Long-term outcomes of central neurocytoma – an institutional experience
- 12.06.2024
- Case Study
Erschienen in:
- Verfasst von
- Yufan Yang
- Nitin Wadhwani
- Aoi Shimomura
- Shuhua Zheng
- James Chandler
- Maciej S. Lesniak
- Matthew C. Tate
- Adam M. Sonabend
- John Kalapurakal
- Craig Horbinski
- Rimas Lukas
- Roger Stupp
- Priya Kumthekar
- Sean Sachdev
- Erschienen in
- Journal of Neuro-Oncology | Ausgabe 1/2024
Abstract
Introduction
Central Neurocytoma (CN) is a rare, WHO grade 2 brain tumor that predominantly affects young adults. Gross total resection (GTR) is often curative for CNs, but the optimal treatment paradigm including incorporation of RT, following subtotal resection (STR) and for scarcer pediatric cases has yet to be established.
Methods
Patients between 2001 and 2021 with a pathologic diagnosis of CN were reviewed. Demographic, treatment, and tumor characteristics were recorded. Recurrence free survival (RFS) and overall survival (OS) were calculated according to the Kaplan Meier-method. Post-RT tumor volumetric regression analysis was performed.
Results
Seventeen adults (≥ 18 years old) and 5 children (< 18 years old) met the criteria for data analysis (n = 22). With a median follow-up of 6.9 years, there was no tumor-related mortality. Patients who received STR and/or had atypical tumors (using a cut-off of Ki-67 > 4%) experienced decreased RFS compared to those who received GTR and/or were without atypical tumors. RFS at 5 years for typical CNs was 67% compared to 22% for atypical CNs. Every pediatric tumor was atypical and 3/5 recurred within 5 years. Salvage RT following tumor recurrence led to no further recurrences within the timeframe of continued follow-up; volumetric analysis for 3 recurrent tumors revealed an approximately 80% reduction in tumor size.
Conclusion
We provide encouraging evidence that CNs treated with GTR or with RT after tumor recurrence demonstrate good long-term tumor control.
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- Titel
- Long-term outcomes of central neurocytoma – an institutional experience
- Verfasst von
-
Yufan Yang
Nitin Wadhwani
Aoi Shimomura
Shuhua Zheng
James Chandler
Maciej S. Lesniak
Matthew C. Tate
Adam M. Sonabend
John Kalapurakal
Craig Horbinski
Rimas Lukas
Roger Stupp
Priya Kumthekar
Sean Sachdev
- Publikationsdatum
- 12.06.2024
- Verlag
- Springer US
- Erschienen in
-
Journal of Neuro-Oncology / Ausgabe 1/2024
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373 - DOI
- https://doi.org/10.1007/s11060-024-04713-3
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