Incidence of Acute Exacerbation of Interstitial Pneumonia in Operated Lung Cancer: Institutional Report and Review

Masayuki Chida; Satoru Kobayashi; Yoko Karube; Makio Hayama; Motohiko Tamura; Hiromi Ishihama; Takeshi Oyaizu

doi:10.5761/atcs.oa.11.01839

Original Articles

Incidence of Acute Exacerbation of Interstitial Pneumonia in Operated Lung Cancer: Institutional Report and Review

Masayuki Chida, Satoru Kobayashi, Yoko Karube, Makio Hayama, Motohiko Tamura, Hiromi Ishihama, Takeshi Oyaizu

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Keywords: interstitial pneumonia, idiopathic pulmonary fibrosis, acute exacerbation, lung cancer, complication

JOURNAL FREE ACCESS

2012 Volume 18 Issue 4 Pages 314-317

DOI https://doi.org/10.5761/atcs.oa.11.01839

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Abstract

Purpose: Several small studies have reported that acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection for patients with non-small cell lung cancer, though the incidence rate is unclear.
Methods: We examined our institutional data and performed a search of the MEDLINE database for publications regarding AE of IIP following surgery for lung cancer. Studies reporting the incidence rates of IIP and AE were included.
Results: Eleven studies including our institutional data were determined to be eligible. Seven studies designated the incidence of IIP. Of 4749 patients (from 7 studies) who underwent lung resection for NSCLC, 277 had IIP, for an incidence rate of 5.8% (range 1.1%–11.7%). Eleven studies designated the incidence of AE from IIP patient, 67 (15.8%) of 424 IIP patients (from 11 studies) developed AE after surgery, of whom 38 (56.7%) died during the postoperative course.
Conclusion: Coexistent IIP in patients with lung cancer increases the risk of lung cancer surgery. Furthermore, AE of IIP may be a major cause of operation-related death.

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