Skip to main content
Erschienen in: Pediatric Nephrology 6/2018

23.06.2017 | Educational Review

Liver involvement in kidney disease and vice versa

verfasst von: Karen Van Hoeve, Djalila Mekahli, Eva Morava, Elena Levtchenko, Peter Witters

Erschienen in: Pediatric Nephrology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

The liver and kidneys are often similarly affected by a single disease. This is the case in metabolic, immunological, toxic, and infectious diseases, and in the different congenital malformation syndromes. Also, an enzymatic defect in an otherwise healthy liver or the consequences of advanced liver disease by itself can cause kidney disease as a secondary phenomenon. In this review, we describe numerous pathogenic mechanisms leading to dysfunction or malformations of the liver and kidneys in children. We encourage multidisciplinary management for optimal care. A combined liver–kidney transplantation is sometimes needed.
Literatur
1.
Zurück zum Zitat Matloff RG, Arnon R (2015) The kidney in pediatric liver disease. Curr Gastroenterol Rep 17:36CrossRefPubMed Matloff RG, Arnon R (2015) The kidney in pediatric liver disease. Curr Gastroenterol Rep 17:36CrossRefPubMed
2.
Zurück zum Zitat Bacchetta J, Mekahli D, Rivet C, Demède D, Leclerc AL (2015) Pediatric combined liver-kidney transplantation: a 2015 update. Curr Opin Organ Transplant 20:543–549CrossRefPubMed Bacchetta J, Mekahli D, Rivet C, Demède D, Leclerc AL (2015) Pediatric combined liver-kidney transplantation: a 2015 update. Curr Opin Organ Transplant 20:543–549CrossRefPubMed
3.
Zurück zum Zitat Vajro P, Maddaluno S, Veropalumbo C (2013) Persistent hypertransaminasemia in asymptomatic children: a stepwise approach. World J Gastroenterol 14:2740–2751CrossRef Vajro P, Maddaluno S, Veropalumbo C (2013) Persistent hypertransaminasemia in asymptomatic children: a stepwise approach. World J Gastroenterol 14:2740–2751CrossRef
5.
Zurück zum Zitat Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ (2017) Guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 64:154–168CrossRefPubMed Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ (2017) Guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 64:154–168CrossRefPubMed
6.
Zurück zum Zitat Narkewicz MR, Dell Olio D, Karpen SJ, Murray KF, Schwarz K, Yazigi N, Zhang S, Belle SH, Squires RH, Pediatric Acute Liver Failure Study Group (2009) Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement. J Pediatr 155:801–806CrossRefPubMedPubMedCentral Narkewicz MR, Dell Olio D, Karpen SJ, Murray KF, Schwarz K, Yazigi N, Zhang S, Belle SH, Squires RH, Pediatric Acute Liver Failure Study Group (2009) Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement. J Pediatr 155:801–806CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Rock N, McLin V (2014) Liver involvement in children with ciliopathies. Clin Res Hepatol Gastroenterol 38:407–414CrossRefPubMed Rock N, McLin V (2014) Liver involvement in children with ciliopathies. Clin Res Hepatol Gastroenterol 38:407–414CrossRefPubMed
8.
Zurück zum Zitat Gunay-Aygun M (2009) Liver and kidney disease in ciliopathies. Am J Med Genet C Semin Med Genet 15:296–306CrossRef Gunay-Aygun M (2009) Liver and kidney disease in ciliopathies. Am J Med Genet C Semin Med Genet 15:296–306CrossRef
9.
Zurück zum Zitat Büscher R, Büscher AK, Weber S, Mohr J, Hegen B, Vester U, Hoyer PF (2014) Clinical manifestations of autosomal recessive polycystic kidney disease (ARPKD): kidney-related and non-kidney-related phenotypes. Pediatr Nephrol 29:1915–1925CrossRefPubMed Büscher R, Büscher AK, Weber S, Mohr J, Hegen B, Vester U, Hoyer PF (2014) Clinical manifestations of autosomal recessive polycystic kidney disease (ARPKD): kidney-related and non-kidney-related phenotypes. Pediatr Nephrol 29:1915–1925CrossRefPubMed
10.
Zurück zum Zitat Rawat D, Kelly DA, Milford DV, Sharif K, Lloyd C, McKiernan PJ (2013) Phenotypic variation and long-term outcome in children with congenital hepatic fibrosis. J Pediatr Gastroenterol Nutr 57:161–166CrossRefPubMed Rawat D, Kelly DA, Milford DV, Sharif K, Lloyd C, McKiernan PJ (2013) Phenotypic variation and long-term outcome in children with congenital hepatic fibrosis. J Pediatr Gastroenterol Nutr 57:161–166CrossRefPubMed
11.
Zurück zum Zitat Mekahli D, van Stralen KJ, Bonthuis M, Jager KJ, Balat A, Benetti E, Godefroid N, Edvardsson VO, Heaf JG, Jankauskiene A, Kerecuk L, Marinova S, Puteo F, Seeman T, Zurowska A, Pirenne J, Schaefer F, Groothoff JW, ESPN/ERA-EDTA Registry (2016) Kidney versus combined kidney and liver transplantation in young people with autosomal recessive polycystic kidney disease: data from the European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant (ESPN/ERA-EDTA) registry. Am J Kidney Dis 68:782–788CrossRefPubMed Mekahli D, van Stralen KJ, Bonthuis M, Jager KJ, Balat A, Benetti E, Godefroid N, Edvardsson VO, Heaf JG, Jankauskiene A, Kerecuk L, Marinova S, Puteo F, Seeman T, Zurowska A, Pirenne J, Schaefer F, Groothoff JW, ESPN/ERA-EDTA Registry (2016) Kidney versus combined kidney and liver transplantation in young people with autosomal recessive polycystic kidney disease: data from the European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant (ESPN/ERA-EDTA) registry. Am J Kidney Dis 68:782–788CrossRefPubMed
12.
Zurück zum Zitat Ebner K, Feldkoetter M, Ariceta G, Bergmann C, Buettner R, Doyon A, Duzova A, Goebel H, Haffner D, Hero B, Hoppe B, Illig T, Jankauskiene A, Klopp N, König J, Litwin M, Mekahli D, Ranchin B, Sander A, Testa S, Weber LT, Wicher D, Yuzbasioglu A, Zerres K, Dötsch J, Schaefer F, Liebau MC, ESCAPE Study Group; GPN Study Group (2015) Rationale, design and objectives of ARegPKD, a European ARPKD registry study. BMC Nephrol 16:1–7CrossRef Ebner K, Feldkoetter M, Ariceta G, Bergmann C, Buettner R, Doyon A, Duzova A, Goebel H, Haffner D, Hero B, Hoppe B, Illig T, Jankauskiene A, Klopp N, König J, Litwin M, Mekahli D, Ranchin B, Sander A, Testa S, Weber LT, Wicher D, Yuzbasioglu A, Zerres K, Dötsch J, Schaefer F, Liebau MC, ESCAPE Study Group; GPN Study Group (2015) Rationale, design and objectives of ARegPKD, a European ARPKD registry study. BMC Nephrol 16:1–7CrossRef
13.
Zurück zum Zitat Mekahli D, Woolf AS, Bockenhauer D (2010) Similar renal outcomes in children with ADPKD diagnosed by screening or presenting with symptoms. Pediatr Nephrol 25:2275–2282CrossRefPubMed Mekahli D, Woolf AS, Bockenhauer D (2010) Similar renal outcomes in children with ADPKD diagnosed by screening or presenting with symptoms. Pediatr Nephrol 25:2275–2282CrossRefPubMed
14.
Zurück zum Zitat Bae KT, Zhu F, Chapman AB, Torres VE, Grantham JJ, Guay-Woodford LM, Baumgarten DA, King BF Jr, Wetzel LH, Kenney PJ, Brummer ME, Bennett WM, Klahr S, Meyers CM, Zhang X, Thompson PA, Miller JP, Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) (2006) Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the consortium for radiologic imaging studies of polycystic kidney disease cohort. Clin J Am Soc Nephrol 1:64–69CrossRefPubMed Bae KT, Zhu F, Chapman AB, Torres VE, Grantham JJ, Guay-Woodford LM, Baumgarten DA, King BF Jr, Wetzel LH, Kenney PJ, Brummer ME, Bennett WM, Klahr S, Meyers CM, Zhang X, Thompson PA, Miller JP, Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) (2006) Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the consortium for radiologic imaging studies of polycystic kidney disease cohort. Clin J Am Soc Nephrol 1:64–69CrossRefPubMed
15.
Zurück zum Zitat Mekahli D, Parys JB, Bultynck G, Missiaen L, De Smedt H (2013) Polycystins and cellular Ca2+ signaling. Cell Mol Life Sci 70:2697–2712CrossRefPubMed Mekahli D, Parys JB, Bultynck G, Missiaen L, De Smedt H (2013) Polycystins and cellular Ca2+ signaling. Cell Mol Life Sci 70:2697–2712CrossRefPubMed
16.
Zurück zum Zitat Sommerer C, Zeier M (2016) Clinical manifestation and management of ADPKD in western countries. Kidney Dis (Basel) 2:120–127CrossRef Sommerer C, Zeier M (2016) Clinical manifestation and management of ADPKD in western countries. Kidney Dis (Basel) 2:120–127CrossRef
17.
Zurück zum Zitat Watkins PB, Lewis JH, Kaplowitz N, Alpers DH, Blais JD, Smotzer DM, Krasa H, Ouyang J, Torres VE, Czerwiec FS, Zimmer CA (2015) Clinical pattern of tolvaptan-associated liver injury in subjects with autosomal dominant polycystic kidney disease: analysis of clinical trials database. Drug Saf 38:1103–1113CrossRefPubMedPubMedCentral Watkins PB, Lewis JH, Kaplowitz N, Alpers DH, Blais JD, Smotzer DM, Krasa H, Ouyang J, Torres VE, Czerwiec FS, Zimmer CA (2015) Clinical pattern of tolvaptan-associated liver injury in subjects with autosomal dominant polycystic kidney disease: analysis of clinical trials database. Drug Saf 38:1103–1113CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Bockenhauer D, Jaureguiberry G (2016) HNF1B-associated clinical phenotypes: the kidney and beyond. Pediatr Nephrol 31:707–714CrossRefPubMed Bockenhauer D, Jaureguiberry G (2016) HNF1B-associated clinical phenotypes: the kidney and beyond. Pediatr Nephrol 31:707–714CrossRefPubMed
19.
Zurück zum Zitat Chen YZ, Gao Q, Zhao XZ, Chen YZ, Bennett CL, Xiong XS, Mei CL, Shi YQ, Chen XM (2010) Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome/maturity onset diabetes of the young type 5. Chin Med J 123:3326–3333PubMed Chen YZ, Gao Q, Zhao XZ, Chen YZ, Bennett CL, Xiong XS, Mei CL, Shi YQ, Chen XM (2010) Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome/maturity onset diabetes of the young type 5. Chin Med J 123:3326–3333PubMed
20.
Zurück zum Zitat Kotalova R, Dusatkova P, Cinek O, Dusatkova L, Dedic T, Seeman T, Lebl J, Pruhova S (2015) Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review. World J Gastroenterol 28:2550–2257CrossRef Kotalova R, Dusatkova P, Cinek O, Dusatkova L, Dedic T, Seeman T, Lebl J, Pruhova S (2015) Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review. World J Gastroenterol 28:2550–2257CrossRef
21.
Zurück zum Zitat Ferrè S, Bongers EM, Sonneveld R, Cornelissen EA, van der Vlag J, van Boekel GA, Wetzels JF, Hoenderop JG, Bindels RJ, Nijenhuis T (2013) Early development of hyperparathyroidism due to loss of PTH transcriptional repression in patients with HNF1β mutations? J Clin Endocrinol Metab 98:4089–4096CrossRefPubMed Ferrè S, Bongers EM, Sonneveld R, Cornelissen EA, van der Vlag J, van Boekel GA, Wetzels JF, Hoenderop JG, Bindels RJ, Nijenhuis T (2013) Early development of hyperparathyroidism due to loss of PTH transcriptional repression in patients with HNF1β mutations? J Clin Endocrinol Metab 98:4089–4096CrossRefPubMed
22.
Zurück zum Zitat Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA (1999) New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. J Med Genet 36:437–446PubMedPubMedCentral Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA (1999) New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. J Med Genet 36:437–446PubMedPubMedCentral
23.
Zurück zum Zitat O’Dea D, Parfrey PS, Harnett JD, Hefferton D, Cramer BC, Green J (1996) The importance of renal impairment in the natural history of Bardet-Biedl syndrome. Am J Kidney Dis 27:776–783CrossRefPubMed O’Dea D, Parfrey PS, Harnett JD, Hefferton D, Cramer BC, Green J (1996) The importance of renal impairment in the natural history of Bardet-Biedl syndrome. Am J Kidney Dis 27:776–783CrossRefPubMed
24.
Zurück zum Zitat Putoux A, Attie-Bitach T, Martinovic J, Gubler MC (2012) Phenotypic variability of Bardet-Biedl syndrome: focusing on the kidney. Pediatr Nephrol 27:7–15CrossRefPubMed Putoux A, Attie-Bitach T, Martinovic J, Gubler MC (2012) Phenotypic variability of Bardet-Biedl syndrome: focusing on the kidney. Pediatr Nephrol 27:7–15CrossRefPubMed
25.
Zurück zum Zitat Branfield Day L, Quammie C, Héon E, Bhan A, Batmanabane V, Dai T, Kamath BM (2015) Liver anomalies as a phenotype parameter of Bardet-Biedl syndrome. Clin Genet 89:507–509CrossRef Branfield Day L, Quammie C, Héon E, Bhan A, Batmanabane V, Dai T, Kamath BM (2015) Liver anomalies as a phenotype parameter of Bardet-Biedl syndrome. Clin Genet 89:507–509CrossRef
26.
27.
Zurück zum Zitat Parisi MA (2009) Clinical and molecular features of Joubert syndrome and related disorders. Am J Med Genet C Semin Med Genet 15:326–340CrossRef Parisi MA (2009) Clinical and molecular features of Joubert syndrome and related disorders. Am J Med Genet C Semin Med Genet 15:326–340CrossRef
28.
Zurück zum Zitat Hildebrandt F, Zhou W (2007) Nephronophthisis-associated ciliopathies. J Am Soc Nephrol 18:1855–1871CrossRefPubMed Hildebrandt F, Zhou W (2007) Nephronophthisis-associated ciliopathies. J Am Soc Nephrol 18:1855–1871CrossRefPubMed
29.
Zurück zum Zitat Lewis SM, Roberts EA, Marcon MA, Harvey E, Phillips MJ, Chuang SA, Buncic JR, Clarke JT (1994) Joubert syndrome with congenital hepatic fibrosis: an entity in the spectrum of oculo-encephalo-hepato-renal disorders. Am J Med Genet 1:419–426CrossRef Lewis SM, Roberts EA, Marcon MA, Harvey E, Phillips MJ, Chuang SA, Buncic JR, Clarke JT (1994) Joubert syndrome with congenital hepatic fibrosis: an entity in the spectrum of oculo-encephalo-hepato-renal disorders. Am J Med Genet 1:419–426CrossRef
30.
Zurück zum Zitat Emerick KM, Rand EB, Goldmuntz E, Krantz ID, Spinner NB, Piccoli DA (1999) Features of Alagille syndrome in 92 patients: frequency and relation to prognosis. Hepatology 29:822–829CrossRefPubMed Emerick KM, Rand EB, Goldmuntz E, Krantz ID, Spinner NB, Piccoli DA (1999) Features of Alagille syndrome in 92 patients: frequency and relation to prognosis. Hepatology 29:822–829CrossRefPubMed
31.
Zurück zum Zitat Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K (2012) Renal anomalies in Alagille syndrome: a disease-defining feature. Am J Med Genet A 158A:85–89CrossRefPubMed Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K (2012) Renal anomalies in Alagille syndrome: a disease-defining feature. Am J Med Genet A 158A:85–89CrossRefPubMed
32.
Zurück zum Zitat Heringer J, Valayannopoulos V, Lund AM, Wijburg FA, Freisinger P, Barić I, Baumgartner MR, Burgard P, Burlina AB, Chapman KA, I Saladelafont EC, Karall D, Mühlhausen C, Riches V, Schiff M, Sykut-Cegielska J, Walter JH, Zeman J, Chabrol B, Kölker S, additional individual contributors of the E-IMD consortium (2016) Impact of age at onset and newborn screening on outcome in organic acidurias. J Inherit Metab Dis 39:341–353 Heringer J, Valayannopoulos V, Lund AM, Wijburg FA, Freisinger P, Barić I, Baumgartner MR, Burgard P, Burlina AB, Chapman KA, I Saladelafont EC, Karall D, Mühlhausen C, Riches V, Schiff M, Sykut-Cegielska J, Walter JH, Zeman J, Chabrol B, Kölker S, additional individual contributors of the E-IMD consortium (2016) Impact of age at onset and newborn screening on outcome in organic acidurias. J Inherit Metab Dis 39:341–353
33.
Zurück zum Zitat Welling L, Bernstein LE, Berry GT, Burlina AB, Eyskens F, Gautschi M, Grünewald S, Gubbels CS, Knerr I, Labrune P, van der Lee JH, MacDonald A, Murphy E, Portnoi PA, Õunap K, Potter NL, Rubio-Gozalbo ME, Spencer JB, Timmers I, Treacy EP, Van Calcar SC, Waisbren SE, Bosch AM, Galactosemia Network (GalNet) (2017) International clinical guideline for the management of classical galactosemia: diagnosis, treatment, and follow-up. J Inherit Metab Dis 40:171–176CrossRefPubMed Welling L, Bernstein LE, Berry GT, Burlina AB, Eyskens F, Gautschi M, Grünewald S, Gubbels CS, Knerr I, Labrune P, van der Lee JH, MacDonald A, Murphy E, Portnoi PA, Õunap K, Potter NL, Rubio-Gozalbo ME, Spencer JB, Timmers I, Treacy EP, Van Calcar SC, Waisbren SE, Bosch AM, Galactosemia Network (GalNet) (2017) International clinical guideline for the management of classical galactosemia: diagnosis, treatment, and follow-up. J Inherit Metab Dis 40:171–176CrossRefPubMed
34.
Zurück zum Zitat Menezes MJ, Guo Y, Zhang J, Riley LG, Cooper ST, Thorburn DR, Li J, Dong D, Li Z, Glessner J, Davis RL, Sue CM, Alexander SI, Arbuckle S, Kirwan P, Keating BJ, Xu X, Hakonarson H, Christodoulou J (2015) Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia. Hum Mol Genet 24:2297–07CrossRefPubMed Menezes MJ, Guo Y, Zhang J, Riley LG, Cooper ST, Thorburn DR, Li J, Dong D, Li Z, Glessner J, Davis RL, Sue CM, Alexander SI, Arbuckle S, Kirwan P, Keating BJ, Xu X, Hakonarson H, Christodoulou J (2015) Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia. Hum Mol Genet 24:2297–07CrossRefPubMed
35.
Zurück zum Zitat Vernon HJ, Sperati CJ, King JD, Poretti A, Miller NR, Sloan JL, Cameron AM, Myers D, Venditti CP, Valle D (2014) A detailed analysis of methylmalonic acid kinetics during hemodialysis and after combined liver/kidney transplantation in a patient with mut (0) methylmalonic acidemia. J Inherit Metab Dis 37:899–907CrossRefPubMedPubMedCentral Vernon HJ, Sperati CJ, King JD, Poretti A, Miller NR, Sloan JL, Cameron AM, Myers D, Venditti CP, Valle D (2014) A detailed analysis of methylmalonic acid kinetics during hemodialysis and after combined liver/kidney transplantation in a patient with mut (0) methylmalonic acidemia. J Inherit Metab Dis 37:899–907CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Ivanova E, De Leo MG, De Matteis MA, Levtchenko E (2014) Cystinosis: clinical presentation, pathogenesis and treatment. Pediatr Endocrinol Rev 12:176–184PubMed Ivanova E, De Leo MG, De Matteis MA, Levtchenko E (2014) Cystinosis: clinical presentation, pathogenesis and treatment. Pediatr Endocrinol Rev 12:176–184PubMed
37.
Zurück zum Zitat Cornelis T, Claes K, Gillard P, Nijs E, Roskams T, Lombaerts R, Nevens F, Cassiman D (2008) Cholestatic liver disease in long-term infantile nephropathic cystinosis. J Gastroenterol Hepatol 23:e428–e431CrossRefPubMed Cornelis T, Claes K, Gillard P, Nijs E, Roskams T, Lombaerts R, Nevens F, Cassiman D (2008) Cholestatic liver disease in long-term infantile nephropathic cystinosis. J Gastroenterol Hepatol 23:e428–e431CrossRefPubMed
38.
Zurück zum Zitat Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (2012) NASPGHAN practice guidelines: diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr 54:838–855CrossRefPubMed Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (2012) NASPGHAN practice guidelines: diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr 54:838–855CrossRefPubMed
39.
Zurück zum Zitat Fabrizi F, Martin P, Cacoub P, Messa P, Donato FM (2015) Treatment of hepatitis C-related kidney disease. Expert Opin Pharmacother 16:1815–1827CrossRefPubMed Fabrizi F, Martin P, Cacoub P, Messa P, Donato FM (2015) Treatment of hepatitis C-related kidney disease. Expert Opin Pharmacother 16:1815–1827CrossRefPubMed
40.
Zurück zum Zitat Sokal EM, Paganelli M, Wirth S, Socha P, Vajro P, Lacaille F, Kelly D, Mieli-Vergani G, European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2013) Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. J Hepatol 59:814–829CrossRefPubMed Sokal EM, Paganelli M, Wirth S, Socha P, Vajro P, Lacaille F, Kelly D, Mieli-Vergani G, European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2013) Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. J Hepatol 59:814–829CrossRefPubMed
41.
Zurück zum Zitat Liao MT, Chang MH, Lin FG, Tsai IJ, Chang YW, Tsau YK (2011) Universal hepatitis B vaccination reduces childhood hepatitis B virus-associated membranous nephropathy. Pediatrics 128:e600–e604PubMed Liao MT, Chang MH, Lin FG, Tsai IJ, Chang YW, Tsau YK (2011) Universal hepatitis B vaccination reduces childhood hepatitis B virus-associated membranous nephropathy. Pediatrics 128:e600–e604PubMed
42.
Zurück zum Zitat Bhasin B, Ürekli HM, Atta MG (2015) Primary and secondary hyperoxaluria: understanding the enigma. World J Nephrol 6:5–244 Bhasin B, Ürekli HM, Atta MG (2015) Primary and secondary hyperoxaluria: understanding the enigma. World J Nephrol 6:5–244
43.
Zurück zum Zitat Cochat P, Liutkus A, Fargue S, Basmaison O, Ranchin B, Rolland MO (2006) Primary hyperoxaluria type 1: still challenging! Pediatr Nephrol 21:1075–1081CrossRefPubMed Cochat P, Liutkus A, Fargue S, Basmaison O, Ranchin B, Rolland MO (2006) Primary hyperoxaluria type 1: still challenging! Pediatr Nephrol 21:1075–1081CrossRefPubMed
44.
Zurück zum Zitat Bergstralh EJ, Monico CG, Lieske JC, Herges RM, Langman CB, Hoppe B, Milliner DS, Investigators IPHR (2010) Transplantation outcomes in primary hyperoxaluria. Am J Transplant 10:2493–2501CrossRefPubMedPubMedCentral Bergstralh EJ, Monico CG, Lieske JC, Herges RM, Langman CB, Hoppe B, Milliner DS, Investigators IPHR (2010) Transplantation outcomes in primary hyperoxaluria. Am J Transplant 10:2493–2501CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Milliner DS, Wilson DM, Smith LH (2001) Phenotypic expression of primary hyperoxaluria: comparative features of types I and II. Kidney Int 59:31–36CrossRefPubMed Milliner DS, Wilson DM, Smith LH (2001) Phenotypic expression of primary hyperoxaluria: comparative features of types I and II. Kidney Int 59:31–36CrossRefPubMed
46.
Zurück zum Zitat Nester CM, Barbour T, de Cordoba SR, Dragon-Durey MA, Fremeaux-Bacchi V, Goodship TH, Kavanagh D, Noris M, Pickering M, Sanchez-Corral P, Skerka C, Zipfel P, Smith RJ (2015) Atypical aHUS: state of the art. Mol Immunol 67:31–42CrossRefPubMed Nester CM, Barbour T, de Cordoba SR, Dragon-Durey MA, Fremeaux-Bacchi V, Goodship TH, Kavanagh D, Noris M, Pickering M, Sanchez-Corral P, Skerka C, Zipfel P, Smith RJ (2015) Atypical aHUS: state of the art. Mol Immunol 67:31–42CrossRefPubMed
47.
Zurück zum Zitat Sinha A, Gulati A, Saini S, Blanc C, Gupta A, Gurjar BS, Saini H, Kotresh ST, Ali U, Bhatia D, Ohri A, Kumar M, Agarwal I, Gulati S, Anand K, Vijayakumar M, Sinha R, Sethi S, Salmona M, George A, Bal V, Singh G, Dinda AK, Hari P, Rath S, Dragon-Durey MA, Bagga A, Indian HUS Registry (2014) Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children. Kidney Int 85:1151–1160CrossRefPubMed Sinha A, Gulati A, Saini S, Blanc C, Gupta A, Gurjar BS, Saini H, Kotresh ST, Ali U, Bhatia D, Ohri A, Kumar M, Agarwal I, Gulati S, Anand K, Vijayakumar M, Sinha R, Sethi S, Salmona M, George A, Bal V, Singh G, Dinda AK, Hari P, Rath S, Dragon-Durey MA, Bagga A, Indian HUS Registry (2014) Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children. Kidney Int 85:1151–1160CrossRefPubMed
48.
Zurück zum Zitat Saland J (2014) Liver-kidney transplantation to cure atypical HUS: still an option post-eculizumab? Pediatr Nephrol 29:329–332CrossRefPubMed Saland J (2014) Liver-kidney transplantation to cure atypical HUS: still an option post-eculizumab? Pediatr Nephrol 29:329–332CrossRefPubMed
49.
Zurück zum Zitat Parman Y, Adams D, Obici L, Galán L, Guergueltcheva V, Suhr OB, Coelho T, European Network for TTR-FAP (ATTReuNET) (2016) Sixty years of transthyretin familial amyloid polyneuropathy (TTR-FAP) in Europe: where are we now? A European network approach to defining the epidemiology and management patterns for TTR-FAP. Curr Opin Neurol 29:S3–S13CrossRefPubMedPubMedCentral Parman Y, Adams D, Obici L, Galán L, Guergueltcheva V, Suhr OB, Coelho T, European Network for TTR-FAP (ATTReuNET) (2016) Sixty years of transthyretin familial amyloid polyneuropathy (TTR-FAP) in Europe: where are we now? A European network approach to defining the epidemiology and management patterns for TTR-FAP. Curr Opin Neurol 29:S3–S13CrossRefPubMedPubMedCentral
50.
Zurück zum Zitat Planté-Bordeneuve V, Said G (2011) Familial amyloid polyneuropathy. Lancet Neurol 10:1086–1097CrossRefPubMed Planté-Bordeneuve V, Said G (2011) Familial amyloid polyneuropathy. Lancet Neurol 10:1086–1097CrossRefPubMed
51.
Zurück zum Zitat Ferreira AC, Nolasco F, Sampaio S, Baptista A, Pessegueiro P, Monteiro E, Barroso E (2012) Orthotopic liver transplantation in familial amyloidotic polyneuropathy is associated with long-term progression of renal disease. Port J Nephrol Hypert 26:199–205 Ferreira AC, Nolasco F, Sampaio S, Baptista A, Pessegueiro P, Monteiro E, Barroso E (2012) Orthotopic liver transplantation in familial amyloidotic polyneuropathy is associated with long-term progression of renal disease. Port J Nephrol Hypert 26:199–205
52.
Zurück zum Zitat Lobato L, Beirão I, Seca R, Pessegueiro H, Rocha MJ, Queiroz J, Gomes M, Henriques AC, Teixeira M, Almeida R (2011) Combined liver-kidney transplantation in familial amyloidotic polyneuropathy TTR V30M: nephrological assessment. Amyloid 18:190–192CrossRefPubMed Lobato L, Beirão I, Seca R, Pessegueiro H, Rocha MJ, Queiroz J, Gomes M, Henriques AC, Teixeira M, Almeida R (2011) Combined liver-kidney transplantation in familial amyloidotic polyneuropathy TTR V30M: nephrological assessment. Amyloid 18:190–192CrossRefPubMed
53.
Zurück zum Zitat Bozanich NK, Kwo PY (2015) Renal insufficiency in the patient with chronic liver disease. Clin Liver Dis 19:45–56CrossRefPubMed Bozanich NK, Kwo PY (2015) Renal insufficiency in the patient with chronic liver disease. Clin Liver Dis 19:45–56CrossRefPubMed
54.
55.
Zurück zum Zitat Kreuzer M, Gähler D, Rakenius AC, Prüfe J, Jack T, Pfister ED, Pape L (2015) Dialysis-dependent acute kidney injury in children with end-stage liver disease: prevalence, dialysis modalities and outcome. Pediatr Nephrol 30:2199–2206CrossRefPubMed Kreuzer M, Gähler D, Rakenius AC, Prüfe J, Jack T, Pfister ED, Pape L (2015) Dialysis-dependent acute kidney injury in children with end-stage liver disease: prevalence, dialysis modalities and outcome. Pediatr Nephrol 30:2199–2206CrossRefPubMed
56.
Zurück zum Zitat Parsons CE, Nelson R, Book LS, Kyle Jensen M (2014) Renal replacement therapy in infants and children with hepatorenal syndrome awaiting liver transplantation: a case–control study. Liver Transpl 20:1468–1474 Parsons CE, Nelson R, Book LS, Kyle Jensen M (2014) Renal replacement therapy in infants and children with hepatorenal syndrome awaiting liver transplantation: a case–control study. Liver Transpl 20:1468–1474
57.
Zurück zum Zitat European Association for the Study of the Liver (2010) EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol 53:397–417CrossRef European Association for the Study of the Liver (2010) EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol 53:397–417CrossRef
58.
Zurück zum Zitat Lata J (2012) Hepatorenal syndrome. World J Gastroenterol 28:4978–4984CrossRef Lata J (2012) Hepatorenal syndrome. World J Gastroenterol 28:4978–4984CrossRef
59.
Zurück zum Zitat Matloff RG, Arnon R, Saland JM (2012) The kidney in pediatric liver transplantation: an updated perspective. Pediatr Transplant 16:818–828CrossRefPubMed Matloff RG, Arnon R, Saland JM (2012) The kidney in pediatric liver transplantation: an updated perspective. Pediatr Transplant 16:818–828CrossRefPubMed
60.
Zurück zum Zitat Cholongitas E, Shusang V, Marelli L, Nair D, Thomas M, Patch D, Burns A, Sweny P, Burroughs AK (2007) Review article: renal function assessment in cirrhosis—difficulties and alternative measurements. Aliment Pharmacol Ther 1:969–978CrossRef Cholongitas E, Shusang V, Marelli L, Nair D, Thomas M, Patch D, Burns A, Sweny P, Burroughs AK (2007) Review article: renal function assessment in cirrhosis—difficulties and alternative measurements. Aliment Pharmacol Ther 1:969–978CrossRef
61.
Zurück zum Zitat Cholongitas E, Marelli L, Kerry A, Senzolo M, Goodier DW, Nair D, Thomas M, Patch D, Burroughs AK (2007) Different methods of creatinine measurement significantly affect MELD scores. Liver Transpl 13:5–529CrossRef Cholongitas E, Marelli L, Kerry A, Senzolo M, Goodier DW, Nair D, Thomas M, Patch D, Burroughs AK (2007) Different methods of creatinine measurement significantly affect MELD scores. Liver Transpl 13:5–529CrossRef
62.
Zurück zum Zitat Skulzacek PA, Szewc RG, Nolan CR, Riley DJ, Lee S, Pergola PE (2003) Prediction of GFR in liver transplant candidates. Am J Kidney Dis 42:1169–1176CrossRef Skulzacek PA, Szewc RG, Nolan CR, Riley DJ, Lee S, Pergola PE (2003) Prediction of GFR in liver transplant candidates. Am J Kidney Dis 42:1169–1176CrossRef
63.
Zurück zum Zitat Ahn HS, Kim YS, Kim SG, Kim HK, Min SK, Jeong SW, Jang JY, Lee SH, Kim HS, Kim BS, Park JM (2012) Cystatin C is a good predictor of hepatorenal syndrome and survival in patients with cirrhosis who have normal serum creatinine levels. Hepatogastroenterology 59:1168–1173PubMed Ahn HS, Kim YS, Kim SG, Kim HK, Min SK, Jeong SW, Jang JY, Lee SH, Kim HS, Kim BS, Park JM (2012) Cystatin C is a good predictor of hepatorenal syndrome and survival in patients with cirrhosis who have normal serum creatinine levels. Hepatogastroenterology 59:1168–1173PubMed
64.
Zurück zum Zitat Samyn M, Cheeseman P, Bevis L, Taylor R, Samaroo B, Buxton-Thomas M, Heaton N, Rela M, Mieli-Vergani G, Dhawan A (2005) Cystatin C, an easy and reliable marker for assessment of renal dysfunction in children with liver disease and after liver transplantation. Liver Transpl 11:344–349CrossRefPubMed Samyn M, Cheeseman P, Bevis L, Taylor R, Samaroo B, Buxton-Thomas M, Heaton N, Rela M, Mieli-Vergani G, Dhawan A (2005) Cystatin C, an easy and reliable marker for assessment of renal dysfunction in children with liver disease and after liver transplantation. Liver Transpl 11:344–349CrossRefPubMed
65.
Zurück zum Zitat Bahirwani R, Reddy KR (2009) Outcomes after liver transplantation: chronic kidney disease. Liver Transpl 15:S70–S74CrossRefPubMed Bahirwani R, Reddy KR (2009) Outcomes after liver transplantation: chronic kidney disease. Liver Transpl 15:S70–S74CrossRefPubMed
66.
Zurück zum Zitat Ojo AO, Held PJ, Port FK, Wolfe RA, Leichtman AB, Young EW, Arndorfer J, Christensen L, Merion RM (2003) Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 4:931–940CrossRef Ojo AO, Held PJ, Port FK, Wolfe RA, Leichtman AB, Young EW, Arndorfer J, Christensen L, Merion RM (2003) Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 4:931–940CrossRef
67.
Zurück zum Zitat Weber ML, Ibrahim HN, Lake JR (2012) Renal dysfunction in liver transplant recipients: evaluation of the critical issues. Liver Transpl 18:1290–1301CrossRefPubMed Weber ML, Ibrahim HN, Lake JR (2012) Renal dysfunction in liver transplant recipients: evaluation of the critical issues. Liver Transpl 18:1290–1301CrossRefPubMed
68.
Zurück zum Zitat Neuberger JM, Mamelok RD, Neuhaus P, Pirenne J, Samuel D, Isoniemi H, Rostaing L, Rimola A, Marshall S, Mayer AD, ReSpECT Study Group (2009) Delayed introduction of reduced-dose tacrolimus, and renal function in liver transplantation: the ‘Respect’ study. Am J Transplant 9:327–336CrossRefPubMed Neuberger JM, Mamelok RD, Neuhaus P, Pirenne J, Samuel D, Isoniemi H, Rostaing L, Rimola A, Marshall S, Mayer AD, ReSpECT Study Group (2009) Delayed introduction of reduced-dose tacrolimus, and renal function in liver transplantation: the ‘Respect’ study. Am J Transplant 9:327–336CrossRefPubMed
69.
Zurück zum Zitat Gunderson A, Said A (2015) Liver disease in kidney transplant recipients. Transplant Rev (Orlando) 29:1–7CrossRef Gunderson A, Said A (2015) Liver disease in kidney transplant recipients. Transplant Rev (Orlando) 29:1–7CrossRef
70.
Zurück zum Zitat Kronsten V, Fitzpatrick E, Baker A (2013) Management of cholestatic pruritus in paediatric patients with Alagille syndrome: the King’s College Hospital experience. J Pediatr Gastroenterol Nutr 57:149–154CrossRefPubMed Kronsten V, Fitzpatrick E, Baker A (2013) Management of cholestatic pruritus in paediatric patients with Alagille syndrome: the King’s College Hospital experience. J Pediatr Gastroenterol Nutr 57:149–154CrossRefPubMed
71.
Zurück zum Zitat Baker A, Stevenson R, Dhawan A, Goncalves I, Socha P, Sokal E (2007) Guidelines for nutritional care for infants with cholestatic liver disease before liver transplantation. Pediatr Transplant 11:825–834CrossRefPubMed Baker A, Stevenson R, Dhawan A, Goncalves I, Socha P, Sokal E (2007) Guidelines for nutritional care for infants with cholestatic liver disease before liver transplantation. Pediatr Transplant 11:825–834CrossRefPubMed
72.
Zurück zum Zitat Giefer MJ, Murray KF, Colletti RB (2011) Pathophysiology, diagnosis, and management of pediatric ascites. J Pediatr Gastroenterol Nutr 52:503–513CrossRefPubMed Giefer MJ, Murray KF, Colletti RB (2011) Pathophysiology, diagnosis, and management of pediatric ascites. J Pediatr Gastroenterol Nutr 52:503–513CrossRefPubMed
73.
Zurück zum Zitat Srinath A, Shneider BL (2012) Congenital hepatic fibrosis and autosomal recessive polycystic kidney disease. J Pediatr Gastroenterol Nutr 54:580–587CrossRefPubMedPubMedCentral Srinath A, Shneider BL (2012) Congenital hepatic fibrosis and autosomal recessive polycystic kidney disease. J Pediatr Gastroenterol Nutr 54:580–587CrossRefPubMedPubMedCentral
74.
Zurück zum Zitat Arya R, Gulati S, Deopujari S (2010) Management of hepatic encephalopathy in children. Postgrad Med J 86:34–41CrossRefPubMed Arya R, Gulati S, Deopujari S (2010) Management of hepatic encephalopathy in children. Postgrad Med J 86:34–41CrossRefPubMed
75.
Zurück zum Zitat Shneider BL, de Ville de Goyet J, Leung DH, Srivastava A, Ling SC, Duché M, McKiernan P, Superina R, Squires RH, Bosch J, Groszmann R, Sarin SK, de Franchis R, Mazariegos GV (2016) Primary prophylaxis of variceal bleeding in children and the role of MesoRex bypass: summary of the Baveno VI pediatric satellite symposium. Hepatology 63:1368–1380CrossRefPubMed Shneider BL, de Ville de Goyet J, Leung DH, Srivastava A, Ling SC, Duché M, McKiernan P, Superina R, Squires RH, Bosch J, Groszmann R, Sarin SK, de Franchis R, Mazariegos GV (2016) Primary prophylaxis of variceal bleeding in children and the role of MesoRex bypass: summary of the Baveno VI pediatric satellite symposium. Hepatology 63:1368–1380CrossRefPubMed
76.
Zurück zum Zitat Shneider BL, Bosch J, de Franchis R, Emre SH, Groszmann RJ, Ling SC, Lorenz JM, Squires RH, Superina RA, Thompson AE, Mazariegos GV, expert panel of the Children’s Hospital of Pittsburgh of UPMC (2012) Portal hypertension in children: expert pediatric opinion on the report of the Baveno v consensus workshop on methodology of diagnosis and therapy in portal hypertension. Pediatr Transplant 16:426–437CrossRefPubMed Shneider BL, Bosch J, de Franchis R, Emre SH, Groszmann RJ, Ling SC, Lorenz JM, Squires RH, Superina RA, Thompson AE, Mazariegos GV, expert panel of the Children’s Hospital of Pittsburgh of UPMC (2012) Portal hypertension in children: expert pediatric opinion on the report of the Baveno v consensus workshop on methodology of diagnosis and therapy in portal hypertension. Pediatr Transplant 16:426–437CrossRefPubMed
77.
Zurück zum Zitat European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 56:908–943CrossRef European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 56:908–943CrossRef
Metadaten
Titel
Liver involvement in kidney disease and vice versa
verfasst von
Karen Van Hoeve
Djalila Mekahli
Eva Morava
Elena Levtchenko
Peter Witters
Publikationsdatum
23.06.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 6/2018
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3715-3

Weitere Artikel der Ausgabe 6/2018

Pediatric Nephrology 6/2018 Zur Ausgabe

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.