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Tumor Biology
Erschienen in: Tumor Biology 3/2016

29.12.2015 | Review

LncRNAs: key players and novel insights into cervical cancer

verfasst von: Li Peng, Xiaoqing Yuan, Binyuan Jiang, Zaili Tang, Guan-Cheng Li

Erschienen in: Tumor Biology | Ausgabe 3/2016

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Abstract

Cervical cancer contributed the second highest number of deaths in female cancers, exceeded only by breast cancer, carrying high risks of morbidity and mortality. There was a great need and urgency in searching novel treatment targets and prognosis biomarkers to improve the survival rate of cervical cancer patients. Many long non-coding RNAs (lncRNAs) were emerging as pivotal regulators in various biological processes and took vitally an effect on the oncogenesis and progression of cervical cancer. In this review, we summarized the origin and overview function of lncRNAs; highlighted the roles of lncRNAs in cervical cancer in terms of prognosis and tumor progression, invasion and metastasis, apoptosis, and radio-resistance; and outlined the molecular mechanisms of lncRNAs in cervical cancer from the aspects of the interaction of lncRNAs with proteins/mRNAs (especially in HPV protein) and miRNAs, as well as RNA N-methyladenosine (m6A) methylation of lncRNAs. Meanwhile, the application of lncRNAs as biomarkers in cervical cancer prognosis and predictors for metastasis was also discussed. An overview of these researches will be valuable for broadening horizons into mechanisms, selection of meritorious biomarkers for diagnosis as well as prognosis, and future targeted therapy of cervical cancer.
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Metadaten
Titel
LncRNAs: key players and novel insights into cervical cancer
verfasst von
Li Peng
Xiaoqing Yuan
Binyuan Jiang
Zaili Tang
Guan-Cheng Li
Publikationsdatum
29.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 3/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4663-9

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