Long-Term Survival with Chemoradiation Alone in Locally Advanced Unresectable Gallbladder Cancer: First Case Report of a New Paradigm

Excerpt

Gallbladder cancer (GBC) is endemic in North India in the Indo-Gangetic belt and usually presents as unresectable or metastatic disease [1]. Palliative chemotherapy is the only treatment which yields a median survival of 9 months [2]. Unresectable GBCs are those which are involving the portal vein, hepatic artery, or contiguous organs and those with distant nodal disease or metastases. Attempt at neoadjuvant strategies in non-metastatic locally advanced gallbladder cancer shows resectability rates ranging from 15–40% [3, 4]. Survival beyond 25 months has not been reported with this strategy. We report the first case with 8-year-survival after chemoradiation in a woman with locally advanced gallbladder cancer. …