Evaluation of Topoisomerase Ⅰ/ Topoisomerase Ⅱα Status in Esophageal Cancer

Takeshi HANAGIRI; Kenji ONO; Taiji KUWATA; Masaru TAKENAKA; Soichi OKA; Yasuhiro CHIKAISHI; Yoshiki SHIGEMATSU; Yoshika NAGATA; Hidehiko SHIMOKAWA; Makoto NAKAGAWA; Hidetaka URAMOTO; Tomoko So; Fumihiro TANAKA

doi:10.7888/juoeh.33.205

Takeshi HANAGIRI, Kenji ONO, Taiji KUWATA, Masaru TAKENAKA, Soichi OKA, Yasuhiro CHIKAISHI, Yoshiki SHIGEMATSU, Yoshika NAGATA, Hidehiko SHIMOKAWA, Makoto NAKAGAWA, Hidetaka URAMOTO, Tomoko So, Fumihiro TANAKA

Author information

Takeshi HANAGIRI
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Kenji ONO
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Taiji KUWATA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Masaru TAKENAKA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Soichi OKA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Yasuhiro CHIKAISHI
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Yoshiki SHIGEMATSU
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Yoshika NAGATA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Hidehiko SHIMOKAWA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Makoto NAKAGAWA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Hidetaka URAMOTO
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Tomoko So
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health
Fumihiro TANAKA
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health

Keywords: esophageal cancer, surgical resection, topoisomerase Ⅰ, topoisomerase Ⅱα, immunohistochemistry

JOURNAL FREE ACCESS

2011 Volume 33 Issue 3 Pages 205-216

DOI https://doi.org/10.7888/juoeh.33.205

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Abstract

Human DNA topoisomerases Ⅰ and Ⅱα (Topo-Ⅰ and -Ⅱα) are essential for vital cellular processes such as DNA replication, transcription, translation, recombination, and repair. The purpose of this study was to investigate the clinical significance of the expression of Topo-Ⅰ and Topo-Ⅱα. Twenty-nine specimens of esophageal squamous cell carcinoma from patients who had been treated by complete resection of the esophageal tumor were studied by an immunohistochemical analysis. High expression of Topo Ⅰ and Ⅱα was identified in 48.7% and 55.2% of tumors, respectively. Neither the Topo-Ⅰ nor -Ⅱα expression level had any association with clinical characteristics, including differentiation and the depth of tumor invasion, lymph node metastasis, or the patient prognosis. However, a significant positive correlation was observed between the expression levels of Topo-Ⅰ and Topo-Ⅱα. Our study results underscore the potential role of topoisomerase expression in esophageal cancer and further exploratory investigation is necessary to evaluate topoisomerase expression as a surrogate marker in chemotherapy with topoisomerase inhibitor for esophageal cancer.

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