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Erschienen in: Acta Diabetologica 6/2016

18.07.2016 | Original Article

Lipid and inflammatory biomarker profiles in early insulin resistance

verfasst von: Itahisa Marcelino Rodríguez, José Oliva García, José Juan Alemán Sánchez, Delia Almeida González, Santiago Domínguez Coello, Buenaventura Brito Díaz, Fadoua Gannar, María del Cristo Rodríguez Pérez , Roberto Elosua, Antonio Cabrera de León

Erschienen in: Acta Diabetologica | Ausgabe 6/2016

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Abstract

Aims

To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR).

Methods

Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL).

Results

E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07–4.89]), HDL cholesterol (OR 0.35 [0.28–0.44]), sCD40L (OR 0.47 [0.24–0.94]), C-reactive protein (OR 2.31 [1.29–4.12]), adiponectin (OR 0.11 [0.04–0.32]), PAI-1 (OR 3.29 [1.29–8.40]) and resistin (OR 1.25 [1.01–1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58–0.93]).

Conclusions

Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.
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Metadaten
Titel
Lipid and inflammatory biomarker profiles in early insulin resistance
verfasst von
Itahisa Marcelino Rodríguez
José Oliva García
José Juan Alemán Sánchez
Delia Almeida González
Santiago Domínguez Coello
Buenaventura Brito Díaz
Fadoua Gannar
María del Cristo Rodríguez Pérez
Roberto Elosua
Antonio Cabrera de León
Publikationsdatum
18.07.2016
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 6/2016
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-016-0885-6

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