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09.07.2018 | Original Article

Long-Term Outcomes in Patients with Anemia And Cerebral Venous Thrombosis

verfasst von: Kai Liu, Bo Song, Yuan Gao, Lu Zhao, Hui Fang, Yunchao Wang, Lulu Pei, Kaihao Han, Shen Li, Yusheng Li, Yuming Xu

Erschienen in: Neurocritical Care | Ausgabe 3/2018

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Abstract

Background

Anemia is associated with unfavorable functional outcome in ischemic and hemorrhagic stroke. However, the relationship between anemia and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.

Methods

Consecutive CVT patients were retrospectively identified from November 2011, through January 2017. Anemia was defined according to the World Health Organization criteria (non-pregnant female hemoglobin level < 120 g/L, pregnant female < 110 g/L and male < 130 g/L), which was further classified as mild, moderate, and severe anemia according to hemoglobin concentration, and as microcytic, normocytic, and macrocytic anemia according to mean corpuscular volume. Unfavorable outcome was defined as modified Rankin Scale (mRS) of 3–6. Factors such as age, sex, coma, malignancy, intracerebral hemorrhage, and straight sinus and/or deep CVT involved, premorbid mRS were adjusted to evaluate the relationship between anemia and prognosis in CVT patients.

Results

A total of 238 CVT patients were included, among whom 73 patients (30.67%) were diagnosed with anemia. Multivariate logistic regression analysis showed that patients with anemia had a higher risk of mRS of 3–6 (OR = 3.62; 95% CI, 1.45–9.01; P = 0.006) and mortality (OR = 5.46; 95% CI, 1.90–15.70; P = 0.002). Subgroup analysis showed that severe anemia was independently associated with mRS of 3–6 (OR = 8.80; 95% CI, 1.90–40.81; P = 0.005) and mortality (OR = 9.82; 95% CI, 1.81–53.25; P = 0.010). Similarly, microcytic anemia increased the risk of mRS of 3–6 (OR = 4.64; 95% CI, 1.48–14.52; P = 0.008) and mortality (OR = 9.68; 95% CI, 2.61–35.91; P = 0.001). In addition, our study also revealed that lower hemoglobin level, evaluated as a continuous variable, was inversely associated with mRS of 3–6 (OR = 0.98; 95% CI, 0.96–0.99; P = 0.007) and mortality (OR = 0.97; 95% CI, 0.95–0.99; P = 0.005).

Conclusions

Anemia was a significant and independent predictor of unfavorable functional outcome in patients with CVT.

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Titel: Long-Term Outcomes in Patients with Anemia And Cerebral Venous Thrombosis
verfasst von: Kai Liu
Bo Song
Yuan Gao
Lu Zhao
Hui Fang
Yunchao Wang
Lulu Pei
Kaihao Han
Shen Li
Yusheng Li
Yuming Xu
Publikationsdatum: 09.07.2018
Verlag: Springer US
Erschienen in: Neurocritical Care / Ausgabe 3/2018
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-018-0544-6

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Long-Term Outcomes in Patients with Anemia And Cerebral Venous Thrombosis

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Background

Methods

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