IONOMYCIN, A NEW POLYETHER ANTIBIOTIC

WEN-CHIN LIU; DOROTHY SMITH SLUSARCHYK; GAIL ASTLE; WILLIAM H. TREJO; WILLIAM E. BROWN; EDWARD MEYERS

doi:10.7164/antibiotics.31.815

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

IONOMYCIN, A NEW POLYETHER ANTIBIOTIC

WEN-CHIN LIU, DOROTHY SMITH SLUSARCHYK, GAIL ASTLE, WILLIAM H. TREJO, WILLIAM E. BROWN, EDWARD MEYERS

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1978 Volume 31 Issue 9 Pages 815-819

DOI https://doi.org/10.7164/antibiotics.31.815

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Abstract

Ionomycin, a new polyether antibiotic with a high affinity for calcium ions, is obtained in pure form from fermentation broths of Streptomyces conglobatus sp. nov. TREJO by solvent extraction. It is unique amongst known polyether antibiotics in that it has a UV absorption maximum at 300 nm, thereby distinguishing it from other antibiotics of its class. The Ca salt has the molecular formula C₄₁H₇₀O₉Ca. Ionomycin is a narrow spectrum antibiotic being active against Gram-positive bacteria.

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