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International Journal of Colorectal Disease

Erschienen in:

03.01.2019 | Original Article

Long-term prognosis after treatment for T1 carcinoma of laterally spreading tumors: a multicenter retrospective study

verfasst von: Ken Yamashita, Shiro Oka, Shinji Tanaka, Shinji Nagata, Toshio Kuwai, Akira Furudoi, Tadamasa Tamura, Masaki Kunihiro, Hideharu Okanobu, Koichi Nakadoi, Hiroyuki Kanao, Makoto Higashiyama, Koji Arihiro, Kazuya Kuraoka, Fumio Shimamoto, Kazuaki Chayama

Erschienen in: International Journal of Colorectal Disease | Ausgabe 3/2019

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Abstract

Purpose

Long-term prognosis of T1 laterally spreading tumors (LSTs) after treatment have not been clarified. This study compared clinicopathological characteristics and long-term prognosis of T1 LSTs.

Methods

We retrospectively assessed 169 patients with 169 T1 LSTs between January 1992 and December 2008 by ten hospitals. Patients who did not meet the Japanese Society for Cancer of the Colon and Rectum (JSCCR) 2016 guidelines for the treatment of colorectal carcinoma (CRC) criteria were defined as non-endoscopically curable. The number of non-endoscopically curable patients with LST-granular/ nodular mixed (LST-G-M) was 61, that with LST-non-granular/ flat elevated (LST-NG-FE) was 23, and that with LST-non-granular/ pseudo depressed (LST-NG-PD) was 23. Clinicopathological variables and long-term prognosis were analyzed.

Results

For overall patients, tumor size, number of non-endoscopically curable cases, and rate of submucosal invasion depth ≥ 1000 μm for the LST-G-M group were significantly higher than those in the other groups. For non-endoscopically curable patients, the tumor size for those with LST-G-M was significantly larger than those in the other groups. The rate of submucosal invasion width ≥ 4000 μm and type B/C muscularis mucosae with LST-G-M was higher than that with LST-NG-FE. All recurrences occurred in non-endoscopically curable patients with LST-G-M. Five-year overall and disease-free survivals for non-endoscopically curable patients with LST-G-M were significantly shorter than those for patients with non-endoscopically curable LST-NG-FE and PD.

Conclusions

Our data supported adequacy of the JSCCR guidelines for the treatment of CRC criteria for endoscopically curable patients after T1 LSTs treatment. Patients with T1 LST-G-M should be followed up more carefully.

Kudo S (1993) Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy 25:455–461CrossRefPubMed

Kudo S, Lambert R, Allen JI, Fujii H, Fujii T, Kashida H, Matsuda T, Mori M, Saito H, Shimoda T, Tanaka S, Watanabe H, Sung JJ, Feld AD, Inadomi JM, O'Brien MJ, Lieberman DA, Ransohoff DF, Soetikno RM, Triadafilopoulos G, Zauber A, Teixeira CR, Rey JF, Jaramillo E, Rubio CA, Van Gossum A, Jung M, Vieth M, Jass JR, Hurlstone PD (2008) Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc 68:S3–S47CrossRefPubMed

Oka S, Tanaka S, Kanao H, Oba S, Chayama K (2009) Therapeutic strategy for colorectal laterally spreading tumor. Dig Endosc 21:S43–S46CrossRefPubMed

Xu MD, Wang XY, Li QL, Zhou PH, Zhang YQ, Zhong YS, Chen WF, Ma LL, Qin WZ, Hu JW, Yao LQ (2013) Colorectal lateral spreading tumor subtypes: clinicopathology and outcome of endoscopic submucosal dissection. Int J Color Dis 28:63–72CrossRef

Saito Y, Fujii T, Kondo H, Mukai H, Yokota T, Kozu T, Kozu T, Saito D (2001) Endoscopic treatment for laterally spreading tumors in the colon. Endoscopy 33:682–686CrossRefPubMed

Shigita K, Oka S, Tanaka S, Sumimoto K, Hirano D, Tamaru Y, Tamaru Y, Ninomiya Y, Asayama N, Hayashi N, Nagata S, Arihiro K, Chayama K (2016) Clinical significance and validity of the subclassification for colorectal laterally spreading tumor granular type. J Gastroenterol Hepatol 31:973–979CrossRefPubMed

Nishiyama H, Isomoto H, Yamaguchi N, Ishii H, Fukuda E, Machida H, Machida H, Nakamura T, Ohnita K, Shikuwa S, Kohno S, Nakao K (2010) Endoscopic submucosal dissection for laterally spreading tumors of the colorectum in 200 consecutive cases. Surg Endosc 24:2881–2887CrossRefPubMed

Kim BC, Chang HJ, Han KS, Sohn DK, Hong CW, Park JW, Park JW, Park SC, Choi HS, Oh JH (2011) Clinicopathological difference of laterally spreading tumors of the colorectum according to gross appearance. Endoscopy 43:100–107CrossRefPubMed

Rotondao G, Bianco MA, Buffoli F, Gizzi G, Tessari F, Cipolletta L (2011) The Cooperative Italian FLIN Study Group: prevalence and clinico-pathological features of colorectal laterally spreading tumors. Endoscopy 43:856–861CrossRef

10.

Lee YJ, Kim ES, Park KS, Cho KB, Lee MY, Kim SK, Kim SK, Jeon SW, Jung MK, Jang BI, Kim KO, Lee SH, Kim EY, Kwon JG, Jung JT, Yang CH, Kim WJ, Kim HJ, Seo HE (2014) Inter-observer agreement in the endoscopic classification of colorectal laterally spreading tumors: a multicenter study between experts and trainees. Dig Dis Sci 59:2550–2556CrossRefPubMed

11.

Zhao X, Zhan Q, Xiang L, Wang Y, Wang X, Li A, Liu S (2014) Clinicopathological characteristics of laterally spreading colorectal tumor. PLoS One 9:e94552CrossRefPubMedPubMedCentral

12.

Myung DS, Kweon SS, Lee J, Shin IS, Kim SW, Seo GS, Kim HS, Joo YE (2017) Clinicopathological features of laterally spreading colorectal tumors and their association with advanced histology and invasiveness: an experience from Honam province of South Korea: a Honam Association for the Study of Intestinal Diseases (HASID). PLoS One 12:e0184205CrossRefPubMedPubMedCentral

13.

Cong ZJ, Hu LH, Ji JT, Xing JJ, Shan YQ, Li ZS, Yu ED (2016) A long-term follow-up on the prognosis of endoscopic submucosal dissection for colorectal laterally spreading tumors. Gastrointest Endosc 83:800–807CrossRefPubMed

14.

Yamada M, Saito Y, Sakamoto T, Nakajima T, Kushima R, Parra-Blanco A, Matsuda T (2016) Endoscopic predictors of deep submucosal invasion in colorectal laterally spreading tumors. Endoscopy 48:456–464CrossRefPubMed

15.

Matsuda T, Marugame T, Kamo K, Katanoda K, Ajiki W, Sobue T (2012) Cancer incidence and incidence rates in Japan in 2006: based on data from 15 population-based cancer registries in the monitoring of cancer incidence in Japan (MCIJ) project. Jpn J Clin Oncol 42:139–147CrossRefPubMed

16.

Shigita K, Oka S, Tanaka S, Sumimoto K, Hirano D, Tamaru Y, Ninomiya Y, Asayama N, Hayashi N, Shimamoto F, Arihiro K, Chayama K (2017) Long-term outcomes after endoscopic submucosal dissection for superficial colorectal tumors. Gastrointest Endosc 85:546–553CrossRefPubMed

17.

Boda K, Oka S, Tanaka S, Nagata S, Kunihiro M, Kuwai T, Hiraga Y, Furudoi A, Terasaki M, Nakadoi K, Higashiyama M, Okanobu H, Akagi M, Chayama K (2018) Clinical outcome of endoscopic submucosal dissection for colorectal tumors. Gastrointest Endosc 87:714–722CrossRefPubMed

18.

Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, Saito Y, Hamaguchi T, Ishida H, Ishiguro M, Ishihara S, Kanemitsu Y, Kawano H, Kinugasa Y, Kokudo N, Murofushi K, Nakajima T, Oka S, Sakai Y, Tsuji A, Uehara K, Ueno H, Yamazaki K, Yoshida M, Yoshino T, Boku N, Fujimori T, Itabashi M, Koinuma N, Morita T, Nishimura G, Sakata Y, Shimada Y, Takahashi K, Tanaka S, Tsuruta O, Yamaguchi T, Yamaguchi N, Tanaka T, Kotake K, Sugihara K (2018) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23:1–34CrossRefPubMed

19.

Asayama N, Oka S, Tanaka S, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Egi H, Hinoi T, Ohdan H, Arihiro K, Chayama K (2016) Long-term outcomes after treatment for T1 colorectal carcinoma. Int J Color Dis 31:571–578CrossRef

20.

Tamaru Y, Oka S, Tanaka S, Nagata S, Hiraga Y, Kuwai T, Furudoi A, Tamura T, Kunihiro M, Okanobu H, Nakadoi K, Kanao H, Higashiyama M, Arihiro K, Kuraoka K, Shimamoto F, Chayama K (2017) Long-term outcomes after treatment for T1 colorectal carcinoma: a multicenter retrospective cohort study of Hiroshima GI Endoscopy Research Group. J Gastroenterol 52:1169–1179CrossRefPubMed

21.

Yoshii S, Nojima M, Nosho K, Omori S, Kusumi T, Okuda H, Tsukagoshi H, Fujita M, Yamamoto H, Hosokawa M (2014) Factors associated with risk for colorectal cancer recurrence after endoscopic resection of T1 tumors. Clin Gastroenterol Hepatol 12(2):292–302CrossRefPubMed

22.

Ikematsu H, Yoda Y, Matsuda T, Yamaguchi Y, Hotta K, Kobayashi N, Fujii T, Oono Y, Sakamoto T, Nakajima T, Takao M, Shinohara T, Murakami Y, Fujimori T, Kaneko K, Saito Y (2013) Long-term outcomes after resection for submucosal invasive colorectal cancers. Gastroenterology 144:551–559CrossRefPubMed

23.

Yoda Y, Ikematsu H, Matsuda T, Yamaguchi Y, Hotta K, Kobayashi N, Fujii T, Oono Y, Sakamoto T, Nakajima T, Takao M, Shinohara T, Fujimori T, Kaneko K, Saito Y (2013) A large-scale multicenter study of long-term outcomes after endoscopic resection for submucosal invasive colorectal cancer. Endoscopy 45:718–724CrossRefPubMed

24.

Belderbos TD, van Erning FN, de Hingh IH, van Oijen MG, Lemmens VE, Siersema PD (2017) Long-term recurrence-free survival after standard endoscopic resection versus surgical resection of submucosal invasive colorectal cancer: a population-based study. Clin Gastroenterol Hepatol 15:403–411CrossRefPubMed

25.

Oka S, Tanaka S, Saito Y, Iishi H, Kudo SE, Ikematsu H, Igarashi M, Saitoh Y, Inoue Y, Kobayashi K, Hisabe T, Tsuruta O, Sano Y, Yamano H, Shimizu S, Yahagi N, Watanabe T, Nakamura H, Fujii T, Ishikawa H, Sugihara K (2015) Local recurrence after endoscopic resection for large colorectal neoplasia: a multicenter prospective study in Japan. Am J Gastroenterol 110:697–707CrossRefPubMed

26.

Nakadoi K, Oka S, Tanaka S, Hayashi N, Terasaki M, Arihiro K, Shimamoto F, Chayama K (2014) Condition of muscularis mucosae is a risk factor for lymph node metastasis in T1 colorectal carcinoma. Surg Endosc 28:1269–1276CrossRefPubMed

27.

Ueno H, Mochizuki H, Hashiguchi Y, Shimazaki H, Aida S, Hase K, Matsukuma S, Kanai T, Kurihara H, Ozawa K, Yoshimura K, Bekku S (2004) Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology 127:385–394CrossRefPubMed

28.

Tanaka S, Haruma K, Teixeira CR, Tatsuta S, Ohtsu N, Hiraga Y, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F (1995) Endoscopic treatment of submucosal invasive colorectal carcinoma with special reference. J Gastroenterol 30:710–717CrossRefPubMed

29.

Tanaka S, Haruma K, Oh-E H, Nagata S, Hirota Y, Furudoi AT, Kitadai Y, Yoshihara M, Shimamoto F (2000) Conditions of curability after endoscopic resection for colorectal carcinoma with submucosally massive invasion. Oncol Rep 7:783–788PubMed

30.

Ueno H, Hase K, Hashiguchi Y, Shimazaki H, Yoshii S, Kudo SE, Tanaka M, Akagi Y, Suto T, Nagata S, Matsuda K, Komori K, Yoshimatsu K, Tomita Y, Yokoyama S, Shinto E, Nakamura T, Sugihara K (2014) Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review. J Gastroenterol 49:1314–1323CrossRefPubMed

31.

Miyamoto H, Ikematsu H, Fujii S, Osera S, Odagaki T, Oono Y, Yano T, Ochiai A, Sasaki Y, Kaneko K (2014) Clinicopathological differences of laterally spreading tumors arising in the colon and rectum. Int J Color Dis 29:1069–1075CrossRef

32.

Uraoka T, Saito Y, Matsuda T, Ikehara H, Gotoda T, Saito D, Fujii T (2006) Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut 55:1592–1597CrossRefPubMedPubMedCentral

33.

Burgess NG, Hourigan LF, Zanati SA, Brown GJ, Singh R, Williams SJ, Raftopoulos SC, Ormonde D, Moss A, Byth K, Mahajan H, McLeod D, Bourke MJ (2017) Risk stratification for covert invasive cancer among patients referred for colonic endoscopic mucosal resection: a large multicenter cohort. Gastroenterology 153:732–742CrossRefPubMed

34.

Goto SP, Sakamoto N, Mitomi H, Murakami T, Ritsuno H, Ueyama H, Matsumoto K, Shibuya T, Osada T, Nagahara A, Ogihara T, Yao T, Watanabe S (2014) Histological distinction between the granular and nongranular types of laterally spreading tumors of the colorectum. Gastroenterol Res Pract ID153935. https://doi.org/10.1155/2014/153935

35.

Toh EW, Brown P, Morris E, Botterill I, Quirke P (2015) Area of submucosal invasion and width of invasion predicts lymph node metastasis in pT1 colorectal cancers. Dis Colon Rectum 58:393–400CrossRefPubMed

36.

Smith KJ, Jones PF, Burke DA, Treanor D, Finan PJ, Quirke P (2011) Lymphatic distribution in the mucosa and submucosa and potential implications of T1 colorectal tumors. Dis Colon Rectum 54:35–40CrossRefPubMed

37.

Asayama N, Oka S, Tanaka S, Hayashi N, Arihiro K, Chayama K (2015) Endoscopic submucosal dissection as total excisional biopsy for clinical T1 colorectal carcinoma. Digestion 91:64–69CrossRefPubMed

38.

Kobayashi H, Mochizuki H, Morita T, Kotake K, Teramoto T, Kameoka S, Saito Y, Takahashi K, Hase K, Oya M, Maeda K, Hirai T, Kameyama M, Shirouzu K, Sugihara K (2011) Characteristics of recurrence after curative resection for T1 colorectal cancer: Japanese multicenter study. J Gastroenterol 46:203–211CrossRefPubMed

Titel: Long-term prognosis after treatment for T1 carcinoma of laterally spreading tumors: a multicenter retrospective study
verfasst von: Ken Yamashita
Shiro Oka
Shinji Tanaka
Shinji Nagata
Toshio Kuwai
Akira Furudoi
Tadamasa Tamura
Masaki Kunihiro
Hideharu Okanobu
Koichi Nakadoi
Hiroyuki Kanao
Makoto Higashiyama
Koji Arihiro
Kazuya Kuraoka
Fumio Shimamoto
Kazuaki Chayama
Publikationsdatum: 03.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Colorectal Disease / Ausgabe 3/2019
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-018-3203-7

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Long-term prognosis after treatment for T1 carcinoma of laterally spreading tumors: a multicenter retrospective study