Erschienen in:
29.10.2019
Long non-coding RNAs in cardiac hypertrophy
verfasst von:
Jinghui Sun, Chenglong Wang
Erschienen in:
Heart Failure Reviews
|
Ausgabe 6/2020
Einloggen, um Zugang zu erhalten
Abstract
Cardiac hypertrophy (CH) is generally considered adaptive responses that may occur after myocardial infarction, pressure overload, volume overload, inflammatory heart muscle disease, or idiopathic dilated cardiomyopathy, whereas long-term stimulation eventually leads to heart failure (HF). However, the current molecular mechanisms involved in CH are unclear. Recently, increasing evidences reveal that long non-coding RNAs (lncRNAs) play vital roles in CH. Different lncRNAs can promote or inhibit the pathological process of CH by different mechanisms, while the regulation of lncRNAs expression can improve CH. Thus, CH-related lncRNAs may become a novel field of research on CH.