Skip to main content
Erschienen in: Current Colorectal Cancer Reports 1/2022

23.03.2022 | Surgery and Surgical Innovations in Colorectal Cancer (M Al-Kasspooles, Section Editor)

Liver-Directed Therapy for Metastatic Colon Cancer: Update

verfasst von: John J. Waddell, Patricia H. Townsend, Zachary S. Collins, Carissa Walter

Erschienen in: Current Colorectal Cancer Reports | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

To discuss the emerging technologies in the field of Interventional radiology (IR) for the management of metastatic colorectal cancer (mCRC). We review the field of selective internal radiation therapy (SIRT), and well-known IR treatments, with a more focused investigation of radioembolization with Yttrium-90 (Y-90).

Recent Findings

State-of-the-art treatment modalities for unresectable hepatic malignancies are crucial to increased patient survival. There are many options for the treating physician to manage and potentially cure patient’s disease, with Y-90 as the cornerstone of liver neoplasm treatment. Additionally, current research in the fields of dosimetry and radiomics may allow for more optimized patient specific radiation doses.

Summary

Continued advancements in colorectal surgery and interventional radiology have improved survival outcomes for patients with mCRC. Current treatment options are numerous and often include partial hepatectomy and SIRT. We review current literature and discuss our experiences in treating patients with advanced liver malignancies.
Literatur
1.
Zurück zum Zitat Biller LH, Schrag D. Diagnosis and treatment of metastatic colorectal cancer: a review. JAMA. 2021;325(7):669–85.PubMedCrossRef Biller LH, Schrag D. Diagnosis and treatment of metastatic colorectal cancer: a review. JAMA. 2021;325(7):669–85.PubMedCrossRef
2.
Zurück zum Zitat Tan HL, Lee M, Vellayappan BA, Neo WT, Yong WP. The role of liver-directed therapy in metastatic colorectal cancer. Curr Colorectal Cancer Rep. 2018;14(5):129–37.PubMedPubMedCentralCrossRef Tan HL, Lee M, Vellayappan BA, Neo WT, Yong WP. The role of liver-directed therapy in metastatic colorectal cancer. Curr Colorectal Cancer Rep. 2018;14(5):129–37.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Li J, Wei X, Liu Y, Cui B. Prognostic significance of distant metastasis location in patients with metastatic colorectal cancers. Int J Clin Exp Med. 2016;9(11):21681–9. Li J, Wei X, Liu Y, Cui B. Prognostic significance of distant metastasis location in patients with metastatic colorectal cancers. Int J Clin Exp Med. 2016;9(11):21681–9.
5.
Zurück zum Zitat Gabriela Chiorean E, Nandakumar G, Fadelu T, Temin S, Alarcon-Rozas AE, Bejarano S, et al. Treatment of patients with late-stage colorectal cancer: ASCO resource-stratified guideline. J Global Oncol. 2020;6:414–38.CrossRef Gabriela Chiorean E, Nandakumar G, Fadelu T, Temin S, Alarcon-Rozas AE, Bejarano S, et al. Treatment of patients with late-stage colorectal cancer: ASCO resource-stratified guideline. J Global Oncol. 2020;6:414–38.CrossRef
6.
Zurück zum Zitat Swaid F, Tsung A. Current management of liver metastasis from colorectal cancer. Curr Colorectal Cancer Rep. 2018;14(1):12–21.CrossRef Swaid F, Tsung A. Current management of liver metastasis from colorectal cancer. Curr Colorectal Cancer Rep. 2018;14(1):12–21.CrossRef
7.
Zurück zum Zitat Abedi P, Bayat A, Ghasemzadeh S, Raad M, Pashaiefar H, Ahmadvand M Upregulation of miR-410 is linked with unfavorable prognosis in patients with colorectal cancer. British journal of biomedical science. 2020 Abedi P, Bayat A, Ghasemzadeh S, Raad M, Pashaiefar H, Ahmadvand M Upregulation of miR-410 is linked with unfavorable prognosis in patients with colorectal cancer. British journal of biomedical science. 2020
8.
Zurück zum Zitat Bi F, Wang Q, Dong Q, Wang Y, Zhang L, Zhang J. Circulating tumor DNA in colorectal cancer: opportunities and challenges. Am J Transl Res. 2020;12(3):1044–55.PubMedPubMedCentral Bi F, Wang Q, Dong Q, Wang Y, Zhang L, Zhang J. Circulating tumor DNA in colorectal cancer: opportunities and challenges. Am J Transl Res. 2020;12(3):1044–55.PubMedPubMedCentral
9.
Zurück zum Zitat Chee B, Ibrahim F, Esquivel M, Van Seventer EE, Jarnagin JX, Zhang L, Ju JH, Price KS, Raymond VM, Corvera CU, Hirose K, Nakakura EK, Van Loon K, Corcoran RB, Parikh AR, Atreya CE. Circulating tumor derived cell-free DNA (ctDNA) to predict recurrence of metastatic colorectral cancer (mCRC) following curative intent surgery or radiation. J Clin Oncol. 2021;39(15):3562–5. Chee B, Ibrahim F, Esquivel M, Van Seventer EE, Jarnagin JX, Zhang L, Ju JH, Price KS, Raymond VM, Corvera CU, Hirose K, Nakakura EK, Van Loon K, Corcoran RB, Parikh AR, Atreya CE. Circulating tumor derived cell-free DNA (ctDNA) to predict recurrence of metastatic colorectral cancer (mCRC) following curative intent surgery or radiation. J Clin Oncol. 2021;39(15):3562–5.
10.
Zurück zum Zitat Luo H, Zhao Q, Wei W, Zheng L, Yi S, Li G, Wang W, Sheng H, Pu H, Mo H, Zuo Z, Liu Z, Li C, Xie C, Zeng Z, Li W, Hao X, Liu Y, Cao S, Liu W, Gibson S, Zhang K, Xu G, Xu RH Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer. Sci transl Med. 2020;12(524). Luo H, Zhao Q, Wei W, Zheng L, Yi S, Li G, Wang W, Sheng H, Pu H, Mo H, Zuo Z, Liu Z, Li C, Xie C, Zeng Z, Li W, Hao X, Liu Y, Cao S, Liu W, Gibson S, Zhang K, Xu G, Xu RH Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer. Sci transl Med. 2020;12(524).
11.
Zurück zum Zitat Silva-Fisher JM, Dang HX, White NM, Strand MS, Krasnick BA, Rozycki EB et al. Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. Nature Communications. 2020;11(1). Silva-Fisher JM, Dang HX, White NM, Strand MS, Krasnick BA, Rozycki EB et al. Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. Nature Communications. 2020;11(1).
12.
Zurück zum Zitat Shang P, Gao R, Zhu Y, Zhang X, Wang Y, Guo M, et al. VEGFR2-targeted antibody fused with IFNαmut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity. Acta Pharm Sin B. 2021;11(2):420–33.PubMedCrossRef Shang P, Gao R, Zhu Y, Zhang X, Wang Y, Guo M, et al. VEGFR2-targeted antibody fused with IFNαmut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity. Acta Pharm Sin B. 2021;11(2):420–33.PubMedCrossRef
13.
Zurück zum Zitat Taïeb J, André T, El Hajbi F, Barbier E, Toullec C, Kim S, et al. Avelumab versus standard second line treatment chemotherapy in metastatic colorectal cancer patients with microsatellite instability: the SAMCO-PRODIGE 54 randomised phase II trial. Dig Liver Dis. 2021;53(3):318–23.PubMedCrossRef Taïeb J, André T, El Hajbi F, Barbier E, Toullec C, Kim S, et al. Avelumab versus standard second line treatment chemotherapy in metastatic colorectal cancer patients with microsatellite instability: the SAMCO-PRODIGE 54 randomised phase II trial. Dig Liver Dis. 2021;53(3):318–23.PubMedCrossRef
14.•
Zurück zum Zitat Deschamps F, Ronot M, Gelli M, Durand-Labrunie J, Tazdait M, Hollebecque A, et al. Interventional radiology for colorectal liver metastases. Curr Colorectal Cancer Rep. 2020;16(2):29–37. Review of current IR treatments for mCRC.CrossRef Deschamps F, Ronot M, Gelli M, Durand-Labrunie J, Tazdait M, Hollebecque A, et al. Interventional radiology for colorectal liver metastases. Curr Colorectal Cancer Rep. 2020;16(2):29–37. Review of current IR treatments for mCRC.CrossRef
15.
Zurück zum Zitat Van Tilborg AAJM, Meijerink MR, Sietses C, Van Waesberghe JHTM, Mackintosh MO, Meijer S, et al. Long-term results of radiofrequency ablation for unresectable colorectal liver metastases: A potentially curative intervention. Br J Radiol. 2011;84(1002):556–65.PubMedPubMedCentralCrossRef Van Tilborg AAJM, Meijerink MR, Sietses C, Van Waesberghe JHTM, Mackintosh MO, Meijer S, et al. Long-term results of radiofrequency ablation for unresectable colorectal liver metastases: A potentially curative intervention. Br J Radiol. 2011;84(1002):556–65.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Song P, Sheng L, Sun Y, An Y, Guo Y, Zhang Y. The clinical utility and outcomes of microwave ablation for colorectal cancer liver metastases. Oncotarget. 2017;8(31):51792–9.PubMedPubMedCentralCrossRef Song P, Sheng L, Sun Y, An Y, Guo Y, Zhang Y. The clinical utility and outcomes of microwave ablation for colorectal cancer liver metastases. Oncotarget. 2017;8(31):51792–9.PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat James T, Hill J, Fahrbach T, Collins Z. Differences in radiation activity between glass and resin 90y microspheres in treating unresectable hepatic cancer. Health Phys. 2017;112(3):300–4.PubMedCrossRef James T, Hill J, Fahrbach T, Collins Z. Differences in radiation activity between glass and resin 90y microspheres in treating unresectable hepatic cancer. Health Phys. 2017;112(3):300–4.PubMedCrossRef
18.
Zurück zum Zitat Lewandowski RJ, Geschwind JF, Liapi E, Salem R. Transcatheter intraarterial therapies: rationale and overview. Radiol. 2011;259(3):641–57.CrossRef Lewandowski RJ, Geschwind JF, Liapi E, Salem R. Transcatheter intraarterial therapies: rationale and overview. Radiol. 2011;259(3):641–57.CrossRef
19.
Zurück zum Zitat Memon K, Lewandowski RJ, Kulik L, Riaz A, Mulcahy MF, Salem R. Radioembolization for primary and metastatic liver cancer. Semin Radiat Oncol. 2011;21(4):294–302.PubMedPubMedCentralCrossRef Memon K, Lewandowski RJ, Kulik L, Riaz A, Mulcahy MF, Salem R. Radioembolization for primary and metastatic liver cancer. Semin Radiat Oncol. 2011;21(4):294–302.PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Molvar C, Lewandowski RJ. Intra-arterial therapies for liver masses Data Distilled. Radiol Clin North Am. 2015;53(5):973–84.PubMedCrossRef Molvar C, Lewandowski RJ. Intra-arterial therapies for liver masses Data Distilled. Radiol Clin North Am. 2015;53(5):973–84.PubMedCrossRef
21.
Zurück zum Zitat Sacco R, Mismas V, Marceglia S, Romano A, Giacomelli L, Bertini M, et al. Transarterial radioembolization for hepatocellular carcinoma: an update and perspectives. World J Gastroenterol. 2015;21(21):6518–25.PubMedPubMedCentralCrossRef Sacco R, Mismas V, Marceglia S, Romano A, Giacomelli L, Bertini M, et al. Transarterial radioembolization for hepatocellular carcinoma: an update and perspectives. World J Gastroenterol. 2015;21(21):6518–25.PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21(1):109–22.PubMedCrossRef Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21(1):109–22.PubMedCrossRef
23.
Zurück zum Zitat Ibrahim SM, Lewandowski RJ, Sato KT, Gates VL, Kulik L, Mulcahy MF, et al. Radioembolization for the treatment of unresectable hepatocellular carcinoma: a clinical review. World J Gastroenterol. 2008;14(11):1664–9.PubMedPubMedCentralCrossRef Ibrahim SM, Lewandowski RJ, Sato KT, Gates VL, Kulik L, Mulcahy MF, et al. Radioembolization for the treatment of unresectable hepatocellular carcinoma: a clinical review. World J Gastroenterol. 2008;14(11):1664–9.PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Grady ED. Internal radiation therapy of hepatic cancer. Dis Colon Rectum. 1979;22(6):371–5.PubMedCrossRef Grady ED. Internal radiation therapy of hepatic cancer. Dis Colon Rectum. 1979;22(6):371–5.PubMedCrossRef
25.•
Zurück zum Zitat Salem R, Lewandowski R, Roberts C, Goin J, Thurston K, Abouljoud M, et al. Use of Yttrium-90 glass microspheres (TheraSphere) for the treatment of unresectable hepatocellular carcinoma in patients with portal vein thrombosis. J Vasc Interv Radiol. 2004;15(4):335–45. Trial demonstrating glass microspheres safety in unresectable HCC patients with portal vein thrombosis.PubMedCrossRef Salem R, Lewandowski R, Roberts C, Goin J, Thurston K, Abouljoud M, et al. Use of Yttrium-90 glass microspheres (TheraSphere) for the treatment of unresectable hepatocellular carcinoma in patients with portal vein thrombosis. J Vasc Interv Radiol. 2004;15(4):335–45. Trial demonstrating glass microspheres safety in unresectable HCC patients with portal vein thrombosis.PubMedCrossRef
26.
Zurück zum Zitat Salem R, Gordon AC, Mouli S, Hickey R, Kallini J, Gabr A, et al. Y90 radioembolization significantly prolongs time to progression compared with chemoembolization in patients with hepatocellular carcinoma. Gastroenterol. 2016;151(6):1155-63.e2.CrossRef Salem R, Gordon AC, Mouli S, Hickey R, Kallini J, Gabr A, et al. Y90 radioembolization significantly prolongs time to progression compared with chemoembolization in patients with hepatocellular carcinoma. Gastroenterol. 2016;151(6):1155-63.e2.CrossRef
27.
Zurück zum Zitat Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, et al. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial. Lancet Oncol. 2017;18(12):1624–36.PubMedCrossRef Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, et al. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial. Lancet Oncol. 2017;18(12):1624–36.PubMedCrossRef
28.
Zurück zum Zitat Chow PKH, Gandhi M, Tan SB, Khin MW, Khasbazar A, Ong J, et al. SIRveNIB: selective internal radiation therapy versus sorafenib in Asia-Pacific patients with hepatocellular carcinoma. J Clin Oncol. 2018;36(19):1913–21.PubMedCrossRef Chow PKH, Gandhi M, Tan SB, Khin MW, Khasbazar A, Ong J, et al. SIRveNIB: selective internal radiation therapy versus sorafenib in Asia-Pacific patients with hepatocellular carcinoma. J Clin Oncol. 2018;36(19):1913–21.PubMedCrossRef
29.
Zurück zum Zitat Ricke J, Sangro B, Amthauer H, Bargellini I, Bartenstein P, De Toni E, et al. The impact of combining selective internal radiation therapy (SIRT) with sorafenib on overall survival in patients with advanced hepatocellular carcinoma: the soramic trial palliative cohort. J Hepatol. 2018;68:S102.CrossRef Ricke J, Sangro B, Amthauer H, Bargellini I, Bartenstein P, De Toni E, et al. The impact of combining selective internal radiation therapy (SIRT) with sorafenib on overall survival in patients with advanced hepatocellular carcinoma: the soramic trial palliative cohort. J Hepatol. 2018;68:S102.CrossRef
30.
Zurück zum Zitat Van Hazel GA, Heinemann V, Sharma NK, Findlay MPN, Ricke J, Peeters M, et al. SIRFLOX: randomized phase III trial comparing first-line mFOLFOX6 (plus or minus bevacizumab) versus mFOLFOX6 (plus or minus bevacizumab) plus selective internal radiation therapy in patients with metastatic colorectal cancer. J Clin Oncol. 2016;34(15):1723–31.PubMedCrossRef Van Hazel GA, Heinemann V, Sharma NK, Findlay MPN, Ricke J, Peeters M, et al. SIRFLOX: randomized phase III trial comparing first-line mFOLFOX6 (plus or minus bevacizumab) versus mFOLFOX6 (plus or minus bevacizumab) plus selective internal radiation therapy in patients with metastatic colorectal cancer. J Clin Oncol. 2016;34(15):1723–31.PubMedCrossRef
31.
Zurück zum Zitat Khatib J, Kainthla R. Optimal use of FOLFOXIRI plus bevacizumab as first-line systemic treatment in metastatic colorectal cancer. Curr Colorectal Cancer Rep. 2020;16(4):89–95.CrossRef Khatib J, Kainthla R. Optimal use of FOLFOXIRI plus bevacizumab as first-line systemic treatment in metastatic colorectal cancer. Curr Colorectal Cancer Rep. 2020;16(4):89–95.CrossRef
32.•
Zurück zum Zitat Core JM, Frey GT, Sharma A, Bussone ST, Legout JD, McKinney JM, et al. Increasing yttrium-90 dose conformality using proximal radioembolization enabled by distal angiosomal truncation for the treatment of hepatic malignancy. J Vasc Interv Radiol. 2020;31(6):934–42. Use of voxel-based dosimetry in Y90 treatment.PubMedCrossRef Core JM, Frey GT, Sharma A, Bussone ST, Legout JD, McKinney JM, et al. Increasing yttrium-90 dose conformality using proximal radioembolization enabled by distal angiosomal truncation for the treatment of hepatic malignancy. J Vasc Interv Radiol. 2020;31(6):934–42. Use of voxel-based dosimetry in Y90 treatment.PubMedCrossRef
33.
Zurück zum Zitat Morán V, Prieto E, Sancho L, Rodríguez-Fraile M, Soria L, Zubiria A et al. Impact of the dosimetry approach on the resulting 90Y radioembolization planned absorbed doses based on 99mTc-MAA SPECT-CT: is there agreement between dosimetry methods? EJNMMI Physics. 2020;7(1) Morán V, Prieto E, Sancho L, Rodríguez-Fraile M, Soria L, Zubiria A et al. Impact of the dosimetry approach on the resulting 90Y radioembolization planned absorbed doses based on 99mTc-MAA SPECT-CT: is there agreement between dosimetry methods? EJNMMI Physics. 2020;7(1)
34.
Zurück zum Zitat Skanjeti A, Magand N, Defez D, Tordo J, Rode A, Manichon AF et al. Selective internal radiation therapy of hepatic tumors: morphologic and functional imaging for voxel-based computer-aided dosimetry. Biomed Pharm. 2020;132. Skanjeti A, Magand N, Defez D, Tordo J, Rode A, Manichon AF et al. Selective internal radiation therapy of hepatic tumors: morphologic and functional imaging for voxel-based computer-aided dosimetry. Biomed Pharm. 2020;132.
35.
Zurück zum Zitat Ahmadzadehfar H, Sabet A, Biermann K, Muckle M, Brockmann H, Kuhl C, et al. The significance of 99mTc-MAA SPECT/CT liver perfusion imaging in treatment planning for 90Y-microsphere selective internal radiation treatment. J Nucl Med. 2010;51(8):1206–12.PubMedCrossRef Ahmadzadehfar H, Sabet A, Biermann K, Muckle M, Brockmann H, Kuhl C, et al. The significance of 99mTc-MAA SPECT/CT liver perfusion imaging in treatment planning for 90Y-microsphere selective internal radiation treatment. J Nucl Med. 2010;51(8):1206–12.PubMedCrossRef
36.
Zurück zum Zitat Abbott E, Young RS, Hale C, Mitchell K, Falzone N, Vallis KA et al. Stereotactic inverse dose planning after yttrium-90 selective internal radiation therapy in hepatocellular cancer. Adv Rad Oncol. 2021;6(2). Abbott E, Young RS, Hale C, Mitchell K, Falzone N, Vallis KA et al. Stereotactic inverse dose planning after yttrium-90 selective internal radiation therapy in hepatocellular cancer. Adv Rad Oncol. 2021;6(2).
37.
38.
Zurück zum Zitat Kafrouni M, Allimant C, Fourcade M, Vauclin S, Delicque J, Ilonca AD, et al. Retrospective voxel-based dosimetry for assessing the ability of the body-surface-area model to predict delivered dose and radioembolization outcome. J Nucl Med. 2018;59(8):1289–95.PubMedCrossRef Kafrouni M, Allimant C, Fourcade M, Vauclin S, Delicque J, Ilonca AD, et al. Retrospective voxel-based dosimetry for assessing the ability of the body-surface-area model to predict delivered dose and radioembolization outcome. J Nucl Med. 2018;59(8):1289–95.PubMedCrossRef
39.
Zurück zum Zitat Haverkamp BT, Pedersen WR, Hunt S, Walter C, Hill JD, Collins ZC. Tumor response time to progression and progression-free survival in glass versus resin radioembolization of hepatocellular cancer. J Vasc Int Radiol. 2017;28(2):e22. Haverkamp BT, Pedersen WR, Hunt S, Walter C, Hill JD, Collins ZC. Tumor response time to progression and progression-free survival in glass versus resin radioembolization of hepatocellular cancer. J Vasc Int Radiol. 2017;28(2):e22.
40.
Zurück zum Zitat Ibrahim SM, Nikolaidis P, Miller FH, Lewandowski RJ, Ryu RK, Sato KT, et al. Radiologic findings following Y90 radioembolization for primary liver malignancies. Abdom Imaging. 2009;34(5):566–81.PubMedCrossRef Ibrahim SM, Nikolaidis P, Miller FH, Lewandowski RJ, Ryu RK, Sato KT, et al. Radiologic findings following Y90 radioembolization for primary liver malignancies. Abdom Imaging. 2009;34(5):566–81.PubMedCrossRef
41.
Zurück zum Zitat Kennedy AS, Salem R. Radioembolization (yttrium-90 microspheres) for primary and metastatic hepatic malignancies. Cancer J. 2010;16(2):163–75.PubMedCrossRef Kennedy AS, Salem R. Radioembolization (yttrium-90 microspheres) for primary and metastatic hepatic malignancies. Cancer J. 2010;16(2):163–75.PubMedCrossRef
42.
Zurück zum Zitat DeBacker SJJ, Vavricek J, Iqbal S, Hunt SL et al. Retrospective review of survival outcomes in glass and resin Y-90 microsphere treatment of hepatic malignancies. J Int Radiol Nucl Med. 2018:1–9. DeBacker SJJ, Vavricek J, Iqbal S, Hunt SL et al. Retrospective review of survival outcomes in glass and resin Y-90 microsphere treatment of hepatic malignancies. J Int Radiol Nucl Med. 2018:1–9.
43.
Zurück zum Zitat Chiesa C, Mira M, Maccauro M, Romito R, Spreafico C, Sposito C, et al. A dosimetric treatment planning strategy in radioembolization of hepatocarcinoma with90Y glass microspheres. Q J Nucl Med Mol Imaging. 2012;56(6):503–8.PubMed Chiesa C, Mira M, Maccauro M, Romito R, Spreafico C, Sposito C, et al. A dosimetric treatment planning strategy in radioembolization of hepatocarcinoma with90Y glass microspheres. Q J Nucl Med Mol Imaging. 2012;56(6):503–8.PubMed
44.
Zurück zum Zitat Kunam V, Shrikanthan S, Srinivas S. Radiation dosimetry of glass versus resin Y-90 microsphere radioembolization in patients with colorectal liver metastases. J Nucl Med. 2012;53(supplement 1):1203. Kunam V, Shrikanthan S, Srinivas S. Radiation dosimetry of glass versus resin Y-90 microsphere radioembolization in patients with colorectal liver metastases. J Nucl Med. 2012;53(supplement 1):1203.
45.
Zurück zum Zitat Vente MAD, Wondergem M, van der Tweel I, van den Bosch MAAJ, Zonnenberg BA, Lam MGEH, et al. Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis. Eur Radiol. 2009;19(4):951–9.PubMedCrossRef Vente MAD, Wondergem M, van der Tweel I, van den Bosch MAAJ, Zonnenberg BA, Lam MGEH, et al. Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis. Eur Radiol. 2009;19(4):951–9.PubMedCrossRef
46.
Zurück zum Zitat Biederman DM, Titano JJ, Bishay VL, Durrani RJ, Dayan E, Tabori N, et al. Radiation segmentectomy versus Tace combined with microwave ablation for unresectable solitary hepatocellular carcinoma up to 3 cm: a propensity score matching study. Radiol. 2017;283(3):895–905.CrossRef Biederman DM, Titano JJ, Bishay VL, Durrani RJ, Dayan E, Tabori N, et al. Radiation segmentectomy versus Tace combined with microwave ablation for unresectable solitary hepatocellular carcinoma up to 3 cm: a propensity score matching study. Radiol. 2017;283(3):895–905.CrossRef
47.
Zurück zum Zitat PMA approval for TheraSphere™, 21 CFR 814.39(a)(7) (2021). PMA approval for TheraSphere™, 21 CFR 814.39(a)(7) (2021).
48.
Zurück zum Zitat Medical S. A Prospective, multicenter, open-label single arm study evaluating the safety & efficacy of selective internal radiation therapy using SIR-spheres® Y-90 resin microspheres on DoR & ORR in unresectable hepatocellular carcinoma patients clinicaltrials.gov2021 [updated March 23, 2021. Medical S. A Prospective, multicenter, open-label single arm study evaluating the safety & efficacy of selective internal radiation therapy using SIR-spheres® Y-90 resin microspheres on DoR & ORR in unresectable hepatocellular carcinoma patients clinicaltrials.gov2021 [updated March 23, 2021.
49.
Zurück zum Zitat Rizzo S, Botta F, Raimondi S, Origgi D, Fanciullo C, Morganti AG, et al. Radiomics: the facts and the challenges of image analysis. Eur Radiol Exp. 2018;2(1):36.PubMedPubMedCentralCrossRef Rizzo S, Botta F, Raimondi S, Origgi D, Fanciullo C, Morganti AG, et al. Radiomics: the facts and the challenges of image analysis. Eur Radiol Exp. 2018;2(1):36.PubMedPubMedCentralCrossRef
50.
Zurück zum Zitat Creasy JM, Cunanan KM, Chakraborty J, McAuliffe JC, Chou J, Gonen M, et al. Differences in liver parenchyma are measurable with CT radiomics at initial colon resection in patients that develop hepatic metastases from stage II/III colon cancer. Ann Surg Oncol. 2021;28(4):1982–9.PubMedCrossRef Creasy JM, Cunanan KM, Chakraborty J, McAuliffe JC, Chou J, Gonen M, et al. Differences in liver parenchyma are measurable with CT radiomics at initial colon resection in patients that develop hepatic metastases from stage II/III colon cancer. Ann Surg Oncol. 2021;28(4):1982–9.PubMedCrossRef
51.
Zurück zum Zitat Wei L, Cui C, Xu J, Kaza R, El Naqa I, Dewaraja YK. Tumor response prediction in 90Y radioembolization with PET-based radiomics features and absorbed dose metrics. EJNMMI Physics. 2020;7(1). Wei L, Cui C, Xu J, Kaza R, El Naqa I, Dewaraja YK. Tumor response prediction in 90Y radioembolization with PET-based radiomics features and absorbed dose metrics. EJNMMI Physics. 2020;7(1).
52.
Zurück zum Zitat Eisenhauer EA, Verweij J. New response evaluation criteria in solid tumors: RECIST guideline version 1.1. Eur J Cancer. 2009;7(2–3):5.CrossRef Eisenhauer EA, Verweij J. New response evaluation criteria in solid tumors: RECIST guideline version 1.1. Eur J Cancer. 2009;7(2–3):5.CrossRef
53.•
Zurück zum Zitat Dohan A, Gallix B, Guiu B, Le Malicot K, Reinhold C, Soyer P, et al. Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab. Gut. 2020;69(3):531–9. Evaluated the use of radiomics to predict outcomes in patients with mCRC.PubMedCrossRef Dohan A, Gallix B, Guiu B, Le Malicot K, Reinhold C, Soyer P, et al. Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab. Gut. 2020;69(3):531–9. Evaluated the use of radiomics to predict outcomes in patients with mCRC.PubMedCrossRef
54.•
Zurück zum Zitat Shur J, Orton M, Connor A, Fischer S, Moulton CA, Gallinger S, et al. A clinical-radiomic model for improved prognostication of surgical candidates with colorectal liver metastases. J Surg Oncol. 2020;121(2):357–64. Association between clinical features, radiomic features and a combined CRM based on medical imaging.CrossRef Shur J, Orton M, Connor A, Fischer S, Moulton CA, Gallinger S, et al. A clinical-radiomic model for improved prognostication of surgical candidates with colorectal liver metastases. J Surg Oncol. 2020;121(2):357–64. Association between clinical features, radiomic features and a combined CRM based on medical imaging.CrossRef
55.
Zurück zum Zitat Saini A, Wallace A, Alzubaidi S, Knuttinen MG, Naidu S, Sheth R et al. History and evolution of Yttrium-90 radioembolization for hepatocellular carcinoma. J Clin Med. 2019;8(1). Saini A, Wallace A, Alzubaidi S, Knuttinen MG, Naidu S, Sheth R et al. History and evolution of Yttrium-90 radioembolization for hepatocellular carcinoma. J Clin Med. 2019;8(1).
Metadaten
Titel
Liver-Directed Therapy for Metastatic Colon Cancer: Update
verfasst von
John J. Waddell
Patricia H. Townsend
Zachary S. Collins
Carissa Walter
Publikationsdatum
23.03.2022
Verlag
Springer US
Erschienen in
Current Colorectal Cancer Reports / Ausgabe 1/2022
Print ISSN: 1556-3790
Elektronische ISSN: 1556-3804
DOI
https://doi.org/10.1007/s11888-022-00474-1

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.