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Current Osteoporosis Reports

Erschienen in:

07.02.2018 | Secondary Causes of Osteoporosis (S Warden, Section Editor)

Linking the Gut Microbiota to Bone Health in Anorexia Nervosa

verfasst von: Nicole C. Aurigemma, Kristen J. Koltun, Hannah VanEvery, Connie J. Rogers, Mary Jane De Souza

Erschienen in: Current Osteoporosis Reports | Ausgabe 1/2018

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Abstract

Purpose of Review

The purpose of this review is to examine the anorexia nervosa-microbiota-bone relationship, offering a compilation of the relevant human and animal studies that may contribute to a more comprehensive understanding of potential mechanisms involved.

Recent Findings

Recent studies have implicated fermentation by-products of the gut microbiota in bone metabolism.

Summary

Compromised bone health often accompanies anorexia nervosa due to energy deficiency and hypoestrogenism. The gut microbiome has been implicated as a link between these conditions and impaired bone growth phenotypes. Current research supports decrements in Firmicutes and short-chain fatty acids with increases in Methanobrevibacter smithii and Proteobacteria in anorexia nervosa. A potential mechanism for microbiome-regulated bone growth is through modulation of insulin-like growth factor-1. Future research should aim to examine short-chain fatty acids, probiotics, and prebiotics as alternative therapies to treat low bone density in anorexia nervosa.

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Titel: Linking the Gut Microbiota to Bone Health in Anorexia Nervosa
verfasst von: Nicole C. Aurigemma
Kristen J. Koltun
Hannah VanEvery
Connie J. Rogers
Mary Jane De Souza
Publikationsdatum: 07.02.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 1/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0420-5

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Linking the Gut Microbiota to Bone Health in Anorexia Nervosa

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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