Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E−/− Mice | springermedizin.de

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Journal of Cardiovascular Translational Research

Erschienen in:

19.03.2019 | Original Article

Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E^−/− Mice

verfasst von: Wei Lu, Xiaoying He, Le Su, Junying Miao

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 5/2019

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Abstract

Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Changes in atherosclerotic plaque composition will lead to acute coronary syndromes. Although the studies on the molecular mechanisms of long noncoding RNA (lncRNA) are in-depth in molecular and cell levels, the in vivo research which studied the knowledge about lncRNAs in the regulation of plaque composition is still sparse. In this study, in order to investigate how a new lncRNA, CERNA1, regulates the composition of atherosclerotic plaques, we overexpressed CERNA1 in apolipoprotein E^−/− (Apo E^−/−) mice and analyzed the role of CERNA1 in atherosclerotic plaque stabilization. The results showed that CERNA1 inhibited the apoptosis of VSMCs and anti-inflammatory macrophages through increasing API5 level and further stabilized the atherosclerotic plaques. This discovery provided a novel therapeutic target for atherosclerosis.

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Titel: Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E−/− Mice
verfasst von: Wei Lu
Xiaoying He
Le Su
Junying Miao
Publikationsdatum: 19.03.2019
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 5/2019
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-019-09883-4

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