Background and Objectives: Certain patients who undergo proximal jejunum resection are unable to undergoprimary anastomosis and require exteriorization of the proximal jejunum. These patients usually have major problemswith short bowel due to the high output of the stoma. The output of a proximal jejunostomy contains abundantamounts of enzymes and electrolytes. Therefore, it is a feasible approach to re-infuse jejunostomy output toregain homeostasis. To evaluate the effects of proximal jejunostomy output reinfusion into the distal small bowelfor patients with short bowel syndrome, and to determine whether reinfusion could avoid long-term parenteral nutrition(PN). Methods and Study Design: PN was initiated immediately after surgery. When patients started enteralnutrition, we started the proximal jejunostomy output reinfusion protocol. Proximal jejunostomy output reinfusionwas performed by the patients, and continued by them after discharge. When proximal jejunostomy outputreinfusion could be performed stably, PN was stopped. Results: The median length of the proximal jejunum was20 cm and of the distal small bowel was 77.5 cm in patients who could stably receive proximal jejunostomy outputreinfusion alone. Three patients did not require home PN; they only required PN during hospitalization. Fourpatients successfully underwent stoma takedown with intestinal anastomosis after 6-7 months without any nutritionalor metabolic complications. Conclusion: Short bowel syndrome patients with an adequate length of smallbowel and functional colon could avoid long-term PN by receiving reinfusion of proximal jejunostomy output intothe distal small bowel.