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Neoplasma Ahead of print Neoplasma Vol.59, No.1, p.6-17, 2012
Neoplasma Ahead of print Neoplasma Vol.59, No.1, p.6-17, 2012
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Neoplasma Vol.59, No.1, p.6-17, 2012 |
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| Title: Differentiation pathways in carcinogenesis and in chemo- and radioresistance | ||
| Author: M. Janikova, J. Skarda | ||
| Abstract: Cancer stem cells (CSCs) share many features with embryonic stem cells (ESCs) such as the ability for self-renewal and differentiation. Signaling pathways that are involved in these processes are also involved in chemo- and radioresistance (e.g. Wnt, Notch and Hedgehog pathways). This review is focused on the influence of three important differentiation pathways on carcinogenesis and on chemo- and radioresistance in ESCs and CSCs. |
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| Keywords: Stem cell, Chemoresistance, Radioresistance, Wnt pathway, Notch pathway, Hedgehog pathway | ||
| Received: 18-Mar-2011 | Published online: 20-Oct-2011 | |
| Year: 2012, Volume: 59, Issue: 1 | Page From: 6, Page To: 17 | |
| doi:10.4149/neo_2012_002 |
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