[关键词]
[摘要]
目的 研究明党参Changium smyrnioides根皮的化学成分。方法 采用硅胶柱色谱、反相柱色谱以及LH-20凝胶柱色谱等多种技术进行分离纯化，并根据理化性质及波谱数据进行结构鉴定。结果 从明党参根皮95%乙醇提取物中分离得到了15个化合物，分别鉴定为欧前胡素（1）、珊瑚菜内酯（2）、花椒毒酚（3）、5-羟基8-甲氧基补骨脂素（4）、香草酸（5）、别欧前胡素（6）、补骨脂素（7）、佛手柑内酯（8）、5-甲氧基-8-O-β-D-葡萄糖基补骨脂素（9）、异茴芹内酯（10）、咖啡酸（11）、橙黄胡椒酰胺乙酸酯（12）、vaginatin（13）、β-谷甾醇（14）、琥珀酸（15）。结论 化合物6～13为首次从党参属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the root bark of Changium smyrnioides. Methods Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, and recycling preparative HPLC from the ethanol extract in the root bark of C. smyrnioides, and their structures were elucidated by the physicochemical characteristics and spectral analyses. Results Fifteen chemical constituents were obtained and identified as imperatorin (1), phellopterin (2), xanthotoxol (3), 5-hydroxy-8-methoxy-psoralen (4), vanillic acid (5), alloimperatorin (6), psoralen (7), bergapten (8), 8-O-β-D-glucopyranosyl- 5-methoxylpsoralen (9), isopimpinellin (10), caffeic acid (11), aurantiamide acetate (12), vaginatin (13), β-sitosterol (14), and succinic acid (15). Conclusion Compounds 6—13 are isolated from the plants in Changium Wolff for the first time.
[中图分类号]
[基金项目]
江苏高校优势学科建设工程资助项目（ysxk-2010）；高等学校博士学科点专项科研基金（200803150009）；江苏省自然科学基金资助项目（BK2003107）
