Effect of Uric Acid on Coronary Microvascular Endothelial Function in Women: Association with eGFR and ADMA

So Kuwahata; Shuichi Hamasaki; Sanemasa Ishida; Tetsuro Kataoka; Akiko Yoshikawa; Koji Orihara; Masakazu Ogawa; Naoya Oketani; Keishi Saihara; Hideki Okui; Takuro Shinsato; Takuro Kubozono; Hitoshi Ichiki; Shoji Fujita; Takuro Takumi; Satoshi Yoshino; Mitsuhiro Nakazaki; Masaaki Miyata; Chuwa Tei

doi:10.5551/jat.1594

Original Article

Effect of Uric Acid on Coronary Microvascular Endothelial Function in Women: Association with eGFR and ADMA

So Kuwahata, Shuichi Hamasaki, Sanemasa Ishida, Tetsuro Kataoka, Akiko Yoshikawa, Koji Orihara, Masakazu Ogawa, Naoya Oketani, Keishi Saihara, Hideki Okui, Takuro Shinsato, Takuro Kubozono, Hitoshi Ichiki, Shoji Fujita, Takuro Takumi, Satoshi Yoshino, Mitsuhiro Nakazaki, Masaaki Miyata, Chuwa Tei

Author information

So Kuwahata
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Shuichi Hamasaki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Sanemasa Ishida
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Tetsuro Kataoka
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Akiko Yoshikawa
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Koji Orihara
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Masakazu Ogawa
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Naoya Oketani
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Keishi Saihara
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Hideki Okui
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Takuro Shinsato
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Takuro Kubozono
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Hitoshi Ichiki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Shoji Fujita
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Takuro Takumi
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Satoshi Yoshino
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Mitsuhiro Nakazaki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Masaaki Miyata
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Chuwa Tei
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.

Keywords: Uric acid, Endothelial function, Estimated glomerular filtration rate (eGFR), Asymmetric dimethylarginine (ADMA)

JOURNAL OPEN ACCESS

2010 Volume 17 Issue 3 Pages 259-269

DOI https://doi.org/10.5551/jat.1594

View "Advance Publication" version (March 13, 2010).

Details

Abstract

Aim: The aim of this study was to investigate the role of uric acid (UA) in coronary endothelial function via its effects on renal function, other coronary risk factors and asymmetric dimethylarginine (ADMA) in men and women.
Methods: The study population consisted of 194 consecutive patients (119 men and 75 women) without coronary artery disease. The relationships between UA and coronary endothelial function, estimated glomerular filtration rate (eGFR), ADMA or other biochemical or anthropometric parameters were investigated.
Results: Monovariate analysis of female participants demonstrated that % change in coronary blood flow (CBF) induced by acetylcholine (ACh) was inversely correlated with UA, ADMA and age (r=-0.32, p<0.01; r=-0.31, p<0.05; r=-0.23, p<0.05, respectively), and positively correlated with eGFR (r=0.27, p<0.05). Stepwise regression analysis showed that UA was the only independent predictor of % change in CBF induced by ACh (F value 4.969, p<0.05). Similar analysis of male participants failed to show significant correlations of these variables except for age in monovariate analysis (r=-0.19, p<0.05). Meanwhile, UA was inversely correlated with eGFR in both men and in women (r=-0.25, p<0.01; r=-0.59, p<0.0001, respectively), and ADMA was positively correlated with UA and inversely correlated with eGFR (r=0.36, p<0.05; r=-0.42, p<0.01, respectively) in women but not in men.
Conclusion: High concentrations of UA correlate with coronary endothelial microvascular dysfunction in women. Further, serum UA concentration is related to eGFR and ADMA only in women, which may result in impaired endothelial function in resistance coronary arteries in women but not in men.

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