Skip to main content

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

BMC Musculoskeletal Disorders 1/2016

Local pamidronate influences fracture healing in a rodent femur fracture model: an experimental study

BMC Musculoskeletal Disorders > Ausgabe 1/2016
Leif Menzdorf, Matthias Weuster, Tim Klüter, Stefan Brüggemann, Peter Behrendt, Stefanie Fitchen-Oestern, Deike Varoga, Andreas Seekamp, Nicolai Purcz, Claus C Glueer, Thomas Pufe, Sebastian Lippross



Bisphosphonates are a main component in the therapy of osteoporosis and other bone resorptive diseases. Previous studies have shown a positive effect of systemically applied bisphosphonates on fracture healing. Nevertheless high doses are related to side effects like osteonecrosis of the jaw, nephrotoxis and gastrointestinal symptoms. In this study we investigated the effect of locally applied pamidronate on fracture healing.


In a rodent model a simple femur fracture was set in female Wistar rats. We performed intramedullary fixation of the fracture and placed a collagen matrix around the fracture area. One group was treated with pamidronate, the other group with placebo via the matrix.
To investigate the volume and quality of the callus we used micro-CT (μCT) and histology after 14 and 28 days.


Our results show a positive influence of local applied pamidronate on callus volume. After 14 days an insignificant increase of callus volume in the treated animals was seen. 28 days after trauma the increase of callus volume in the treatment group was significantly higher in comparison to the control group. Osteonecrosis was not seen.


Locally applied bisphosphonates increase the callus volume in fracture healing.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2016

BMC Musculoskeletal Disorders 1/2016 Zur Ausgabe



Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, DICOM-Daten, Videos und Abbildungen. » Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.