Introduction
Methods
Interviews and development of a provisional questionnaire
Methodological framework and considerations
Setting and study population
Sampling strategies
Interviews
Data analysis
Additional questions
Response scales
Measure | Question | Response scale |
---|---|---|
Incidence | Have you had leakage of stools because of not being able to reach the toilet in time? | No—Occasionally—Once a week—Several times a week—Once a day—Several times a day |
Prevalence | Have you needed help moving between chair and bed | No—Occasionally—Half of the times—Most of the times—Every time |
Intensity | Have you found normal touch bothersome? | Not at all—A little—Moderately—Quite a bit—Very much |
Agreement | Have you had difficulties extending your wrist? | No—Yes |
Content validity and cognitive interviews
Application of the questionnaire
Statistical analysis
Results
Interviews and development of a provisional questionnaire
Study population
ICU survivors (n = 395) | Interviewees (n = 32) | |
---|---|---|
Primary diagnosis, n (%) | ||
Infection/sepsis | 110 (27.8) | 6 (18.8) |
Trauma | 53 (13.4) | 4 (12.5) |
Respiratory failure | 43 (10.9) | 3 (9.4) |
Major bleeding1 | 38 (9.6) | 0 (0.0) |
Cardiac arrest | 24 (6.1) | 4 (12.5) |
GI diseases2 | 17 (4.3) | 3 (9.4) |
Liver failure | 16 (4.1) | 1 (3.1) |
Transplantation | 16 (4.1) | 3 (9.4) |
Postoperative | 16 (4.1) | 1 (3.1) |
Renal failure | 12 (3.0) | 3 (9.4) |
Pulmonary diseases3 | 10 (2.5) | 0 (0.0) |
Cardiac failure and/or myocardial infarction | 10 (2.5) | 2 (6.3) |
Vascular disorders4 | 10 (2.5) | 0 (0.0) |
Metabolic disorders | 8 (2.0) | 0 (0.0) |
Other | 7 (1.8) | 2 (6.3) |
Oncological or haematological disorders | 5 (1.3) | 0 (0.0) |
SAPS3 score | ||
Median (range) | 59 (16–100) | 57.5 (24–81) |
ICU, length of stay | ||
Days, median (range) | 5.5 (3.0–78.6) | 4.9 (1.7–76.1) |
Mechanical ventilation | ||
Patients, n (%) | 310 (78.5) | 23 (69.7) |
Days, median (range) | 5.0 (1.0–74.0) | 5 (1.0–62.0) |
Continuous renal replacement therapy | ||
Patients, n (%) | 88 (22.3) | 11 (33.0) |
Days, median (range) | 6.0 (1.0–42.0) | 8.0 (3.0–53.0) |
Interviews
Data analysis
Additional questions
Domain | Number of questions |
---|---|
Cognitive function | 31 |
Fatigue | 14 |
Physical health | 31 |
Pain | 19 |
Psychological aspects | 29 |
Activities of daily living (ADL) | 16 |
Sleep | 11 |
Appetite and alcohol | 11 |
Sexual health | 14 |
Sensory functions | 26 |
Gastrointestinal functions | 7 |
Urinary functions | 8 |
Work life | 21 |
Total number of questions | 238 |
Response scales
Application of the questionnaires
Demographics and comorbidities
ICU survivors (n = 395) | Controls (n = 195) | p-value | Total (N) | |
---|---|---|---|---|
Age, years; median (IQR) | 65.0 (18) | 65.0 (15) | 0.56 | 589 |
Body mass index; median (IQR) | 26.0 (7) | 25.4 (5) | 0.17 | 555 |
Smoker; n (%*) | 15 (13) | 15 (11) | 0.01 | 109 |
Male; n (%*) | 239 (61) | 117 (60) | ||
Education; n (%*) | 0.132 | 574 | ||
Primary school | 161 (42) | 64 (33) | ||
Secondary school | 85 (22) | 47 (24) | ||
College or University | 125 (33) | 73 (38) | ||
Other | 10 (3) | 9 (5) | ||
Employment status; n (%*) | 0.000 | 570 | ||
Contract and self-employment, parental leave | 79 (21) | 86 (45) | ||
Sickness benefit/sick leave | 88 (23) | 5 (3) | ||
Unemployed (out of work) | 2 (1) | 1 (1) | ||
Student | 2 (1) | 0 (0) | ||
Retired | 206 (55) | 101 (52) | ||
Current form of living; n (%*) | 0.00 | 575 | ||
Hospital | 2 (1) | 0 (0) | ||
Rehab | 3 (1) | 0 (0) | ||
Nursing home | 3 (1) | 0 (0) | ||
Residential home | 13 (3) | 1 (1) | ||
Apartment | 187 (49) | 53 (28) | ||
Detached house | 176 (46) | 137 (72) | ||
Civic status, n (%*) | ||||
Married/partner | 233 (63) | 159 (84) | 0.00 | 545 |
ICU survivors (n = 395) | Controls (n = 195) | p-value | |
---|---|---|---|
Cardiovascular, n (%*) | |||
Hypertension | 183 (50) | 60 (34) | 0.00 |
Angina pectoris | 28 (8) | 5 (3) | 0.03 |
Myocardial infarction | 52 (15) | 4 (2) | 0.00 |
Heart failure | 56 (16) | 11 (6) | 0.00 |
Respiratory, n (%*) | |||
Lung disease, e.g., COPD, bronchitis | 50 (14) | 5 (3) | 0.00 |
Pulmonary embolus | 21 (6) | 1 (1) | 0.00 |
Asthma | 34 (9) | 19 (11) | 0.54 |
Sleep apnoea | 35 (10) | 15 (8) | 0.64 |
Home ventilator | 7 (2) | 0 (0) | 0.10 |
Neurological, n (%*) | |||
Stroke | 34 (9) | 11 (6) | 0.25 |
Dementia/Alzheimer's disease | 2 (1) | 3 (2) | 0.36 |
Multiple sclerosis | 2 (1) | 2 (1) | 0.60 |
Parkinson's disease | 3 (1) | 1 (1) | 1.00 |
Psychiatric, n (%*) | |||
Psychological diseases, e.g., depression, anxiety | 65 (19) | 17 (8) | 0.01 |
Metabolic, n (%*) | |||
Non-insulin-dependent diabetes | 53 (15) | 14 (8) | 0.03 |
Insulin-dependent diabetes | 43 (11) | 4 (2) | 0.00 |
Kidney disease | 33 (8) | 3 (2) | 0.00 |
Dialysis | 6 (2) | 1 (1) | 1,00 |
Other, n (%*) | |||
Tumour disease | 44 (13) | 14 (8) | 0.14 |
Bowel disease | 42 (12) | 10 (6) | 0.03 |
Rheumatic disease | 27 (8) | 9 (5) | 0.28 |
Physical walking aids, n (%*) | |||
Walking stick/crutches | 0 (0) | 0 (0) | N/A |
Walking frame/rollator | 69 (18) | 0 (0) | 0.00 |
Wheelchair/electric wheelchair | 35 (9) | 0 (0) | 0.00 |
Bedridden | 5 (1) | 0 (0) | 0.18 |
Amputated limb(s) | 13 (3) | 0 (0) | 0.01 |
Symptoms and burden of disease
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU survivors | Controls | ICU survivors | Controls | |||
Cog1 | Difficulties finding words | 2.10 | 1.98 | 283.92 | 278.15 | 0.677 |
Cog2 | Difficulties finishing sentences | 1.72 | 1.47 | 291.65 | 265.66 | 0.040 |
Cog3 | Losing the thread easily | 1.88 | 1.46 | 302.73 | 246.23 | 0.000 |
Cog4 | Don't remember what you have said | 1.68 | 1.44 | 293.57 | 260.18 | 0.008 |
Cog5 | Don't remember what you have done | 1.46 | 1.22 | 294.28 | 257.11 | 0.001 |
Cog6 | Think you have done something but you haven't | 1.44 | 1.20 | 296.86 | 256.42 | 0.000 |
Cog7 | Forgotten what you were going to get | 2.30 | 2.11 | 283.64 | 272.82 | 0.427 |
Cog8 | Need to be reminded to do an activity | 1.57 | 1.29 | 265.27 | 236.39 | 0.007 |
Cog9 | Difficulties thinking clearly | 1.93 | 1.60 | 295.96 | 259.70 | 0.007 |
Cog10 | Need for memos | 2.40 | 2.27 | 284.43 | 275.63 | 0.529 |
Cog11 | Difficulties remembering names | 2.39 | 2.36 | 283.09 | 285.84 | 0.845 |
Cog12 | Difficulties remembering general knowledge | 1.69 | 1.63 | 253.68 | 247.39 | 0.599 |
Cog13 | Difficulties remembering what you have read | 1.95 | 1.77 | 272.88 | 260.12 | 0.324 |
Cog14 | Difficulties remembering previous TV-episode | 1.67 | 1.45 | 230.68 | 211.66 | 0.078 |
Cog15 | Difficulties learning new things | 1.71 | 1.50 | 230.61 | 219.21 | 0.287 |
Cog16 | Difficulties remembering numbers | 1.76 | 1.70 | 269.08 | 268.84 | 0.984 |
Cog17 | Difficulties being on time | 1.28 | 1.17 | 270.79 | 258.38 | 0.127 |
Cog18 | Missed a scheduled meeting | 1.14 | 1.04 | 260.82 | 249.87 | 0.064 |
Cog19 | Mistaken which day of the week | 1.77 | 1.41 | 297.31 | 251.46 | 0.000 |
Cog20 | Forgotten where you have put something | 2.26 | 2.34 | 273.42 | 297.58 | 0.082 |
Cog21 | Need to double-check things | 2.09 | 2.08 | 277.60 | 287.75 | 0.461 |
Cog22 | Difficulties finding your way around | 1.51 | 1.38 | 286.37 | 274.76 | 0.263 |
Cog23 | Someone has said that you have memory problems | 1.59 | 1.29 | 295.43 | 259.51 | 0.002 |
Cog24 | Worrying about having memory problems | 1.61 | 1.43 | 288.59 | 270.33 | 0.118 |
Cog25 | Difficulties taking initiatives | 1.89 | 1.53 | 298.98 | 252.38 | 0.000 |
Cog26 | Difficulties prioritizing | 1.73 | 1.59 | 245.72 | 235.74 | 0.378 |
Cog27 | Difficulties concentrating | 2.04 | 1.72 | 293.39 | 261.40 | 0.017 |
Cog28 | Difficulties finding alternative solutions | 1.59 | 1.34 | 234.77 | 208.96 | 0.010 |
Cog29 | Time spent reading* | 2.81 | 2.91 | 274.23 | 288.36 | 0.311 |
Cog30 | Memory/thinking difficulties affecting QoL | 1.80 | 1.40 | 262.02 | 214.63 | 0.000 |
Cog31 | Worrying about your memory/thinking | 1.78 | 1.52 | 295.25 | 266.15 | 0.021 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU survivors | Controls | ICU survivors | Controls | |||
Fat1 | Need for daytime rest | 2.99 | 2.08 | 316.07 | 216.41 | 0.000 |
Fat2 | Tough getting started doing things | 2.72 | 2.09 | 308.67 | 234.46 | 0.000 |
Fat3 | Difficulties finishing things due to feeling exhausted | 2.07 | 1.49 | 306.05 | 234.26 | 0.000 |
Fat4 | Difficulties doing things under pressure of time | 2.27 | 1.57 | 219.22 | 170.91 | 0.000 |
Fat5 | Difficulties multitasking due to feeling exhausted | 2.00 | 1.43 | 304.51 | 234.61 | 0.000 |
Fat6 | Tired from reading | 1.86 | 1.41 | 274.08 | 228.4 | 0.000 |
Fat7 | Tired from watching TV | 1.79 | 1.48 | 289.96 | 251.01 | 0.002 |
Fat8 | Tired from conversation between more than two people | 1.96 | 1.54 | 286.09 | 238.79 | 0.000 |
Fat9 | Fallen asleep when reading | 1.51 | 1.48 | 253.62 | 257.66 | 0.714 |
Fat10 | Fallen asleep during a conversation | 1.08 | 1.09 | 284.11 | 283.77 | 0.956 |
Fat11 | Tiredness affecting work | 2.00 | 1.34 | 113.48 | 82.88 | 0.000 |
Fat12 | Tiredness limiting social activities | 2.06 | 1.55 | 224.71 | 171.19 | 0.000 |
Fat13 | Tiredness affecting QoL | 2.41 | 1.66 | 223.54 | 152.44 | 0.000 |
Fat14 | Worrying about feeling tired | 2.04 | 1.41 | 313.89 | 239.87 | 0.000 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU survivors | Controls | ICU survivors | Controls | |||
Phys1 | Physical health in general | 3.29 | 2.63 | 319.92 | 214.59 | 0.000 |
Phys2 | Reduced feeling in your face | 1.16 | 1.04 | 289.48 | 276.21 | 0.028 |
Phys3 | Arm weakness | 2.00 | 1.36 | 315.44 | 223.91 | 0.000 |
Phys4 | Reduced feeling in arms | 1.42 | 1.10 | 303.37 | 253.11 | 0.000 |
Phys5 | Reduced feeling in hands/fingers | 1.61 | 1.19 | 307.10 | 242.97 | 0.000 |
Phys6 | Raynaud's in fingers | 1.92 | 1.51 | 296.24 | 262.93 | 0.008 |
Phys7 | Difficulties lifting/carrying lightweight objects | 1.52 | 1.13 | 302.42 | 249.40 | 0.000 |
Phys8 | Difficulties turning on taps/opening jars | 1.66 | 1.25 | 303.28 | 244.97 | 0.000 |
Phys9 | Difficulties using your hands | 1.67 | 1.24 | 311.16 | 245.96 | 0.000 |
Phys10 | Leg weakness | 2.31 | 1.40 | 329.21 | 205.79 | 0.000 |
Phys11 | Reduced feeling in legs | 1.74 | 1.11 | 314.39 | 231.29 | 0.000 |
Phys12 | Reduced feeling in feet/toes | 1.88 | 1.18 | 315.03 | 228.25 | 0.000 |
Phys13 | Restless legs | 1.75 | 1.31 | 303.90 | 248.40 | 0.000 |
Phys14 | Dizziness when standing up | 2.10 | 1.57 | 307.51 | 241.49 | 0.000 |
Phys15 | Losing balance easily | 2.17 | 1.39 | 308.52 | 215.49 | 0.000 |
Phys16 | Difficulties climbing stairs | 2.53 | 1.32 | 314.03 | 200.02 | 0.000 |
Phys17 | Unsteady gait | 1.88 | 1.23 | 302.06 | 229.12 | 0.000 |
Phys18 | Legs feeling heavy | 1.85 | 1.19 | 311.15 | 231.48 | 0.000 |
Phys19 | Swollen legs/ankles | 2.02 | 1.36 | 309.22 | 243.61 | 0.000 |
Phys20 | Raynaud's in toes | 2.02 | 1.24 | 311.81 | 234.25 | 0.000 |
Phys21 | Contractures | 1.98 | 1.46 | 305.16 | 239.26 | 0.000 |
Phys22 | Periods of heavy sweating | 1.66 | 1.40 | 295.38 | 264.13 | 0.006 |
Phys23 | Shortness of breath limiting your physical activities | 2.29 | 1.34 | 280.41 | 191.11 | 0.000 |
Phys24 | Physically active > 30 min* | 3.03 | 3.82 | 258.46 | 342.76 | 0.000 |
Phys25 | Physical health affecting QoL | 2.82 | 1.70 | 295.22 | 172.35 | 0.000 |
Phys26 | Worrying about physical health | 2.75 | 1.86 | 318.12 | 224.90 | 0.000 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
Pain1 | Headaches | 1.85 | 1.73 | 288.44 | 281.10 | 0.585 |
Pain2 | Finding normal touch bothersome | 1.32 | 1.11 | 295.22 | 263.18 | 0.000 |
Pain3 | General body pain | 2.15 | 1.72 | 297.42 | 252.66 | 0.001 |
Pain4 | Shoulder pain | 2.29 | 1.92 | 296.63 | 263.25 | 0.014 |
Pain5 | Arm pain | 1.78 | 1.52 | 291.89 | 271.15 | 0.083 |
Pain6 | Hand pain | 1.67 | 1.40 | 294.48 | 267.39 | 0.017 |
Pain7 | Back pain | 2.57 | 2.16 | 295.79 | 264.91 | 0.027 |
Pain8 | Chest pain | 1.56 | 1.23 | 300.36 | 254.37 | 0.000 |
Pain9 | Abdominal pain | 1.74 | 1.36 | 299.65 | 254.35 | 0.000 |
Pain10 | Leg pain | 2.27 | 1.68 | 303.53 | 248.04 | 0.000 |
Pain11 | Foot pain | 2.09 | 1.48 | 304.52 | 246.06 | 0.000 |
Pain12 | Pain stopping planned activity | 2.12 | 1.46 | 309.61 | 240.04 | 0.000 |
Pain13 | Painkillers to manage ADL | 2.11 | 1.57 | 298.77 | 260.60 | 0.002 |
Pain14 | Painkillers for sufficient sleep | 1.88 | 1.32 | 302.72 | 251.32 | 0.000 |
Pain15 | Pain makes going to sleep difficult | 2.03 | 1.45 | 302.65 | 249.80 | 0.000 |
Pain16 | Woken by pain | 1.90 | 1.51 | 297.88 | 259.31 | 0.002 |
Pain17 | Pain affecting QoL | 2.74 | 1.98 | 257.81 | 182.52 | 0.000 |
Pain18 | Worrying about pain | 2.30 | 1.66 | 305.36 | 246.40 | 0.000 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
Psych1 | Crying easily | 1.83 | 1.39 | 303.02 | 256.37 | 0.000 |
Psych2 | Feeling short-tempered | 2.14 | 1.70 | 301.10 | 257.60 | 0.001 |
Psych3 | Loosing patience easily | 2.04 | 1.65 | 300.93 | 260.57 | 0.003 |
Psych4 | Difficulties feeling warmth toward family members | 1.59 | 1.39 | 290.76 | 278.08 | 0.255 |
Psych5 | Difficulties unwinding | 2.03 | 1.73 | 296.92 | 268.76 | 0.034 |
Psych6 | Worrying about little things | 2.11 | 1.75 | 298.82 | 261.93 | 0.007 |
Psych7 | Feeling low-spirited | 2.63 | 1.99 | 313.64 | 235.08 | 0.000 |
Psych8 | Feeling depressed | 2.10 | 1.54 | 309.00 | 243.00 | 0.000 |
Psych9 | Periods of anxiety | 1.87 | 1.49 | 301.12 | 260.40 | 0.001 |
Psych10 | Panic attacks | 1.33 | 1.13 | 294.38 | 263.73 | 0.000 |
Psych11 | Feelings of hopelessness | 1.99 | 1.51 | 307.93 | 240.32 | 0.000 |
Psych12 | Feelings of life being meaningless | 1.87 | 1.42 | 304.78 | 243.09 | 0.000 |
Psych13 | Cannot stop worrying about being ill | 2.10 | 1.80 | 292.98 | 265.18 | 0.039 |
Psych14 | Low self-confidence | 1.97 | 1.57 | 300.08 | 252.34 | 0.000 |
Psych15 | Low self-esteem | 1.91 | 1.58 | 296.90 | 260.03 | 0.004 |
Psych16 | Able to laugh at things* | 4.27 | 4.38 | 283.72 | 289.03 | 0.707 |
Psych17 | Able to look forward to things* | 3.93 | 4.27 | 271.09 | 308.05 | 0.009 |
Psych18 | Difficulties talking about your illness to family/close friends | 1.60 | 1.56 | 217.43 | 224.62 | 0.491 |
Psych19 | Feeling that others think you talk too much about your illness | 1.38 | 0.78 | 289.67 | 191.32 | 0.000 |
Psych20 | Mental health affecting QoL | 2.48 | 1.71 | 199.77 | 139.89 | 0.000 |
Psych21 | Worrying about psychological/mental health | 1.90 | 1.36 | 306.00 | 247.29 | 0.000 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
ADL1 | Help getting dressed | 1.43 | 1.06 | 303.30 | 266.28 | 0.000 |
ADL2 | Help moving between chair and bed | 1.27 | 1.03 | 299.95 | 273.01 | 0.000 |
ADL3 | Support sitting up | 1.14 | 1.02 | 294.51 | 280.97 | 0.007 |
ADL4 | Help visiting the toilet | 1.31 | 1.02 | 297.34 | 270.96 | 0.000 |
ADL5 | Help with shopping | 1.93 | 1.07 | 295.25 | 216.89 | 0.000 |
ADL6 | Help with cooking | 1.66 | 1.07 | 308.74 | 247.70 | 0.000 |
ADL7 | Help with housework | 2.05 | 1.09 | 321.09 | 223.33 | 0.000 |
ADL8 | Help with medication | 1.62 | 0.31 | 313.83 | 187.79 | 0.000 |
ADL9 | Avoided travelling in a car | 1.12 | 1.04 | 280.26 | 267.84 | 0.020 |
ADL10 | Avoided taking public transport | 1.41 | 1.08 | 224.63 | 200.09 | 0.000 |
ADL11 | Help managing bills | 1.63 | 1.06 | 305.80 | 253.90 | 0.000 |
ADL12 | Daily activities affecting QoL | 2.49 | 1.47 | 182.46 | 107.89 | 0.000 |
ADL13 | Worrying about daily activities | 2.08 | 1.29 | 320.40 | 228.34 | 0.000 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
Sleep1 | Need for daytime nap | 2.21 | 1.62 | 313.56 | 238.38 | 0.000 |
Sleep2 | Difficulties going to sleep | 1.98 | 1.61 | 304.12 | 258.43 | 0.001 |
Sleep3 | Need for sleeping pills | 1.91 | 1.29 | 308.91 | 250.48 | 0.000 |
Sleep4 | Anxiety before going to sleep | 1.39 | 1.10 | 300.85 | 256.46 | 0.000 |
Sleep5 | Difficulties going back to sleep | 2.04 | 1.91 | 290.62 | 284.26 | 0.641 |
Sleep6 | Night-time worrying | 1.73 | 1.61 | 289.78 | 285.93 | 0.772 |
Sleep7 | Nightmares | 1.38 | 1.17 | 301.10 | 263.29 | 0.000 |
Sleep8 | Nightly sweats disturbing sleep | 1.41 | 1.33 | 291.80 | 278.94 | 0.251 |
Sleep9 | Heart palpitations disturbing sleep | 1.18 | 1.10 | 288.00 | 276.18 | 0.138 |
Sleep10 | Sleep problems affecting QoL | 2.16 | 1.66 | 235.99 | 184.82 | 0.000 |
Sleep11 | Worrying about sleep | 1.59 | 1.39 | 295.30 | 270.40 | 0.027 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
A&A1 | Bothersome thirst | 1.78 | 1.26 | 309.00 | 252.29 | 0.000 |
A&A2 | Difficulties chewing | 1.43 | 1.08 | 302.81 | 264.77 | 0.000 |
A&A3 | Sugar cravings | 2.26 | 2.16 | 293.26 | 285.04 | 0.560 |
A&A4 | Poor appetite | 1.72 | 1.25 | 310.10 | 253.19 | 0.000 |
A&A5 | Alcohol, how often | 2.30 | 2.96 | 255.27 | 348.50 | 0.000 |
A&A6 | Alcohol, how many glasses on a typical day | 2.31 | 2.24 | 210.66 | 205.34 | 0.633 |
A&A7 | Alcohol, how often 6 or more glasses | 1.49 | 1.47 | 275.37 | 282.89 | 0.521 |
A&A8 | Appetite affecting QoL | 1.91 | 1.22 | 141.88 | 97.53 | 0.000 |
A&A9 | Worrying about your appetite | 1.34 | 1.09 | 299.26 | 264.46 | 0.000 |
A&A10 | Alcohol affecting QoL | 1.15 | 1.10 | 211.06 | 209.65 | 0.772 |
A&A11 | Worrying about alcohol | 1.14 | 1.14 | 282.87 | 292.09 | 0.203 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
Sex1 | Difficulties handling physical closeness from loved ones | 1.34 | 1.16 | 289.33 | 270.60 | 0.041 |
Sex2 | Sex drive | 3.47 | 2.82 | 299.92 | 221.88 | 0.000 |
Sex3 | Sexual activity* | 1.77 | 2.12 | 255.93 | 311.62 | 0.000 |
Sex4 | Sex life | 3.83 | 3.28 | 282.88 | 215.98 | 0.000 |
Sex5 | Orgasm* | 2.16 | 2.89 | 245.12 | 313.33 | 0.000 |
Sex6 | Bothered by being naked in front of partner | 1.39 | 1.24 | 210.11 | 198.59 | 0.152 |
Sex7 | Surgical scars affecting sex life | 1.66 | 1.14 | 172.73 | 138.35 | 0.000 |
Sex8 | Lack of energy affecting sex life | 2.06 | 1.76 | 268.63 | 241.12 | 0.025 |
Sex9 | Pain during sex | 1.23 | 1.10 | 151.17 | 139.14 | 0.026 |
Sex10 | Problems with sex life affecting QoL | 2.30 | 1.84 | 177.94 | 145.19 | 0.002 |
Sex11 | Worrying about sex life | 1.67 | 1.49 | 278.26 | 262.94 | 0.179 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
Sens1 | Reduced taste | 1.60 | 1.24 | 301.38 | 252.33 | 0.000 |
Sens2 | Reduced smell | 1.52 | 1.38 | 288.87 | 277.28 | 0.328 |
Sens3 | Sound hypersensitivity | 1.77 | 1.68 | 289.28 | 283.88 | 0.682 |
Sens4 | Difficulties hearing what people say | 1.94 | 2.06 | 278.28 | 298.40 | 0.144 |
Sens5 | Reduced hearing limiting social life | 1.36 | 1.40 | 282.41 | 287.18 | 0.656 |
Sens6 | Sound hypersensitivity limiting social life | 1.34 | 1.22 | 290.36 | 269.70 | 0.040 |
Sens7 | Tinnitus | 1.61 | 1.81 | 275.44 | 305.62 | 0.014 |
Sens8 | Mouth dryness | 1.93 | 1.35 | 311.96 | 235.31 | 0.000 |
Sens9 | Mouth soreness | 1.57 | 1.18 | 303.58 | 247.94 | 0.000 |
Sens10 | Hoarseness | 1.55 | 1.26 | 301.68 | 254.56 | 0.000 |
Sens11 | Cracking voice | 1.47 | 1.17 | 301.45 | 252.19 | 0.000 |
Sens12 | Throat pain | 1.33 | 1.14 | 294.37 | 264.87 | 0.002 |
Sens13 | Throat feeling constricted | 1.51 | 1.19 | 300.04 | 252.18 | 0.000 |
Sens14 | Choking easily | 1.42 | 1.19 | 296.30 | 259.59 | 0.000 |
Sens15 | Difficulties swallowing | 1.42 | 1.12 | 304.08 | 251.98 | 0.000 |
Sens16 | Throat problems limiting social life | 1.48 | 1.21 | 104.95 | 92.35 | 0.050 |
Sens17 | Problems from sensory organs affecting QoL | 2.10 | 1.62 | 225.93 | 171.82 | 0.000 |
Sens18 | Worrying about your sensory organs | 1.69 | 1.46 | 295.83 | 266.74 | 0.016 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
GI1 | Stoma | 1.08 | 1.02 | 295.86 | 278.45 | 0.003 |
GI2 | Constipation | 1.80 | 1.63 | 295.69 | 273.01 | 0.087 |
GI3 | Diarrhoea | 1.93 | 1.57 | 300.99 | 262.69 | 0.004 |
GI4 | Bowel urgency | 1.82 | 1.55 | 295.38 | 267.92 | 0.034 |
GI5 | Bowel leakage | 1.36 | 1.15 | 296.76 | 266.67 | 0.003 |
GI6 | Bowel problems limiting social life | 1.44 | 1.11 | 187.36 | 162.20 | 0.001 |
GI7 | Bowel problems affecting QoL | 2.12 | 1.57 | 188.55 | 146.54 | 0.000 |
GI8 | Worrying about bowel problems | 1.60 | 1.27 | 297.06 | 265.61 | 0.005 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
UT1 | Difficulties feeling the need to urinate | 1.28 | 1.06 | 294.47 | 269.54 | 0.001 |
UT2 | Difficulties emptying the bladder | 1.49 | 1.31 | 291.03 | 272.00 | 0.092 |
UT3 | Night-time emptying of bladder | 2.39 | 2.27 | 293.22 | 272.08 | 0.126 |
UT4 | Urinary urgency | 1.63 | 1.58 | 288.40 | 278.47 | 0.437 |
UT5 | Stress incontinence | 1.61 | 1.53 | 208.72 | 208.10 | 0.954 |
UT6 | Urinary problems limiting social activities | 1.34 | 1.05 | 203.27 | 180.32 | 0.000 |
UT7 | Urinary problems affecting QoL | 1.72 | 1.47 | 189.83 | 170.21 | 0.049 |
UT8 | Worrying about urinary problems | 1.48 | 1.40 | 286.82 | 287.35 | 0.962 |
Issues | Mean | Mean rank sum | p-value | |||
---|---|---|---|---|---|---|
ICU Survivors | Controls | ICU Survivors | Controls | |||
Work1 | Same type of work in 2 years' time | 2.00 | 1.69 | 148.21 | 101.97 | 0.000 |
Work2 | Capacity for work and physical demands | 3.94 | 3.21 | 268.14 | 154.45 | 0.000 |
Work3 | Capacity for work and psychological demands | 3.57 | 2.88 | 259.49 | 162.66 | 0.000 |
Work9 | Work problems affecting QoL | 3.00 | 2.63 | 107.11 | 76.60 | 0.000 |
Work10 | Financial problems affecting QoL | 3.67 | 2.74 | 116.06 | 69.81 | 0.000 |
Work11 | Worry about future working life | 2.38 | 1.94 | 240.81 | 209.20 | 0.003 |
Work12 | Worry about future work capacity | 2.42 | 2.08 | 247.13 | 200.36 | 0.000 |
Work13 | Worry about future finances | 3.15 | 2.24 | 271.78 | 213.25 | 0.000 |