doi: 10.5732/cjc.010.10588

Clinical microdialysis in neuro-oncology: principles and applications

J. Clay Goodman

Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA. jgoodman@bcm.edu.

[Abstract] Clinical microdialysis allows a discrete volume of the brain to be sampled for neurochemical analysis of neurotransmitters, metabolites, biomarkers, and drugs. The technique can be safely used in humans intraoperatively, in the intensive care unit, and in ambulatory settings. Microdialysis probes, micropumps, and analytical equipment are commercially available and have been used extensively for neurochemical monitoring in traumatic brain injury, stroke, and subarachnoid hemorrhage. There has been very limited use of microdialysis in neuro-oncology, but this technique has great promise in the study of the basic neurochemistry of brain tumors, alterations in neurochemistry in response to therapy, and the pharmacokinetics of chemotherapeutic agents. Microdialysis probes may also be used to deliver drugs while simultaneously permitting monitoring of neurochemical changes induced by this therapy.

Chinese Journal of Cancer 2011, Volume: 30, Issue 3, Page: 173-181

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J. Clay Goodman. Clinical microdialysis in neuro-oncology: principles and applications. Chin J Cancer. 2011, 30(3):173-181. doi:10.5732/cjc.010.10588


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