In vitro interaction of eupomatenoid-5 from Piper solmsianum C. DC. var. solmsianum and anti-tuberculosis drugs
OBJECTIVE: To evaluate the in vitro interaction between eupomatenoid-5 (EUP-5), extracted from Piper solmsianum C. DC. var. solmsianum, and first-line anti-tuberculosis drugs against Mycobacterium tuberculosis H37Rv and 20 clinical isolates.
DESIGN: Resazurin drugs combination microtiter assay (REDCA) was performed to determine the interaction between EUP-5 and isoniazid, rifampicin (RMP) and ethambutol (EMB).
RESULTS: Synergism was observed in M. tuberculosis H37Rv and eight clinical isolates with EUP-5+RMP, and in M. tuberculosis H37Rv and 17 clinical isolates with EUP-5+EMB combinations.
CONCLUSION: EUP-5 is a promising compound for further studies on the development of anti-tuberculosis drugs.
Keywords: Mycobacterium tuberculosis; checkerboard method; synergism
Document Type: Research Article
Affiliations: 1: Postgraduate Programme in Biosciences Applied to Pharmacy 2: Laboratory of Medical Bacteriology, Department of Clinical Analysis and Biomedicine 3: Laboratory of Pharmacognosy, Department of Pharmacy, State University of Maringá, Maringá, Paraná 4: Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil 5: Postgraduate Programme in Biosciences Applied to Pharmacy, Laboratory of Medical Bacteriology, Department of Clinical Analysis and Biomedicine
Publication date: 01 December 2014
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