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Osteoporosis International

Erschienen in:

01.12.2007 | Original Article

Locally applied simvastatin promotes fracture healing in ovariectomized rat

verfasst von: J. W. Wang, S. W. Xu, D. S. Yang, R. K. Lv

Erschienen in: Osteoporosis International | Ausgabe 12/2007

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Abstract

Summary

Simvastatin solution was injected subcutaneously to the site of fractured tibiae of ovariectomized rats. Afterwards healing quality was evaluated by morphologic, radiographic, biomechanical, histological and histomorphometric methods at 1, 2 and 4 weeks after fracture. Results showed that locally applied simvastatin improved fracture healing.

Introduction

Many studies have documented an anabolic effect of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, on undisturbed bone. Reports of their effects, however, on fractured skeletal sytems have been limited. A study was, therefore, conducted to check the effects of statins on fracture healing.

Methods

Simvastatin (10 mg/kg/day) was injected subcutaneously to tissue overlying the site of fractured tibiae of ovariectomized rats for a treatment period of 5 days. Vehicle reagent was used as a control. Healing quality was evaluated at 1, 2 and 4 weeks after fracture.

Results

Compared with that in the vehicle group, the callus cross-section area in simvastatin-treated rats was significantly enlarged by 21.3% (p < 0.05) at 1 week and by 21.5% (p < 0.05) at 2 weeks; new woven bone was relatively substantive and arranged more tightly and regularly at 2 and 4 weeks; and maximal load was increased by 57.5% (p < 0.05) at 2 weeks and by 31.4% (p < 0.05) at 4 weeks. Histomorphometrically, simvastatin was associated with a significant (p < 0.05) increase of mineralization width (MLW), mineralization volume (MLV) and mineral apposition rate (MAR).

Conclusion

The current study suggests that local application of simvastatin could promote fracture healing in ovariectomized rats.

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Titel: Locally applied simvastatin promotes fracture healing in ovariectomized rat
verfasst von: J. W. Wang
S. W. Xu
D. S. Yang
R. K. Lv
Publikationsdatum: 01.12.2007
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 12/2007
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-007-0412-2

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