Bacterial aetiology and mortality in COPD patients with CAP: results from the German Competence Network, CAPNETZ
OBJECTIVES: 1) To assess the bacterial aetiology of CAP only and CAP-COPD, and 2) to study the association between bacterial aetiology, empirical antibiotic treatment, serum markers and mortality.
METHODS: Of 1288 patients with CAP (57.0% males, age 59.0 years ± 18.5), 262 (20.3%) fulfilled the diagnostic criteria for COPD. Differences between subgroups were investigated using univariate analyses and corrected for multiple comparisons.
RESULTS: Streptococcus pneumoniae was the most common pathogen (30.8% CAP only vs. 26.0% CAP-COPD, not significant). Haemophilus influenzae was significantly more frequent in CAP-COPD (5.6% CAP only vs. 26.0% CAP-COPD, P < 0.001). The number given adequate empirical antibiotic treatment was comparable (83.3% CAP only vs. 83.6% CAP-COPD, P > 0.05). The CAP-COPD group had worse CURB-65 and partial pressure of arterial oxygen levels than the CAP only group (P < 0.001). Partial pressure of arterial carbon dioxide levels were increased in CAP-COPD patients without pathogen detection (P < 0.001). Short- (P = 0.011) and long-term mortality (P = 0.006) were highest in CAP-COPD without pathogen detection.
CONCLUSION: It is important to identify COPD patients with CAP. In particular, those without bacterial pathogen detection have more severe CAP and are at higher risk of dying. Better understanding of the aetiology could contribute to improved management and treatment of CAP in COPD patients.
Keywords: chronic lung disease; microbiology; pathogen detection; respiratory infections; survival
Document Type: Research Article
Affiliations: 1: Department of Research and Education, CIRO, Horn, Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands 2: Department of Medical Microbiology and Hygiene, University Hospital of Ulm, Ulm 3: Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, Ernst von Bergmann Klinikum, Potsdam, CAPNETZ Stiftung, Hannover, Germany 4: CAPNETZ Stiftung, Hannover, Center for Diseases and Infection Control, Jena University Hospital, Jena 5: CAPNETZ Stiftung, Hannover, Department of Molecular and Clinical Infectious Diseases, University of Lübeck, Lübeck, Germany 6: Department of Medical Microbiology, MUMC+, Maastricht, The Netherlands 7: Department of Research and Education, CIRO, Horn, CAPNETZ Stiftung, Hannover, Germany
Publication date: 01 February 2017
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