Skip to main content
main-content

07.02.2018 | Secondary Causes of Osteoporosis (S Warden, Section Editor) | Ausgabe 1/2018

Current Osteoporosis Reports 1/2018

Linking the Gut Microbiota to Bone Health in Anorexia Nervosa

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 1/2018
Autoren:
Nicole C. Aurigemma, Kristen J. Koltun, Hannah VanEvery, Connie J. Rogers, Mary Jane De Souza
Wichtige Hinweise
This article is part of the Topical Collection on Secondary Causes of Osteoporosis

Abstract

Purpose of Review

The purpose of this review is to examine the anorexia nervosa-microbiota-bone relationship, offering a compilation of the relevant human and animal studies that may contribute to a more comprehensive understanding of potential mechanisms involved.

Recent Findings

Recent studies have implicated fermentation by-products of the gut microbiota in bone metabolism.

Summary

Compromised bone health often accompanies anorexia nervosa due to energy deficiency and hypoestrogenism. The gut microbiome has been implicated as a link between these conditions and impaired bone growth phenotypes. Current research supports decrements in Firmicutes and short-chain fatty acids with increases in Methanobrevibacter smithii and Proteobacteria in anorexia nervosa. A potential mechanism for microbiome-regulated bone growth is through modulation of insulin-like growth factor-1. Future research should aim to examine short-chain fatty acids, probiotics, and prebiotics as alternative therapies to treat low bone density in anorexia nervosa.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt e.Med bestellen und 100 € sparen!

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2018

Current Osteoporosis Reports 1/2018 Zur Ausgabe

Genetics (M Johnson and S Ralston, Section Editors)

Regulation of Bone Metabolism by microRNAs

Genetics (M Johnson and S Ralston, Section Editors)

Genetics of Osteopetrosis

Osteocytes (T Bellido and J Klein Nulend, Section Editors)

Solute Transport in the Bone Lacunar-Canalicular System (LCS)

Skeletal Development (P Trainor and K Svoboda, Section Editors)

Exosomes in Extracellular Matrix Bone Biology

Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)

Diabetes and Abdominal Aortic Calcification—a Systematic Review

Muscle and Bone (L Bonewald and M Hamrick, Section Editors)

The Role of Bone Secreted Factors in Burn-Induced Muscle Cachexia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise