higher degree of efficacy, or create consistent blood levels. When physicians prescribe a DDC, consultant pharmacists have a unique role: ensuring patients can use the DDC appropriately. Available DDCs require some degree of eye-hand coordination, and older individuals often have difficulty with vision, dexterity, and grip strength. This review primarily discusses three types of DDC: those designed for diabetics, inhalers, and transdermal DDCs, and the characteristics that can challenge older patients.