A Review on Phytochemistry of Cuminum cyminum seeds and its Standards from Field to Market

doi:10.5530/pj.2011.25.1

Pharmacognosy Journal

Volume 3, Issue 25, September 2011, Pages 1-5

https://doi.org/10.5530/pj.2011.25.1 Get rights and content

Abstract

The small boat shaped seeds of Cumin (Cuminum cyminum) has been used for many medicinal and culinary purposes from the ancient time in the various countries. Cumin is a popular spice in the world from Latin America to Northern Africa and all over the Asia and also used as a flavoring agent in many products such as cheese, pickle, soup, bean dishes or liqueurs. Essential oils of the seeds are also used as a flavor or in aromatherapy. Many pharmacological effects have been reported from this spicy plant as, anti-diabetic, Immunologic, anti-epileptic, anti-tumor and antimicrobial activities. Cumin used in the medicinal preparations is supposed to be produced with high quality encompasses all the properties of the final product which makes it optimal suitable for use. Reproducible quality is a goal, which achieved by the process of standardization. The focus here is rather on harvesting and processing of the cultivated species, because the quality of plant material and processing technology lead to the high quality of the final product. The quality of Cumin seeds and its essential oil can only be assessed with analytical methods, which include physical, microscopic and chemical analyzing assays. In this paper, the phytochemistry, medicinal properties and the standards from the field cultivation, harvesting and storage until marketing are reviewed.

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Ethnopharmacological reports on herbs used in the management of tuberculosis
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Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the most difficult diseases to control. Despite of various available synthetic anti-TB drugs, the emergence of multidrug resistance presents a significant challenge for the successful treatment of TB. Herbal therapeutics are becoming popular over the synthetic medicines due to their easy availability, low cost, and safety aspects. This review aimed to highlight the outcome of various plants-based antitubercular remedies. Various phytoconstituents like alkaloids, saponins, flavonoids, phenolic, tannins, terpenoids, quinones, steroids, etc., have shown promising antitubercular activity. However, very few studies have reported the mechanisms by which the phytoconstituent exert their anti-TB action. Thus, more attention is needed to explore the mechanism of phytoconstituent as anti-TB drug. This review will be of high relevance to the research scholars and formulation scientists working in the area of herbal drug development for the safe and effective treatment of TB.
Green synthesis of anatase titanium dioxide nanoparticles using Cuminum cyminum seed extract; effect on Mung bean (Vigna radiata) seed germination
2021, Inorganic Chemistry Communications
Citation Excerpt :
a small tree belonging to the family Apiaceae has been widely used as a flavoring agent in Southeast Asian cuisines due to its highly aromatic and unique flavors and strong fragrances. Cuminum cyminum seed extract possesses some important bioactive compounds, and possesses excellent antioxidant, antibacterial, antiseptic, antifungal and anti-inflammatory activities [13,14]. Previously, Cuminum cyminum seed extract have been used for synthesis of metal oxide nanoparticles such as silver [15], iron [16], copper [17], and gold [18].
This exploratory study investigated the apparent effect of biosynthesized Titanium dioxide nanoparticles (TiO₂NPs) using seed extract of Cuminum cyminum on seed germination and germination indices of Mung bean (Vigna radiata) to promote sustainable and biocompatible nano-agriculture. Optimal results of various characterization techniques like UV, XRD, FTIR, SEM, and TEM determined the successful formation of TiO₂NP which were capped with different phytochemicals present in the Cuminum cyminum extract. The observance of the peak at 419 cm⁻¹ confirms the synthesis of TiO₂NP. Anatase phase TiO₂NP with an average crystalline size of 15.17 nm was obtained using XRD and the existence of the element titanium (Ti) was revealed by critical EDS analysis. The nanoparticle was found to have good antioxidant potential. Moreover, this experiment was designed to observe the effect of biogenic TiO₂NPs on seed germination of the mung beans and to analyze plant growth parameters such as root length, shoot length, germination percentage, germination rate, and mean daily germination. Six possible concentrations (25, 50 100, 150, 200, and 250 µg mL⁻¹) of TiO₂NPs were examined along with the ultimate control. The TiO₂NPs penetrate mung bean seeds affecting grain germination and growth rate mechanism. Significant enhancement in germination indices values for Vigna radiata was observed by effective treatment with TiO₂NPs in comparison with non-treated seeds.
Preparation and Biological Activities of Novel Cuminaldehyde Derivatives
2021, Organic Preparations and Procedures International
Cuminum cyminum fruits as source of luteolin- 7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines
2020, Natural Product Research
Cuminum cyminum is famous for its spicy fruits used for culinary and therapeutic properties worldwide. Brine shrimp test was performed for detecting cytotoxic fractions and subfractions. Ethyl acetate (EA) and hexane (HE) fractions demonstrated LC₅₀ of 52.40 and 60.77 µg/ml against Artemia salina while other fractions showed no toxicity (LC₅₀> 500 µg/ml). Bioguided elucidation of EA and HE fractions were carried out and cytotoxicity of pure compounds were investigated against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal cell line (NIH/3T3) by MTT assay. Four flavone structures as luteolin, apigenin, luteolin-7-O-glucoside and apigenin-7-O-glucoside from EA and cuminoid A from HE were purified and identified. Luteolin-7-O-glucoside demonstrated potent anticancer activities against MCF-7 cell line (IC₅₀ of 3.98 µg/ml) with selectivity index of 8.0. In conclusion, flavonoids especially luteolin-7-O-glucoside play a significant role in cytotoxic effect of C. cyminum fruits and can be introduced as candidate for chemopreventive and chemotherapeutic drugs.
Improvement of cumin (Cuminum cyminum) seed performance under drought stress by seed coating and biopriming
2019, Scientia Horticulturae
Citation Excerpt :
This plant is cultivated extensively in regions with arid and semi-arid climates (Amini Dehaghi and MollFilabi, 2011). One problem with the production of cumin is its weak vigor since the seeds of this plant contain 10% oil (Gohari and Saeidnia, 2011) which is followed by increased sensitivity to environmental stresses. The seeds of cumin have wide variability in size and shape.
Cumin (Cuminum cyminum L.) is an annual plant with medicinal properties including numerous stimulus appetites; strengthen the stomach, anti-flatulence, which has low germination, vigor, storage substances, and weak establishment in the soil. In order to improve the physical and physiological properties and investigate the effect of seed coating and biopriming on morphological and biochemical indices of cumin seeds under drought stress a factorial experiment was conducted based on completely randomized design with three replications in the greenhouse at the Department of Agronomy and Plant Breeding, Yasouj University, Iran, in 2017. The experimental factors consisted of six combined levels of seed inoculation (inoculation with strain P.F2, and CHA0 Pseudomonas fluorescence bacteria, T36, T39 Trichoderma harzianum fungi, and without inoculation) with coating, and non-coating without inoculation as a control, and drought stress at three levels (0, -3 and -6 bar). Seed coating performs by 3:1.5:2 ratios of Vermiculite (V), Kaolin (K) and Perlite (P) than seed weight (5 g). Increasing drought stress leads to decreasing of seedling emergence and early vegetative growth of cumin under greenhouse conditions. The results indicated that the highest emergence percentage and rate was obtained from inoculation of coated seed with CHA0 at all osmotic potential conditions. Also, inoculation of coated seed with fungi or bacteria increased the soluble protein and antioxidant enzyme activity of seed. In general, biopriming the coated seed by T36 fungi or CHA0 bacteria improved the cumin seed performance and moderate somewhat the drawback of osmotic stress effects on seed germination and seedling establishment.
Cumin
2019, Medicinal Plants of South Asia: Novel Sources for Drug Discovery
Cumin (Cuminum cyminum L.) is a small annual herbaceous plant that is a member of the aromatic plant family (Apiaceae), also known as the Umbelliferae family. This plant was named the “best of condiments” in ancient Greece and well known due to its significant uses and has vast pharmaceutical significance. Cumin is an essential spice, and the seeds of this plant are well used to add flavor to spicy dishes in almost all the culinary preparations. The seeds of this plant and essential oil extracted from them are used in the food, perfumery, beverage, and drug sectors of industries. Due to its essential oil components, cumin has a strong warm aroma and unique flavor. Its main constituent aroma compounds are cumin aldehyde and cumin alcohol. The extent of each of these chemical constituents varies depending on the type of species. Furthermore, cumin seeds contain several phytochemicals that have several industrial applications that range from food to traditional value to pharmaceutical products. More efficient and tremendous uses of cumin are continuously added.

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Pharmacognosy Journal

Abstract

References (32)

Effect of sub-inhibitory concentrations of cumin (Cuminum cyminum L.) seed essential oil and alcoholic extract on the morphology, capsule expression and urease activity of Klebsiella pneumoniae

Int J Antimicrob Agents.

Effects of the fruit essential oil of Cuminum cyminum Linn. (Apiaceae) on pentylene tetrazolinduced epileptiform activity in F1 neurones of Helix aspersa

J Ethnopharmacol.

Effects of the fruit essential oil of Cuminum cyminum Linn. (Apiaceae) on acquisition and expression of morphine tolerance and dependence in mice

NeurosciLett.

Effects of the fruit essential oil of Cuminum cyminum L. on the acquisition and expression of morphine-induced conditioned place preference in mice

NeurosciLett.

Sesquiterpene lactone glucosides and alkyl glycosides from the fruit of cumin

Phytochemistry.

Glycosides of 2-C-methyl-D-erythritol from the fruits of anise, coriander and cumin

Phytochemistry.

Flora Iranica, Apiaceae

The Wealth of India: A Dictionary of Indian Raw Material and industrial Products

Cuminum cyminum and Carum carvi: An update

Phcog Rev.

Effect of cumin (Cuminum cyminum L.) seed essential oil on biofilm formation and plasmid integrity by Klebsiella pneumoniae

Pharmacog Mag.

Antimicrobial agents from plants: Antibacterial activity of plant volatile oils

J Appl Microbiol.

Chemistry, antioxidant, antibacterial and antifungal activities of volatile oils and their components

Nat Prod Commu.

Cited by (37)

Ethnopharmacological reports on herbs used in the management of tuberculosis

Green synthesis of anatase titanium dioxide nanoparticles using Cuminum cyminum seed extract; effect on Mung bean (Vigna radiata) seed germination

Preparation and Biological Activities of Novel Cuminaldehyde Derivatives

Cuminum cyminum fruits as source of luteolin- 7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines

Improvement of cumin (Cuminum cyminum) seed performance under drought stress by seed coating and biopriming

Cumin