Long-term changes in lipid indices following Roux-en-Y gastric bypass: a meta-analysis
- 05.05.2025
- Review Article
Erschienen in:
- Verfasst von
- Tannaz Jamialahamdi
- Elaheh Mirhadi
- Mohammed A. Abdalla
- Kishore M. Gadde
- Wael Almahmeed
- Ali H. Eid
- Saheem Ahmad
- Irfan Ahmad
- Matthew Kroh
- Amirhossein Sahebkar
- Erschienen in
- Surgical Endoscopy | Ausgabe 7/2025
Abstract
Introduction
Bariatric surgery yields clinically significant long-term weight loss accompanied by marked improvements in numerous weight-related comorbidities including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, and fatty liver disease.
Objective
This systematic review and meta-analysis aimed to evaluate the effect of (RYGB) surgery on lipid profile.
Data source
We searched PubMed, Scopus, Web of Science and Scholar from inception to May 20th, 2024.
Studies selection
Clinical studies that reported lipid profile data with a follow-up of at least 5 years after RYGB were eligible.
Data extraction
Two independent reviewers extracted data and assessed the risk of bias.
Results
Of the 4922 articles identified from our database search, 38 studies that measured lipid profile following RYGB were identified and selected for the analysis. Compared to pre-surgery, at post-surgery follow-up of ≥ 5 years, RYGB was associated with significant reductions in mean total cholesterol (TC) (WMD: − 17.95 mg/dl, 95% CI: − 22.68, − 13.22, 95% PI: − 46.18, 10.27 p < 0.001; I2:92.3), LDL-cholesterol (WMD: − 18.55 mg/dl, 95% CI: -21.85, -15.25, 95% PI: − 39.01, 1.92 p < 0.001; I2:91.8), and triglycerides (WMD: − 60.76 mg/dl, 95% CI: − 66.29, − 55.22, 95% PI: − 91.24, − 30.27 p < 0.001; I2:83.7), and increase in HDL-cholesterol (WMD: 13.75 mg/dl, 95% CI: 12.38, 15.13, 95% PI: 5.32, 22.19 p < 0.001; I2:91.4).
Conclusion
RYBG is associated with clinically significant large improvements in serum lipids at a post-operative follow-up of 5 years or more.
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- Titel
- Long-term changes in lipid indices following Roux-en-Y gastric bypass: a meta-analysis
- Verfasst von
-
Tannaz Jamialahamdi
Elaheh Mirhadi
Mohammed A. Abdalla
Kishore M. Gadde
Wael Almahmeed
Ali H. Eid
Saheem Ahmad
Irfan Ahmad
Matthew Kroh
Amirhossein Sahebkar
- Publikationsdatum
- 05.05.2025
- Verlag
- Springer US
- Erschienen in
-
Surgical Endoscopy / Ausgabe 7/2025
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218 - DOI
- https://doi.org/10.1007/s00464-025-11745-x
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