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Erschienen in: Annals of Hematology 1/2021

08.10.2020 | Original Article

Long-term outcomes of 172 children with severe aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine

verfasst von: Yang Lan, Lixian Chang, Meihui Yi, Yuli Cai, Jing Feng, Yuanyuan Ren, Chao Liu, Xiaoyan Chen, Shuchun Wang, Ye Guo, Aoli Zhang, Lipeng Liu, Jingliao Zhang, Xiaofan Zhu

Erschienen in: Annals of Hematology | Ausgabe 1/2021

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Abstract

This study retrospectively analyzed the clinical outcome of 172 children with newly diagnosed severe aplastic anemia (SAA) between January 2008 and April 2018, who received rabbit antithymocyte globulin (ATG) and cyclosporine (CsA) as first-line treatment. The median age at diagnosis was 5 years (range, 1–14). The overall response rates were 22.7%, 45.3%, and 61% at 40 days, 3 months, and 6 months, respectively, after rabbit ATG. In multivariate analysis, mild disease severity was the only predictor of favorable response at 6 months (P = 0.006). In the present study, median follow-up period was 63 months (range, 1–135). The 5-year overall survival (OS) and failure-free survival (FFS) rates were 90.5% and 70.4%. Multivariate analysis showed that erythroid burst-forming units (BFU-E) > 2/105 bone marrow mononuclear cell (BMMNC) (P = 0.037) and time interval before IST ≤ 30 days (P = 0.017) were independent positive predictors for OS, meanwhile BFU-E > 2/105BMMNC (P = 0.029) was the only favorable prognostic factor for FFS.
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Metadaten
Titel
Long-term outcomes of 172 children with severe aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine
verfasst von
Yang Lan
Lixian Chang
Meihui Yi
Yuli Cai
Jing Feng
Yuanyuan Ren
Chao Liu
Xiaoyan Chen
Shuchun Wang
Ye Guo
Aoli Zhang
Lipeng Liu
Jingliao Zhang
Xiaofan Zhu
Publikationsdatum
08.10.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Annals of Hematology / Ausgabe 1/2021
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-020-04296-9

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