Erschienen in:
18.07.2016 | Original Article
Lipid and inflammatory biomarker profiles in early insulin resistance
verfasst von:
Itahisa Marcelino Rodríguez, José Oliva García, José Juan Alemán Sánchez, Delia Almeida González, Santiago Domínguez Coello, Buenaventura Brito Díaz, Fadoua Gannar, María del Cristo Rodríguez Pérez
, Roberto Elosua, Antonio Cabrera de León
Erschienen in:
Acta Diabetologica
|
Ausgabe 6/2016
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Abstract
Aims
To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR).
Methods
Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL).
Results
E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07–4.89]), HDL cholesterol (OR 0.35 [0.28–0.44]), sCD40L (OR 0.47 [0.24–0.94]), C-reactive protein (OR 2.31 [1.29–4.12]), adiponectin (OR 0.11 [0.04–0.32]), PAI-1 (OR 3.29 [1.29–8.40]) and resistin (OR 1.25 [1.01–1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58–0.93]).
Conclusions
Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.