Background
Methods
Literature search
Inclusion and exclusion criteria
First author | Year | Country | Ethnicity | Source of control | Genotyping methods | Type of cancers | Case | Control | Included in meta-analysis |
---|---|---|---|---|---|---|---|---|---|
Zhang [21] | 2014 | china | Asian | PB | RFLP | ESCC | 1000 | 1000 | Yes |
Bayram [33] | 2015 | Turkey | Caucasian | HB | TaqMan | BC | 123 | 122 | Yes |
Bayram [28] | 2015 | Turkey | Caucasian | HB | TaqMan | GC | 104 | 209 | Yes |
Du [29] | 2015 | china | Asian | HB | Taqman | GC | 753 | 1057 | Yes |
Guo [25] | 2015 | china | Asian | PB | RFLP | GCA | 515 | 654 | Yes |
Xue [22] | 2015 | china | Asian | HB | Taqman | CRC | 1147 | 1203 | Yes |
Yan [31] | 2015 | china | Asian | PB | RFLP | BC | 502 | 504 | Yes |
Bayram [19] | 2016 | Turkey | Caucasian | HB | TaqMan | BC | 123 | 122 | Yes |
Guo [32] | 2016 | china | Asian | HB | MALDI-TOF-MS | CC | 510 | 713 | Yes |
Pan [26] | 2016 | china | Asian | PB | RFLP | GC | 500 | 1000 | Yes |
Qiu [18] | 2016 | china | Asian | HB | Taqman | Ovarian cancer | 190 | 380 | No |
Qiu [24] | 2016 | china | Asian | NA | Taqman | CC | 215 | 430 | No |
Wu [30] | 2016 | china | Asian | NA | MALDI-TOF-MS | EOC | 1000 | 1000 | Yes |
Zhou [38] | 2016 | china | Asian | HB | MALDI-TOF-MS | Osteosarcoma | 500 | 500 | Yes |
Zhu [34] | 2016 | china | Asian | NA | RFLP | PTC | 1000 | 1000 | Yes |
Hu [36] | 2017 | china | Asian | PB | TaqMan | Pancreatic cancer | 416 | 416 | Yes |
Jin [27] | 2017 | china | Asian | HB | TaqMan | CC | 1174 | 1304 | Yes |
Taheri [37] | 2017 | Iran | Caucasian | HB | ARMS-PCR | Prostate cancer | 128 | 250 | Yes |
Ulger [23] | 2017 | Turkey | Caucasian | HB | TaqMan | GC | 105 | 207 | Yes |
Xavier‑Magalhaes [35] | 2017 | Portugal | Caucasian | PB | RFLP | Glioma | 177 | 199 | Yes |
Data extraction
Quality score assessment
Statistical analysis
Results
Characteristics of the published studies
Analysis of quantitative synthesis
Rs920778, rs12826786, and rs7958904 polymorphism and cancer susceptibility
Subgroup | n | Heterozygote vs. Wild-type | Mutation homozygote vs. wild-type | Dominant model | Recessive model | Allelic model | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | P | I 2(%) | OR(95%CI) | P | I2 (%) | OR(95%CI) | P | I2 (%) | OR(95%CI) | P | I2 (%) | OR(95%CI) | P | I2 (%) | ||
rs920778 | ||||||||||||||||
Overall | 12 |
1.298(1.203-1.400)
| 0.000 | 13.0 |
2.289(1.815-2.887)
| 0.000 | 54.3 |
1.422(1.322-1.529)
| 0.000 | 31.1 |
2.028(1.641-2.506)
| 0.000 | 57.9 |
1.414(1.336-1.497)
| 0.000 | 48.2 |
Caucasian | 3 | 0.920(0.688-1.230) | 0.574 | 0.0 | 1.296(0.875-1.920) | 0.196 | 12.7 | 1.004(0.764-1.318) | 0.978 | 0.0 | 1.368(0.960-1.949) | 0.083 | 48.0 | 1.096(0.906-1.326) | 0.343 | 0.0 |
Asian | 9 |
1.331(1.231-1.440)
| 0.000 | 0.0 |
2.558(2.170-3.016)
| 0.000 | 34.1 |
1.460(1.354-1.574)
| 0.000 | 12.2 |
2.214(1.774-2.762)
| 0.000 | 56.0 |
1.450(1.366-1.539)
| 0.000 | 33.7 |
Estrogen-Dependent | 3 | 1.233(0.995-1.528) | 0.056 | 22.7 |
2.397(1.684-3.412)
| 0.000 | 0.0 |
1.435(1.171-1.759)
| 0.001 | 0.0 |
1.969(1.291-3.005)
| 0.002 | 63.1 |
1.449(1.269-1.654)
| 0.000 | 0.0 |
Digestive | 5 |
1.317(1.175-1.477)
| 0.000 | 1.4 |
2.566(1.766-3.727)
| 0.000 | 57.1 |
1.457(1.305-1.625)
| 0.000 | 22.9 |
2.274(1.594-3.244)
| 0.000 | 56.2 |
1.456(1.333-1.590)
| 0.000 | 46.4 |
HB | 4 |
1.310(1.116-1.539)
| 0.001 | 35.9 |
2.237(1.422-3.518)
| 0.000 | 55.7 |
1.470(1.262-1.713)
| 0.000 | 30.4 |
2.090(1.380-3.167)
| 0.001 | 54.1 |
1.470(1.305-1.655)
| 0.000 | 46.5 |
PB | 5 |
1.255(1.108-1.422)
| 0.000 | 5.8 |
2.260(1.486-3.436)
| 0.000 | 62.8 |
1.390(1.234-1.565)
| 0.000 | 32.8 |
1.969(1.367-2.837)
| 0.000 | 69.8 |
1.399(1.280-1.529)
| 0.000 | 49.9 |
TaqMan | 2 | 0.914(0.619-1.349) | 0.651 | 0.0 | 1.475(0.893-2.436) | 0.129 | 39.4 | 1.044(0.723-1.508) | 0.818 | 0.0 | 1.580(0.716-3.487) | 0.257 | 67.4 | 1.166(0.913-1.489) | 0.218 | 0.0 |
RFLP | 9 |
1.314(1.211-1.425)
| 0.000 | 11.6 |
2.385(1.829-3.109)
| 0.000 | 56.7 |
1.431(1.324-1.548)
| 0.000 | 38.1 |
2.061(1.619-2.624)
| 0.000 | 61.0 |
1.425(1.300-1.562)
| 0.000 | 52.9 |
rs4759314 | ||||||||||||||||
Overall | 13 | 1.089(0.996-1.191) | 0.063 | 47.1 | 1.084(0.735-1.599) | 0.683 | 0.0 | 1.088(0.997-1.188) | 0.059 | 47.7 | 1.087(0.738-1.602) | 0.674 | 0.0 | 1.082(0.996-1.175) | 0.062 | 47.4 |
Asian | 12 |
1.104(1.008-1.209)
| 0.034 | 45.9 | 0.985(0.650-1.493) | 0.943 | 0.0 |
1.099(1.005-1.202)
| 0.040 | 49.5 | 0.976(0.644-1.479) | 0.908 | 0.0 | 1.092(0.964-1.237) | 0.168 | 51.4 |
Digestive | 8 | 1.082(0.904-1.296) | 0.390 | 58.2 | 0.801(0.468-1.371) | 0.419 | 0.0 | 1.076(0.897-1.290) | 0.430 | 60.1 | 0.799(0.467-1.367) | 0.413 | 0.0 | 1.065(0.895-1.266) | 0.480 | 60.7 |
Estrogen-dependent | 3 | 1.153(0.978-1.360) | 0.091 | 8.5 | 1.416(0.696-2.883) | 0.338 | 0.0 | 1.163(0.989-1.368) | 0.068 | 20.3 | 1.387(0.682-2.820) | 0.367 | 0.0 | 1.127(0.858-1.480) | 0.057 | 27.6 |
PB | 5 | 0.975(0.829-1.146) | 0.759 | 0.0 | 0.892(0.424-1.878) | 0.763 | 0.0 | 0.972(0.829-1.140) | 0.726 | 0.0 | 0.903(0.430-1.899) | 0.788 | 0.0 | 0.971(0.835-1.129) | 0.699 | 0.0 |
HB | 7 | 1.131(0.925-1.383) | 0.231 | 66.6 | 1.177(0.736-1.880) | 0.497 | 26.0 | 1.141(0.936-1.392) | 0.191 | 66.9 | 1.176(0.737-1.877) | 0.496 | 28.4 | 1.142(0.949-1.374) | 0.159 | 67.0 |
TaqMan | 6 | 1.149(0.916-1.441) | 0.231 | 70.4 | 0.852(0.493-1.470) | 0.565 | 27.1 | 1.142(0.905-1.442) | 0.264 | 73.1 | 0.847(0.491-1.462) | 0.551 | 25.4 | 1.126(0.898-1.412) | 0.303 | 74.6 |
RFLP | 5 | 1.047(0.887-1.236) | 0.589 | 0.0 | 0.953(0.349-2.601) | 0.925 | 0.0 | 1.044(0.886-1.231) | 0.604 | 0.0 | 0.946(0.347-2.582) | 0.914 | 0.0 | 1.040(0.887-1.218) | 0.629 | 0.0 |
rs7958904 | ||||||||||||||||
Overall | 6 |
0.887(0.819-0.961)
| 0.003 | 0.0 | 0.747(0.529-1.056) | 0.098 | 79.2 |
0.869(0.806-0.938)
| 0.000 | 47.4 | 0.787(0.571-1.086) | 0.145 | 77.0 |
0.869(0.769-0.981)
| 0.024 | 73.8 |
Estrogen-dependent | 2 | 0.920(0.813-1.042) | 0.191 | 43.0 | 0.910(0.312-2.653) | 0.863 | 94.5 | 0.911(0.676-1.227) | 0.538 | 84.0 | 0.944(0.345-2.577) | 0.910 | 94.1 | 0.928(0.650-1.325) | 0.682 | 92.6 |
Digestive | 3 |
0.870(0.776-0.975)
| 0.017 | 0.0 |
0.717(0.579-0.888)
| 0.002 | 0.0 |
0.842(0.756-0.939)
| 0.002 | 0.0 |
0.758(0.615-0.933)
| 0.009 | 0.0 |
0.852(0.781-0.930)
| 0.000 | 0.0 |
HB | 5 |
0.899(0.823-0.982)
| 0.018 | 0.0 | 0.804(0.552-1.172) | 0.258 | 78.4 |
0.891(0.819-0.969)
| 0.007 | 48.3 | 0.845(0.596-1.198) | 0.344 | 75.9 | 0.890(0.778-1.019) | 0.091 | 73.4 |
TaqMan | 4 |
0.907(0.826-0.997)
| 0.043 | 0.0 | 0.866(0.568-1.321) | 0.503 | 81.1 | 0.897(0.782-1.028) | 0.118 | 55.5 | 0.904(0.611-1.336) | 0.611 | 79.0 | 0.912(0.783-1.062) | 0.234 | 76.9 |
MALDI-TO F-MS | 2 |
0.838(0.720-0.975)
| 0.022 | 0.0 |
0.538(0.399-0.726)
| 0.000 | 0.0 |
0.783(0.678-0.905)
| 0.001 | 0.0 |
0.577(0.430-0.774)
| 0.000 | 0.0 |
0.779(0.693-0.876)
| 0.000 | 0.0 |
rs1899663 | ||||||||||||||||
Overall | 6 | 0.958(0.862-1.066) | 0.431 | 0.0 | 0.810(0.596-1.101) | 0.179 | 0.0 | 0.942(0.850-1.045) | 0.260 | 0.0 | 0.818(0.608-1.100) | 0.184 | 0.0 | 0.939(0.858-1.027) | 0.166 | 0.0 |
Asian | 5 | 0.950(0.852-1.058) | 0.350 | 0.0 | 0.726(0.512-1.028) | 0.071 | 0.0 | 0.932(0.839-1.036) | 0.193 | 0.0 | 0.735(0.520-1.040) | 0.082 | 0.0 | 0.925(0.842-1.016) | 0.102 | 0.0 |
Estrogen-dependent | 2 | 1.001(0.832-1.205) | 0.991 | 0.0 | 0.746(0.430-1.293) | 0.296 | 0.0 | 0.979(0.818-1.173) | 0.822 | 18.0 | 0.752(0.435-1.301) | 0.308 | 0.0 | 0.961(0.821-1.125) | 0.620 | 23.1 |
Digestive | 2 | 0.973(0.831-1.138) | 0.729 | 0.0 | 0.773(0.463-1.290) | 0.325 | 0.0 | 0.957(0.821-1.116) | 0.576 | 0.0 | 0.775(0.465-1.292) | 0.328 | 0.0 | 0.948(0.826-1.087) | 0.443 | 0.0 |
HB | 2 | 1.106(0.883-1.387) | 0.381 | 0.0 | 1.080(0.638-1.828) | 0.774 | 0.0 | 1.099(0.881-1.369) | 0.403 | 0.0 | 1.022(0.632-1.651) | 0.930 | 0.0 | 1.067(0.892-1.277) | 0.475 | 0.0 |
PB | 3 | 0.956(0.834-1.095) | 0.512 | 0.0 | 0.737(0.487-1.114) | 0.147 | 0.0 | 0.937(0.821-1.069) | 0.334 | 0.0 | 0.746(0.494-1.125) | 0.162 | 0.0 | 0.928(0.825-1.043) | 0.208 | 0.0 |
RFLP | 4 | 0.920(0.816-1.038) | 0.176 | 0.0 | 0.701(0.480-1.024) | 0.066 | 0.0 | 0.903(0.803-1.015) | 0.086 | 0.0 | 0.715(0.491-1.043) | 0.081 | 0.0 |
0.899(0.810-0.997)
| 0.044 | 0.0 |
rs87494 | ||||||||||||||||
Overall | 3 | 1.100((0.989-1.223) | 0.079 | 0.0 | 1.161(0.891-1.512) | 0.269 | 0.0 | 1.106(0.999-1.225) | 0.053 | 0.0 | 1.127(0.867-1.465) | 0.372 | 0.0 |
1.091((1.000-1.191)
| 0.050 | 0.0 |
Digestive | 2 | 1.092(0.955-1.250) | 0.199 | 0.0 | 1.171(0.839-1.635) | 0.353 | 0.0 | 1.101(0.967-1.253) | 0.148 | 0.0 | 1.140(0.819-1.588) | 0.436 | 0.0 | 1.090(0.975-1.218) | 0.132 | 0.0 |
rs12826786 | ||||||||||||||||
Overall | 5 | 1.155(0.971-1.374) | 0.104 | 22.8 |
1.670(1.244-2.242)
| 0.001 | 48.2 |
1.233((1.044-1.456)
| 0.013 | 29.5 |
1.551(1.186-2.027)
| 0.001 | 40.5 |
1.237(1.092-1.401)
| 0.001 | 34.9 |
Caucasian | 4 | 1.092(0.851-1.400) | 0.489 | 36.9 | 1.507(0.903-2.515) | 0.116 | 53.9 | 1.174(0.928-1.485) | 0.181 | 43.2 |
1.433(1.059-1.938)
| 0.020 | 45.6 |
1.196(1.017-1.406)
| 0.030 | 47.8 |
Digestive | 2 | 1.158(0.929-1.443) | 0.191 | 0.0 | 1.595(0.796-3.196) | 0.188 | 58.2 | 1.225(0.991-1.514) | 0.060 | 14.4 |
1.569(1.034-2.378)
| 0.034 | 45.0 |
1.224(1.034-1.448)
| 0.019 | 29.1 |
HB | 4 | 1.183(0.978-1.430) | 0.084 | 37.9 |
1.929(1.392-2.674)
| 0.000 | 16.0 |
1.289(1.074-1.546)
| 0.006 | 31.4 |
1.741(1.299-2.333)
| 0.000 | 4.3 |
1.299(1.134-1.489)
| 0.000 | 2.1 |
TaqMan | 2 | 0.875(0.597-1.283) | 0.494 | 0.0 | 1.512(0.919-2.487) | 0.104 | 47.3 | 1.018(0.711-1.456) | 0.923 | 0.0 | 1.665(0.786-3.527) | 0.183 | 62.4 | 1.169(0.914-1.495) | 0.212 | 19.7 |
RFLP | 2 | 1.169(0.947-1.443) | 0.147 | 0.0 | 1.409(0.549-3.616) | 0.476 | 75.8 | 1.211(0.989-1.484) | 0.064 | 20.4 | 1.344(0.558-3.236) | 0.510 | 73.8 | 1.145(0.856-1.532) | 0.363 | 61.8 |