The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SOLATION AND STRUCTURAL ELUCIDATION OF NEW CYCLOTETRAPEPTIDES, TRAPOXINS A AND B, HAVING DETRANSFORMATION ACTIVITIES AS ANTITUMOR AGENTS
HIROSHI ITAZAKI, KAZUO NAGASHIMA, KENJI SUGITA, HIROSHI YOSHIDA, YOSHIMI KAWAMURA, YUKIO YASUDA, KOICHI MATSUMOTO, KIKUO ISHII, NOBUO UOTANI, HIROSHI NAKAI, AKIHIRO TERUI, SHINYA YOSHIMATSU, YUJI IKENISHI, YUZO NAKAGAWA
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1990 Volume 43 Issue 12 Pages 1524-1532

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Abstract

New cyclotetrapeptides, trapoxins A and B were isolated from the culture broth of Helicoma ambiens RF-1023. These compounds exhibit detransformation activities against v-sis oncogenetransformed NIH3T3 cells (sis/NIH3T3) as antitumor agents. The structures were found to be new cyclotetrapeptides, cyclo[(S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S, 9S)-2-amino-8-oxo-9, 10-epoxydecanoyl-] for trapoxin A and cyclo[(S)-phenylalanyl-(S)-phenylalanyl-(R)-prolyl-2-amino-8-oxo-9, 10-epoxydecanoyl-] for trapoxin B, by X-ray analysis, mass spectrometric, NMR and chemical studies.

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The Journal of Antibiotics, Series A

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