Long-Term Outcomes After Bariatric Surgery: a Systematic Review and Meta-analysis of Weight Loss at 10 or More Years for All Bariatric Procedures and a Single-Centre Review of 20-Year Outcomes After Adjustable Gastric Banding
verfasst von:
Paul E. O’Brien, Annemarie Hindle, Leah Brennan, Stewart Skinner, Paul Burton, Andrew Smith, Gary Crosthwaite, Wendy Brown
Durability is a key requirement for the broad acceptance of bariatric surgery. We report on durability at and beyond 10 years with a systematic review and meta-analysis of all reports providing data at 10 or more years and a single-centre study of laparoscopic adjustable gastric banding (LAGB) with 20 years of follow-up.
Methods
Systematic review with meta-analysis was performed on all eligble reports containing 10 or more years of follow-up data on weight loss after bariatric surgery. In addition, a prospective cohort study of LAGB patients measuring weight loss and reoperation at up to 20 years is presented.
Results
Systematic review identified 57 datasets of which 33 were eligible for meta-analysis. Weighted means of the percentage of excess weight loss (%EWL) were calculated for all papers included in the systematic review. Eighteen reports of gastric bypass showed a weighted mean of 56.7%EWL, 17 reports of LAGB showed 45.9%EWL, 9 reports of biliopancreatic bypass +/− duodenal switch showed 74.1%EWL and 2 reports of sleeve gastrectomy showed 58.3%EWL. Meta-analyses of eligible studies demonstrated comparable results. Reoperations were common in all groups. At a single centre, 8378 LAGB patients were followed for up to 20 years with an overall follow-up rate of 54%. No surgical deaths occurred. Weight loss at 20 years (N = 35) was 30.1 kg, 48.9%EWL and 22.2% total weight loss (%TWL). Reoperation rate was initially high but reduced markedly with improved band and surgical and aftercare techniques.
Conclusion
All current procedures are associated with substantial and durable weight loss. More long-term data are needed for one-anastomosis gastric bypass and sleeve gastrectomy. Reoperation is likely to remain common across all procedures.
Introduction
The durability of weight loss is the key difference between medical weight loss programs and bariatric surgery [1, 2]. Many medical weight loss programs have reported substantial weight loss but almost none have reported durability beyond 2 years. The Look AHEAD study [3] has been an exception where, with major effort and high costs, a modest effect of 6% total weight loss was reported at a median follow-up of 9.6 years.
Most publications of outcomes after bariatric surgery cover the short term (1–3 years). Some cover the medium term (3–10 years) and just a few provide data on long-term weight loss (10 or more years). Effectiveness and durability are considered key attributes of bariatric surgery when compared with the non-surgical approaches to achieving weight loss. For bariatric surgery to claim a key role in obesity care, strong proof of effectiveness in the long term is needed.
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In 2013, we published a systematic review of weight loss at 10 or more years after bariatric surgery, in particular, Roux-en-Y gastric bypass (RYGB), biliopancreatic diversion with or without duodenal switch (BPD/DS) and laparoscopic adjustable gastric banding (LAGB), and we included 15-year outcome data from our patient group after LAGB [4]. That report included 23 datasets from 20 reports available in November 2011. Since that time, the number of published reports providing long-term follow-up data has more than doubled, with 57 datasets now available including some long-term data on sleeve gastrectomy. In addition, we provide very long-term follow-up (20-year) data on our experience with LAGB. To date, only two reports of very long-term data after bariatric surgery are available [5, 6]. We report the systematic review and our own data on 1 January 2018.
Materials and Methods
Systematic Review of the Literature
The present report is a synthesis of two systematic reviews. The first search was of the medical literature up to November 2011 and has been published [4]. For the present report, the literature search was extended to December 31, 2017. The pooled data are reported according to the latest Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [7].
Search Strategy
Articles were identified using the Cochrane Database, Embase, Medline Complete, PubMed, and Scopus electronic databases with the last electronic search conducted on December 31, 2017. Only published full reports were included. Search terms were developed across concepts of “bariatric surgery” ‘AND’ “longitudinal/long term/10 year”. In addition, reference lists of included articles were examined, as were three relevant systematic reviews [8‐10]. Hand searching of Obesity Surgery and Surgery for Obesity and Related Disorders was also performed.
Eligibility Criteria
Original peer-reviewed English language papers were considered for inclusion. The review considered all types of bariatric surgical procedures except for short-term temporary procedures or experimental procedures (e.g. intragastric balloon, endoscopic duodeno-jejunal bypass sleeve, intragastric stimulation). For inclusion, papers must have reported the weight loss data of at least 10 patients at ≥ 10 years after the initial surgery and expressed the weight outcome as percentage of excess weight loss (%EWL) or percentage of BMI lost (%BMIL) or had provided sufficient information to allow these values to be calculated. Although there has been a recent drive to express weight loss as % total weight loss, almost no data were available in this format. For eligible papers, the data at the final time point that met the inclusion criteria pertaining to participant numbers and weight outcome measurement are reported. We also sought to extract from eligible papers data on operation type, number of patients originally treated and the number at longest eligible follow-up, percentage patients lost to follow up, reoperation rates and weight loss outcome at maximum follow-up. Not all these data are available within the selected papers.
One reviewer conducted title and abstract screening with 10% cross-checked by a second reviewer. Both reviewers examined articles identified for full-text review and disagreements concerning inclusion were resolved by joint review. Figure 1 displays the PRISMA search process for the current review with the original review studies added.
Fig. 1
The flow diagram of the systematic review. The eligible articles from the earlier systematic review [4] are added at the level of included studies
×
Longitudinal Cohort Study
We have conducted a prospective longitudinal cohort study of all patients having LAGB as a primary bariatric procedure through the Centre for Bariatric Surgery (CBS) in Melbourne from 1994 to the present. The LAP-BAND™ (Apollo Endosurgery, Austin, TX, USA) was used in all cases. The methods of the study are detailed in the earlier report [4]. Briefly, patients treated by LAGB were entered into an electronic medical record for bariatric surgery (LapBase; LapBase Pty Ltd., Melbourne, Australia) at the initial visit. At each visit, the weight was entered. The program provided calculated values for various weight-related parameters (weight loss in kg, BMI change, % total weight loss (% TWL), % excess weight lost (% EWL)) longitudinally and as group reports. Follow-up compliance and group reports for attendance were also provided. Lost to follow up was defined as an absence from the clinic for more than 24 months. In contrast to the 15-year study [4], we did not actively seek contact with those who had not attended to achieve more complete follow-up.
Other clinical data such as reoperation/revision procedures, clinical consultation details, operation reports, endoscopy procedures, barium meals, letters and other reports were stored in LapBase as text or individual items but were not available as group reports. Thus, the details regarding reoperations are the results of hand searching of operation files and have been done for the patients of one surgeon (POB) only.
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The outcome measures that are the focus of this report include the weight loss expressed as kg lost, change in BMI, % TWL and %EWL, and reoperation/revisional surgery details. No self-reported weights are included. %EWL was defined as the loss of excess weight in kg above a BMI of 25 kg/m2 expressed as a percentage of initial weight.
Data Analysis
For the systematic review, data for all studies identified in the original and updated searches are presented. The long-term weight loss data for individual studies are summarised in the tables. In addition, weighted means were calculated to examine the long-term %EWL across each surgery technique. As %EWL was calculated from a base of BMI of 25, reports using %EBMIL were treated as equivalent to %EWL.
For studies that reported data eligible for meta-analysis, random-effects analysis was used to calculated pooled mean effect sizes with 95% confidence intervals for each operation type; LAGB (k = 13), bypass (k = 9), biliopancreatic diversion (k = 7) and gastroplasty (k = 4). Eighteen studies were excluded from the meta-analysis as they did not report a measure of variance and 2 were single reports of a procedure only. The presence of heterogeneity among effect sizes was assessed using the Q statistic and magnitude of heterogeneity with I2. Publication bias was assessed using Egger’s regression symmetry. Comprehensive meta-analysis software (version 3) was used for all analyses.
In the 20-year longitudinal study patient data for weight loss (kg), change in BMI and %EWL were summarised using descriptive statistics and expressed as means ± 95% confidence intervals (CIs). Percentage total weight loss (% TWL) is also presented.
Results
Systematic Review
The flow diagram for the search is shown in Fig. 1. The current search covering the period November 2011 to December 2017 yielded 18,304 references. After duplicates were removed, 10,853 references were screened on title and abstract, and 323 were reviewed at full text. Additional data giving separation between the fixed gastric band and the adjustable gastric band from the Swedish Obese Subjects study [11] was provided by personal communication with Dr. Lena Carlsson. Thus, 30 reports containing 34 datasets have been added to the original review which contained 20 reports and 23 datasets to provide a total of 52 reports containing 57 separate datasets for the period 1993 to December 2017. There were two randomised controlled trials [12, 13].
All studies included in the systematic review are listed in Tables 1, 2, 3 and 4 and are summarised in Table 5. There were 18 reports for gastric bypass (Table 1), 16 of which were for the Roux-en-Y (RYGB) and two were for the one anastomosis (OAGB) variant. All gastric bypass combined showed a weighted mean % EWL of 56.7% at 10 or more years with a mean of 55.4% EWL for RYGB and 80.9% EWL for OAGB. The mean EWL for the 17 reports of LAGB was 45.9% (Table 2). For the two RCTs using LAGB, the mean weight loss was 55.9% EWL. There were 11 reports of BPD ± DS which showed a mean of 74.1%EWL (table 3). For the studies of BPD (N = 4), the weighted mean was 71.5% EWL whereas for DS (N = 7), it was 75.2% EWL. Two reports of sleeve gastrectomy with a total of 79 patients (Table 4) show a mean of 57.0% EWL.
Summary of systematic review of weight loss and reoperation rates
Procedure
No. of reports
Weighted mean % EWL
Mean % EWL range
Reoperation rate range
RYGB
16
55.4
27–69
8–64%
OAGB
2
80.9
70–84
2–14%
LAGB
17
45.9
27–66
8–78%
BPD
4
71.5
64–73
NR
DS
7
75.2
61–94
3–37%
Sleeve
2
57.0
53–62
32–36%
Gastroplasty
7
50.9
− 10–62
10–40%
The single reports of fixed band and plication from Table 6 are not included
RYGB Roux-en-Y gastric bypass, OAGB one anastomosis gastric bypass, LAGB laparoscopic adjustable gastric band, BPD biliopancreatic diversion, DS duodenal switch,, , NR = not recorded
A meta-analysis was performed for those procedures where an appropriate measure of variance was provided and where more than two studies were available. The forest plots are shown in Figs. 2, 3 and 4. The pooled effect size was 60% for RYGB, 49% for LAGB and 71% for BPD ± DS. Egger’s regression was non-significant for all operation types suggesting the results are not affected by publication bias. Heterogeneity was large across all operation types [60]. Patient numbers at follow-up, assessment of heterogeneity and publication bias are shown in Table 6.
Fig. 2
Forest plot of long-term effect of RYGB on %EWL
Fig. 3
Forest plot of long-term effect of LAGB on %EWL. The RCTs were Angrisani 2013 and O’Brien 2013b
Fig. 4
Forest plot of BPD ± DS. The studies of Ballesteos-Pomar 2016 and Larrad-Jiminez 2007 were of BPD alone
Table 6
Meta-analysis pooled effect sized (%EWL), heterogeneity and publication bias
Operation
Studies (N)
Patients at follow-up
Pooled effect size (95% CI)
Q
I2 (%)
Egger’s regression intercept
RYGB
9
1326
60.05 (54.74, 65.37)
105.63*
92.43
− 3.33, p = .575
LAGB
13
485
48.84 (42.75, 54.93)
80.79*
85.15
− 1.31, p = .262
BPD/DS
7
393
71.00 (62.33, 79.67)
108.63*
94.48
− 3.33, p = .575
Gastroplasty
4
448
53.54 (45.78, 61.30)
39.01*
92.31
− 5.13, p = .492
*p < .001
×
×
×
Pooled effect sizes were compared across surgery types. BPD/DS produced significantly greater weight loss compared to all other operation types: RYGB (Q (1)=4.45, p < .05), gastroplasty (Q (1)=8.66, p < .01), LAGB (Q (1)=17.06, p < .001) and sleeve (Q (1)=4.46, p < .05). RYGB produced significantly greater weight loss compared to LAGB (Q (1)=7.62, p < .01).
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There were no differences in %EWL between RYGB and sleeve (Q (1)=.30, p = .585), sleeve and gastroplasty (Q (1)=0.29, p = .590), or between LAGB and sleeve (Q (1)=2.01, p = .156), or LAGB and gastroplasty (Q (1)=0.95, p = .330).
CBS Longitudinal Cohort Study
A total of 8378 patients (77.4% female) were treated by primary LAGB procedure. They had a mean age of 42 years (range 14–77 years) and had a mean initial weight of 121.2 kg and a mean initial BMI of 43.2 kg/m2.
Follow-up has been maintained for 54% of patients overall. The loss to follow-up was higher as the follow-up period lengthened. The percent follow-up of each annual cohort is shown in Table 6 and 7.
Table 7
Single-centre review of weight loss with up to 20 years of follow-up after LAGB
Year
No. of patients
Weight loss (kg)
95% CI
% total weight loss
Change of BMI (units)
95% CI
%EWL
95% CI
% follow-up
0
8378
0
0
0
0
1
7817
21.9
0.28
18.1
7.8
0.1
45.8
0.53
92.5
2
7264
24.6
0.34
20.4
8.8
0.12
52.6
0.62
89.1
3
6877
24.5
0.39
20.3
8.7
0.14
51.4
0.66
85.0
4
6006
24.0
0.43
19.9
8.6
0.15
49.3
0.73
69.4
5
5235
23.7
0.47
19.5
8.5
0.17
47.7
0.84
68.6
6
4570
23.2
0.50
19.2
8.3
0.18
46.4
0.93
55.0
7
3917
22.9
0.56
19.0
8.2
0.20
45.6
0.97
46.6
8
3333
23.1
0.60
19.1
8.3
0.21
45.5
1.1
43.9
9
2768
22.9
0.65
19.0
8.2
0.23
44.8
1.1
41.9
10
2275
23.2
0.73
19.4
8.3
0.25
45.5
1.3
39.0
11
1860
23.6
0.81
19.5
8.5
0.29
45.6
1.4
43.8
12
1472
24.1
0.91
20.1
8.7
0.33
46.7
1.6
36.6
13
1147
24.4
1.03
20.4
8.8
0.36
46.8
1.8
41.3
14
827
25.4
1.26
20.9
9.1
0.44
47.7
2.0
33.8
15
599
25.4
1.47
21.2
9.1
0.5
47.9
2.4
34.0
16
436
25
1.75
21.1
9.0
0.63
47.1
3.0
36.5
17
292
26.4
2.3
22.0
9.5
0.9
48.3
3.8
27.9
18
181
27.2
3.0
22.2
9.6
1.1
47.3
4.4
23.8
19
95
27.2
4.0
22.1
9.5
1.4
46.1
6.0
24.6
20
35
30.1
9.2
22.2
10.6
3.2
48.9
13.9
25.0
Mortality
There have been no deaths associated with any primary bariatric procedure or any subsequent revisional procedure. To our awareness, there have been no late deaths that should be attributed to the procedure.
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Weight Loss
The weight loss over time is shown as kg weight loss, change in BMI, % TWL and %EWL in Table 7 and as %EWL in Fig. 5. Table 7 also shows the number of patients at each annual time point. The weight loss had reached a peak at 2-year follow-up and remained relatively stable from 2 to 20 years with mean weight loss for this period of 24.8 kg representing 47.2 %EWL. Thirty-five patients have completed 20-year follow-up and have maintained a mean loss of 30.1 kg (48.9% EWL, 22.2% TWL) at that time. Nineteen of the 35 patients (54%) had retained a loss of more than 50% of their excess weight at 20 years. Although the number of patients completing 20-year follow-up is modest, much larger numbers have completed 15–19 years as shown on Table 7 and show a very similar weight loss status (Fig. 5).
Fig. 5
The weight loss expressed as %EWL ± 95% CI for the 20-year period of follow-up after LAGB. The initial N = 8378 patients. At 20 years, there was 30.1 kg weight loss and 22.2%TWL
×
Revisional Surgery
The revisional surgery rates for the 3554 patients treated by one surgeon (POB) are shown in Table 8. Enlargements of stomach above the band remain the most common indication for revision and include posterior slips, anterior slips and symmetrical enlargements. Whereas in our initial experience posterior slip was common, the shift to the pars flaccida pathway for band placement has almost totally removed that problem [61]. Anterior slip has been reduced by improved anterior fixation of the stomach across the band and symmetrical enlargement remains the main anatomical abnormality leading to revision. Of the 214 revisions after initial placement of a Lap-Band AP version, introduced in 2006, 197 procedures were for symmetrical enlargement (92%), 12 procedures for anterior slip (5.6%), and 5 procedures for posterior slip (2.3%). The need for revisional surgery for proximal enlargements has decreased markedly in the last 11 years, in association with the use of the Lap-Band AP and improved patient education, moving from more than 50% during the early era to 11.3% for the last 12-year period. Erosion of the band into the gastric lumen has occurred in 114 patients with an overall rate of 3.2%. A detailed clinical report on the first 100 erosions has been published [62]. There has been a marked reduction in this problem in association with the change of band design, decreasing from 6% during the Lap-Band 10 cm era to less than 0.7% in the Lap-Band AP era (Table 8).
Table 8
Reoperations/revisions during the follow-up period
Total period
Lap-Band 10 cm era
Lap-Band AP era
1994–2017 (N = 3554)
1994–2005 (N = 1658)
2006–2017 (N = 1896)
Enlargements
1063 (29.9%)
847 (51.7%)
214 (11.3%)
Erosions
114 (3.2%)
101 (6.1%)
13 (0.69%)
Explantations/conversion
305 (8.6%)
199 (12%)
104 (5.5%)
Port/tubing
760 (21.4%)
599 (35.7%)
161 (8.5%)
Explanations have occurred in 8.6% of patients. The most frequent reason is patient request due to food intolerance.
Port and tubing problems represent a separate and relatively minor array of events. Common problems were needle stick injury to the tubing adjacent to the port, tubing being rubbed through, breakage in the tubing generally adjacent to a metal connector and inaccessibility or rotation of the port.
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Discussion
The meta-analysis of published long-term outcomes shows the principal bariatric surgical procedures provide substantial and durable weight loss. The most impressive outcome came from the BPD or its DS variant with a pooled effect size of 71.0% EWL followed by RYGB with 60% EWL and LAGB with 49% EWL.
Data were insufficient for a meta-analysis of the sleeve gastrectomy but it generated a weighted mean of 57% EWL from the two small studies that were included in the systematic review. Similarly, OAGB had just two studies which showed a high weighted mean of 81% EWL. It is appropriate to be cautious when just two studies are available and therefore, we wait expectantly for additional long-term data on both sleeve and OAGB.
The results shown would appear to confirm the greater effectiveness and durability of bariatric surgery compared to optimal medical therapy. The Look AHEAD study which arguably provides the best example of what can be achieved by a concentrated and continuing process of an intensive lifestyle intervention, achieved approximately 15% EWL at 8 years [3].
Whilst it is reassuring to note long-term effectiveness, the quality of most of the studies was low with a general lack of control data, numerous data gaps including percentage follow-up, reoperation rates, perioperative mortality and morbidity and even the measures of variance were absent in several reports. There is a critical need for higher levels of evidence. Only two RCTs have been included [12, 13]. Angrisani et al. compared RYGB and LAGB and showed 69% EWL and 46% EWL respectively [13]. In the Australian study which compared LAGB to optimal medical therapy, the LAGB group showed 63% EWL at 10 years. More recently, three important RCTs of 5-year outcomes with RYGB versus sleeve gastrectomy have been published [63‐65]. The SLEEVEPASS study [63] reported 57% EWL for RYGB and 49% EWL for sleeve at 5 years. The SM_BOSS study [64] reported 68% excess BMI lost (EBMIL) for RYGB and 61% EBMIL for sleeve. The STAMPEDE study [65] reported 21.7% TWL for RYGB and 18.5% TWL for sleeve. We look forward to longer follow-up from these and other such studies. It is likely that the broad acceptance of bariatric surgery will not occur until these additional higher quality data become available.
The CBS longitudinal cohort study shows substantial weight loss to be present by 2 years and this effect remained relatively constant for the subsequent 18 years, finishing with a final value of 48.9% EWL and 22.2% TWL at 20 years (N = 35). Only one other study has reported longer follow-up. Gunther et al. [5] followed 198 patients for up to 25 years. For transected RYGB patients, they reported 29.9% EWL at 20 years (N = 53) and 25.5% EWL at 25 years (N = 62) [5]. They reported a net weight gain at 25 years for their gastroplasty patients. The adjustability of the LAGB could be a key factor in maintaining stable weight loss status compared to the progressive fading of effect with non-adjustable stapling procedures.
Revisional surgery was not always reported in the studies within the systematic review but, when provided, showed reoperation was common after all surgical options. The need for reoperation has been seen to be a weakness of LAGB and the reoperation rate for the longitudinal cohort study was high during the Lap-Band 10 cm era with over 50% needing revision for proximal gastric enlargements above the band. The need dropped sharply during the Lap-Band AP era to just over 10%. Part of this lower incidence would reflect lead-time bias. Other factors include an improved band design and better understanding of how the band works [66‐68] leading to more appropriate patient education and aftercare support.
In the review of our 15-year outcomes [4], we had provided a table identifying important modifications of the band, its placement and aftercare up to 2012 that were leading to improved outcomes. Two recent additions to that list are worth noting. The first is the use of the mesh fixation of the access port. This technique has added several advantages of less post-operative pain, easier adjustments of the band in the office and less reoperation for needle stick injury or unstable port position. As a consequence, attendance at aftercare is better, leading to improved outcomes. The second important change has been a better focus on slow eating with the strict adherence to a minimum of 1-min duration between bites [68]. This has enabled better control of appetite and reduced incidence of symmetrical enlargement.
The systematic review has shown that all procedures have a substantial need for re-operative surgery and the levels of reoperation for LAGB during the Lap-Band AP at CBS are within the range of other bariatric procedures in the systematic review.
Maintaining completeness of follow-up will always be a major challenge for long-term follow-up studies. Direct contact follow-up was available in the CBS study of 58% overall. This is less than 81% follow up achieved in the 15-year follow-up report [4], in which study we made dedicated effort to bring in as many additional patients as possible. No specific efforts were made for the present study. The 58% achieved for the full 20-year cohort can be compared to the 57% direct contact follow-up achieved at 7 years for the LABS-2 study [69, 70], a well-funded and strongly committed clinical trial.
The studies have several limitations. The quality of the data for the systematic review was low with only two randomised controlled trial available. A total of 18 reports accepted for the systematic review had to be excluded from the meta-analysis because they provided no appropriate measure of variance. The secondary aims of the systematic review could not always be achieved as data on mortality, percentage patients lost to follow up and reoperation rates were not provided in many cases. The relative lack of long-term data for sleeve gastrectomy is of concern as it has already become the most common bariatric procedure [71], yet lacking strong evidence of durability. Notably, the 5-year weight loss from one of the RCTs using the sleeve [63] is the same as our data on the 20-year weight loss for LAGB.
In summary, RYGB, LAGB and BPD/DS lead to substantial weight loss which continues for at least 10 years. Each has an effect size three to four times that of optimal non-surgical therapy. The reoperation rate is significant for each procedure. Long-term data on sleeve gastrectomy and OAGB are modest at this time. Data on LAGB from a single centre shows stability of weight loss at just less than 50% EWL through 20 years. There has been a substantial reduction in reoperation rates associated with improved band design and better quality of patient education due to with improved understanding of how the band works. Guidance to the obese patient should balance durable effectiveness with risks, costs, health benefits and effect on quality of life.
Compliance with Ethical Standards
Ethical approval to perform the study was provided by The Avenue Hospital Human Research Ethics committee in accordance with the guidelines of the National Health and Medical Research Council and the Helsinki Declaration of 1964 and its later amendments.
Conflict of Interest
Dr. O’Brien reports grants from Allergan Inc., grants from Apollo Endosurgery and grants from Applied Medical during the conduct of the study.
Dr. Brown reports grants from Johnson and Johnson, grants from Medtronic, grants from GORE, personal fees from GORE, grants from Applied Medical, grants from Apollo Endosurgery, grants and personal fees from Novo Nordisc and personal fees from Merck Sharpe and Dohme.
There were no other reported conflicts of interest.
Informed Consent
Informed consent was not applicable or required for this study.
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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Long-Term Outcomes After Bariatric Surgery: a Systematic Review and Meta-analysis of Weight Loss at 10 or More Years for All Bariatric Procedures and a Single-Centre Review of 20-Year Outcomes After Adjustable Gastric Banding
verfasst von
Paul E. O’Brien Annemarie Hindle Leah Brennan Stewart Skinner Paul Burton Andrew Smith Gary Crosthwaite Wendy Brown
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Dr. med. Mihailo Andric Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
