Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(1):100-105 | DOI: 10.5507/bp.2015.048

Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

Katerina Juzlovaa,b, Jana Votrubovaa,b, Martina Dzambovaa,b, Dana Gopfertovab, Jana Hercogovaa, Zdeněk Smerhovskyb
a Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic
b Department of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic

Aims: The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis.

Methods: This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases.

Results: There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis.

Conclusion: Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.

Keywords: psoriasis, coeliac disease, inflammatory bowel diseases

Received: April 24, 2015; Accepted: September 11, 2015; Prepublished online: October 21, 2015; Published: March 30, 2016  Show citation

ACS AIP APA ASA Harvard Chicago IEEE ISO690 MLA NLM Turabian Vancouver
Juzlova, K., Votrubova, J., Dzambova, M., Gopfertova, D., Hercogova, J., & Smerhovsky, Z. (2016). Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls. Biomedical papers, 160(1), 100-105. doi: 10.5507/bp.2015.048
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Akbulut S, Gür G, Topal F, Senel E, Topal FE, Alli N, Saritas U. Coeliac disease-associated antibodies in psoriasis. Ann Dermatol 2013;25(3):298-303. Go to original source... Go to PubMed...
    2. Birkenfeld S, Dreiher J, Weitzman D, Cohen AD. Coeliac disease associated with psoriasis. Br J Dermatol 2009;161:1331-4. Go to original source... Go to PubMed...
    3. Bhatia BK, Millsop JW, Debbaneh M, Koo J, Linos E, Liao W. Diet and psoriasis, part II: celiac disease and role of a gluten-free diet. J Am Acad Dermatol 2014;71(2):350-8. Go to original source... Go to PubMed...
    4. De Bastiani R, Gabrielli M, Lora L, Napoli L, Tosetti C, Pirrotta E, Ubaldi E, Bertolusso L, Zamparella M, De Polo M, Nebiacolombo C, Bortot M, Mancuso M,Bacchin P, Marsala V, Pinna R, Tursi A, Benedetto E, Cuffari A, Pati A, Di Caro S, Perenzin G, Sala R, Calzavara Pinton G, Gasbarrini A. Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study. Dermatology 2015;230(2):156-60. Go to original source... Go to PubMed...
    5. Saurabh Aggarwal, Benjamin Lebwohl, Peter H. R. Green. Screening for celiac disease in average-risk and high-risk populations. Therap Adv Gastroenterol  201;5(1):37-47. Go to PubMed...
    6. Porcelli B, Ferretti F, Vindigni C, Terzuoli L. Assessment of a Test for the Screening and Diagnosis of Celiac Disease. J Clin Lab Anal 2014. doi: 10.1002/jcla.21816 Go to original source... Go to PubMed...
    7. Brusca I. Overview of biomarkers for diagnosis and monitoring of celiac disease. Adv Clin Chem 2015;68:1-55. doi: 10.1016/bs.acc.2014.12.006 Go to original source... Go to PubMed...
    8. Aust DE, Bläker H. Histological diagnosis and complications of celiac disease : Update according to the new S2k guidelines. Pathologe 2015;36(2):197-207. doi: 10.1007/s00292-015-0006-2 German. Go to original source... Go to PubMed...
    9. Shor DB, Orbach H, Boaz M, Altman A, Anaya JM, Bizzaro N, Tincani A, Cervera R, Espinosa G, Stojanovich L, Rozman B, Bombardieri S, Vita SD,Damoiseaux J, Villalta D, Tonutti E, Tozzoli R, Barzilai O, Ram M, Blank M, Agmon-Levin N, Shoenfeld Y. Gastrointestinal-associated autoantibodies in different autoimmune diseases. Am J Clin Exp Immunol 2012;1(1):49-55.
    10. Einarsdottir E, Koskinen LL, Dukes E, Kainu K, Suomela S, Lappalainen M, Ziberna F, Korponay-Szabo IR, Kurppa K, Kaukinen K, Adány R, Pocsai Z, Széles G, Färkkilä M, Turunen U, Halme L, Paavola-Sakki P, Not T, Vatta S, Ventura A, Löfberg R, Torkvist L, Bresso F, Halfvarson J, Mäki M, Kontula K, Saarialho-Kere U, Kere J, D'Amato M, Saavalainen P. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. BMC Med Genet 2009 28;10:8. Go to original source... Go to PubMed...
    11. Zhang XJ, Huang W, Yang S et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet  2009;41:205-10. Go to original source... Go to PubMed...
    12. Van Limbergen J, Wilson DC, Satsangi J. The genetics of Crohn's disease. Annu Rev Genomics Hum Genet 2009;10:89-116. Go to original source... Go to PubMed...
    13. Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato F. Th17 and non-classic Th1 cells in chronic inflammatory disorders: two sides of the same coin. Int Arch Allergy Immunol 2014;164(3):171-7. Review doi: 10.1159/000363502 Go to original source... Go to PubMed...
    14. Cullen G, Kroshinsky D, Cheifetz AS, Korzenik JR. Psoriasis associated with anti-tumour necrosis factor therapy in inflammatory bowel disease: a new series and a review of 120 cases from the literature. Aliment Pharmacol Ther 2011;34(11-12):1318-27. Go to original source... Go to PubMed...
    15. Li WQ, Han JL, Chan AT, Qureshi AA. Psoriasis, psoriatic arthritis and increased risk of incident Crohn's disease in US women. Ann Rheum Dis 2013;72(7):1200-5. Go to original source... Go to PubMed...
    16. van Schaik FD, Oldenburg B, Hart AR, Siersema PD, Lindgren S, Grip O, Teucher B, Kaaks R, Bergmann MM, Boeing H, Carbonnel F, Jantchou P, Boutron-Ruault MC, Tjønneland A, Olsen A, Crowe FL, Peeters PH, van Oijen MG, Bueno-de-Mesquita HB. Serological markers predict inflammatory bowel disease years before the diagnosis. Gut 2013;62(5):683-8. Go to original source... Go to PubMed...
    17. Nagui N, El Nabarawy E, Mahgoub D, Mashaly HM, Saad NE, El-Deeb DF. Estimation of (IgA) anti-gliadin, anti-endomysium and tissue transglutaminase in the serum of patients with psoriasis. Clin Exp Dermatol 2011;36(3):302-4. Go to original source... Go to PubMed...
    18. Sultan SJ, Ahmad QM, Sultan ST. Antigliadin antibodies in psoriasis. Australas J Dermatol 2010;51(4):238-42. Go to original source... Go to PubMed...
    19. Khan JM, Rao SU, Rathore MU, Janjua W. Association between psoriasis and coeliac disease related antibodies. J Ayub Med Coll Abbottabad 2014;26(2):203-6. Go to PubMed...
    20. Michaëlsson G, Gerdén B, Hagforsen E, Nilsson B, Pihl- Lundin I, Kraaz W, et al. Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet. Br J Dermatol 2000;142:44-51. Go to original source... Go to PubMed...
    21. Damasiewicz-Bodzek A, Wielkoszyński T. Serologic markers of celiac disease in psoriatic patients. J Eur Acad Dermatol Venereol 2008;22(9):1055-61. Go to original source... Go to PubMed...
    22. Cekic C, Arabul M, Alper E, Pakoz ZB, Saritas E, Yuksel, Ünsal B. . Evaluation of the relationship between serum ghrelin, C-reactive protein and interleukin-6 levels, and disease activity in inflammatory bowel diseases. Hepatogastroenterology 2014;61(133):1196-200. Go to original source... Go to PubMed...
    23. Nisihara RM, de Carvalho WB, Utiyama SR, Amarante H, Baptista ML. Diagnostic role and clinical association of ASCA and ANCA in Brazilian patients with inflammatory bowel disease. Dig Dis Sci 2010;55(8):2309-15. doi: 10.1007/s10620-009-0998-7 Go to original source... Go to PubMed...
    24. Israeli E, Grotto I, Gilburd B, Balicer RD, Goldin E, Wiik A, Shoenfeld Y. Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease. Gut 2005;54(9):1232-6. Go to original source... Go to PubMed...

    Return to the content