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Cancer and Metastasis Reviews

Erschienen in:

11.12.2017

Long non-coding RNAs in metastasis

verfasst von: Qihong Huang, Jinchun Yan, Reuven Agami

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1/2018

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Abstract

Long non-coding RNA (lncRNA) genes have recently been discovered as key regulators of developmental, physiological, and pathological processes in humans. Recent studies indicate that lncRNAs regulate every step of gene expression, and their aberrant expression can be found in the majority of cancer types. Particularly, lncRNAs were found to function in tumor development and metastasis, which is the major cause of cancer-related death. Thus, exploring key roles of lncRNAs in metastasis is predicted to enhance our knowledge of metastasis, and uncover novel therapeutic targets and biomarkers of this process. In this review, we discuss the molecular mechanisms of lncRNAs in gene expression regulation and their function in metastasis.

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Titel: Long non-coding RNAs in metastasis
verfasst von: Qihong Huang
Jinchun Yan
Reuven Agami
Publikationsdatum: 11.12.2017
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1/2018
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-017-9713-x

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Abstract

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