Acta Univ. Palacki. Olomuc., Fac. Med. Volume 143, 2000 | DOI: 10.5507/bp.2000.002
INTERLEUKIN-1 FAMILY: FROM GENES TO HUMAN DISEASE
- Department of Immunology, Medical Faculty of Palacký University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic
Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiologicalimmune responses and in the development of various immunopathological disorders. The members of IL-1 familyform a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre ofresearch interests. This review article except of summarising recent findings about IL-1 family members focuses onassociations of IL-1 gene complex polymorphisms with human diseases.
Keywords: Interleukin-1, Interleukin-1 receptor antagonist, Gene polymorphism
Published: July 1, 2000 Show citation
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