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International Journal of Diabetes in Developing Countries

Erschienen in:

18.03.2015 | Original Article

Lipid peroxidation, antioxidants, lipid profile, and HbA1c in diabetic patients

verfasst von: Chhunthang Thanpari, Roshan Takhelmayum, Naval Kishor Yadav, Mukesh Kumar Shrewastwa, Priyanka Thapa, Ravindra Kumar Mittal

Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 2/2017

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Abstract

Diabetes mellitus is characterized by hyperglycemia together with biochemical changes in glucose, lipid profile, lipid peroxidation, and antioxidants status. This study aims to assess lipid profile, lipid peroxidation, antioxidants, and glycated hemoglobin (HbA1c) in type 1 and type 2 diabetic subjects. Type 1 and type 2 diabetic patients were selected from the subjects attending OPD in Nepalgunj Medical College, Nepal, for medical checkup. Fasting blood sugar (FBS), lipid profile, lipid peroxidation (malondialdehyde), and antioxidants status (reduced glutathione and vitamin E) were estimated in both groups and were compared with healthy controls. Low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio was calculated to assess the cardiovascular risk factors. When type 1 diabetic patients were compared with type 2 diabetic patients, it showed statistically significant increase in the levels of HbA1c, triglycerides (TGs), and high-density lipoprotein cholesterol (HDL-C), whereas statistically significant decreased level was found in malondialdehyde (MDA). FBS, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), vitamin E, and HDL/LDL ratio were not significant. Early diagnosis of dyslipidemia and oxidative stress can be used as a preventive measure for the development of microvascular and macrovascular complications in type 1 and type 2 diabetes mellitus.

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Titel: Lipid peroxidation, antioxidants, lipid profile, and HbA1c in diabetic patients
verfasst von: Chhunthang Thanpari
Roshan Takhelmayum
Naval Kishor Yadav
Mukesh Kumar Shrewastwa
Priyanka Thapa
Ravindra Kumar Mittal
Publikationsdatum: 18.03.2015
Verlag: Springer India
Erschienen in: International Journal of Diabetes in Developing Countries / Ausgabe 2/2017
Print ISSN: 0973-3930
Elektronische ISSN: 1998-3832
DOI: https://doi.org/10.1007/s13410-015-0356-6

Springer Medizin

Abstract

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