STUDIES ON WF-3161, A NEW ANTITUMOR ANTIBIOTIC

KAZUYOSHI UMEHARA; KUNIO NAKAHARA; SUMIO KIYOTO; MORITA IWAMI; MASANORI OKAMOTO; HIROKAZU TANAKA; MASANOBU KOHSAKA; HATSUO AOKI; HIROSHI IMANAKA

doi:10.7164/antibiotics.36.478

KAZUYOSHI UMEHARA, KUNIO NAKAHARA, SUMIO KIYOTO, MORITA IWAMI, MASANORI OKAMOTO, HIROKAZU TANAKA, MASANOBU KOHSAKA, HATSUO AOKI, HIROSHI IMANAKA

Author information

KAZUYOSHI UMEHARA
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KUNIO NAKAHARA
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SUMIO KIYOTO
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MORITA IWAMI
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASANORI OKAMOTO
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HIROKAZU TANAKA
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASANOBU KOHSAKA
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HATSUO AOKI
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HIROSHI IMANAKA
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1983 Volume 36 Issue 5 Pages 478-483

DOI https://doi.org/10.7164/antibiotics.36.478

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Abstract

WF-3161 is an antitumor antibiotic produced by a strain of fungus, Petriella guttulata. The antibiotic was purified by solvent extraction and a combination of silica gel and reverse phase column chromatography. The chemical structure of the antibiotic (C31H44N4O6, mp 181-183°C) was found to be a cyclic tetrapeptide consisting of phenylalanine, leucine, pipecolinic acid and 2-amino-8-oxo-9, 10-epoxydecanoic acid. WF-3161 inhibited the growth of Trichophyton asteroides. It prolonged survival period of mice bearing leukemia P-388 with a high therapeutic index.

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