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Annals of Hematology

Erschienen in:

04.07.2020 | Review Article

Long non-coding RNAs and MYC association in hematological malignancies

verfasst von: Leonidas Benetatos, Agapi Benetatou, Georgios Vartholomatos

Erschienen in: Annals of Hematology | Ausgabe 10/2020

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Abstract

Long non-coding RNAs (lncRNAs) have an established role in cell biology. Among their functions is the regulation of hematopoiesis. They characterize the different stages of hematopoiesis in a more lineage-restricted expression pattern than coding mRNAs. They affect hematopoietic stem cell renewal, proliferation, and differentiation of committed progenitors by interacting with master regulators transcription factors. Among these transcription factors, MYC has a prominent role. Similar to MYC’s transcriptional activation/amplification of protein coding genes, MYC also regulates lncRNAs’ expression profile, while it is also regulated by lncRNAs. Both myeloid and lymphoid malignancies are prone to the association of MYC with lncRNAs. Such interaction inhibits apoptosis, enhances cell proliferation, deregulates metabolism, and promotes genomic instability and resistance to treatment. In this review, we discuss the recent findings that encompass the crosstalk between lncRNAs and describe the pathways that very probably have a pathogenetic role in both acute and chronic hematologic malignancies.

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Titel: Long non-coding RNAs and MYC association in hematological malignancies
verfasst von: Leonidas Benetatos
Agapi Benetatou
Georgios Vartholomatos
Publikationsdatum: 04.07.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Annals of Hematology / Ausgabe 10/2020
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-020-04166-4

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Long non-coding RNAs and MYC association in hematological malignancies

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