03.10.2016 | Clinical Investigation | Ausgabe 1/2017

Longitudinal change in choroidal thickness after trabeculectomy in primary open-angle glaucoma patients

Zeitschrift:: Japanese Journal of Ophthalmology > Ausgabe 1/2017

Autoren:: Munemitsu Yoshikawa, Tadamichi Akagi, Hideo Nakanishi, Hanako Ohashi Ikeda, Satoshi Morooka, Hiroshi Yamada, Tomoko Hasegawa, Yuto Iida, Nagahisa Yoshimura

Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.1007/s10384-016-0482-9) contains supplementary material, which is available to authorized users.

Abstract

Purpose

To investigate longitudinal changes in intraocular pressure (IOP), axial length (AL), and choroidal thickness (ChT) in primary open-angle glaucoma (POAG) eyes after trabeculectomy and to evaluate the parameters that might influence those changes.

Methods

In this prospective observational study, we recruited 28 patients with POAG (28 eyes) scheduled for trabeculectomy. The average macular ChTs and foveal retinal thicknesses along 6-mm segments centered on the fovea were examined preoperatively and postoperatively (at 1, 3, and 6 months) using swept-source optical coherence tomography. The IOP, AL, and mean deviation (MD) of standard automated perimetry (SAP) were also analyzed as independent variables.

Results

Results from 16 patients were included in the final analysis. A significant increase in ChT with respect to the preoperative value was observed at every postoperative stage (1 month, P < 0.001; 3 months, P < 0.001; 6 months, P = 0.011), whereas the retinal thickness showed no significant change over the study period. The ChT increase and IOP reduction were sustained throughout the 6-month period without further significant changes. Stepwise multivariate analyses showed significant correlations between the percentage decrease in IOP and the percentage increase in ChT at 1 and 6 months postoperatively. The percentage increase in ChT was also significantly correlated with a better MD of the SAP at 1 month (β = 0.01; P = 0.009).

Conclusions

The ChT increase following trabeculectomy was sustained at 1, 3, and 6 months postoperatively. The percentage increase in ChT was significantly correlated with the percentage change in IOP and (more weakly) with better SAP MD values.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Jetzt einloggen Kostenlos registrieren

★ PREMIUM-INHALT

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der Fachzeitschriften, inklusive eines Print-Abos.

Jetzt gratis testen * Jetzt kaufen

Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Supplementary Fig. 1 Scatterplots of 3 independent variables: choroidal thickness (ChT), age, and axial length (AL). (a) In our dataset, the older patients had shorter ALs (ρ = -0.745, P < 0.001; Spearman rank correlation). (b) In the univariate analysis, age and ChT were not significantly associated (ρ = -0.019, P = 0.94), probably because of the confounding bias between age and AL. (c) The patients with longer ALs tended to have thinner ChTs (ρ = -0.541, P = 0.030) (TIFF 101 kb)

10384_2016_482_MOESM1_ESM.tif

Supplementary Fig. 2 Scatterplots of the percentage decrease in intraocular pressure (IOP) against the percentage increase in choroidal thickness (ChT) at the postoperative 1-month (a), 3-month (b), and 6-month (c) stages. In the univariate analysis, the percentage increase in ChT was not significantly associated with the percentage decrease in IOP, as shown in Table 4 (TIFF 101 kb)

Tham Y-C, Li X, Wong TY, Quigley HA, Aung T, Cheng C-Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121:2081–90. CrossRefPubMed

The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol. 2000;130:429–40. CrossRef

Musch DC, Gillespie BW, Lichter PR, Niziol LM, Janz NK. Visual field progression in the Collaborative Initial Glaucoma Treatment Study: the impact of treatment and other baseline factors. Ophthalmology. 2009;116:200–7. CrossRefPubMed

Fannin LA, Schiffman JC, Budenz DL. Risk factors for hypotony maculopathy. Ophthalmology. 2003;110:1185–91. CrossRefPubMed

Rulli E, Biagioli E, Riva I, Gambirasio G, De Simone I, Floriani I, et al. Efficacy and safety of trabeculectomy vs nonpenetrating surgical procedures: a systematic review and meta-analysis. JAMA Ophthalmol. 2013;131:1573–82. CrossRefPubMed

Stamper RL, McMenemy MG, Lieberman MF. Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil. Am J Ophthalmol. 1992;114:544–53. CrossRefPubMed

Reis ASC, O’Leary N, Stanfield MJ, Shuba LM, Nicolela MT, Chauhan BC. Laminar displacement and prelaminar tissue thickness change after glaucoma surgery imaged with optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:5819–26. CrossRefPubMed

Yoshikawa M, Akagi T, Hangai M, Ohashi-Ikeda H, Takayama K, Morooka S, et al. Alterations in the neural and connective tissue components of glaucomatous cupping after glaucoma surgery using swept-source optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55:477–84. CrossRefPubMed

Lee EJ, Kim TW, Weinreb RN. Reversal of lamina cribrosa displacement and thickness after trabeculectomy in glaucoma. Ophthalmology. 2012;119:1359–66. CrossRefPubMed

10.

Usui S, Ikuno Y, Uematsu S, Morimoto Y, Yasuno Y, Otori Y. Changes in axial length and choroidal thickness after intraocular pressure reduction resulting from trabeculectomy. Clin Ophthalmol. 2013;7:1155–61. CrossRefPubMedPubMedCentral

11.

Saeedi O, Pillar A, Jefferys J, Arora K, Friedman D, Quigley H. Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy. Br J Ophthalmol. 2014;98:976–9. CrossRefPubMed

12.

Kara N, Baz O, Altan C, Satana B, Kurt T, Demirok A. Changes in choroidal thickness, axial length, and ocular perfusion pressure accompanying successful glaucoma filtration surgery. Eye (Lond). 2013;27:940–5. CrossRef

13.

Agoumi Y, Sharpe GP, Hutchison DM, Nicolela MT, Artes PH, Chauhan BC. Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls. Ophthalmology. 2011;118:52–9. CrossRefPubMed

14.

Hata M, Hirose F, Oishi A, Hirami Y, Kurimoto Y. Changes in choroidal thickness and optical axial length accompanying intraocular pressure increase. Jpn J Ophthalmol. 2012;56:564–8. CrossRefPubMed

15.

Marcus MW, de Vries MM, Junoy Montolio FG, Jansonius NM. Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. Ophthalmology. 2011;118(1989–94):e2.

16.

Lopilly-Park HY, Jeon SH, Park CK. Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma. Ophthalmology. 2012;119:10–20. CrossRef

17.

Inoue R, Hangai M, Kotera Y, Nakanishi H, Mori S, Morishita S, et al. Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma. Ophthalmology. 2009;116:214–22. CrossRefPubMed

18.

Lee EJ, Kim TW, Kim M, Kim H. Influence of lamina cribrosa thickness and depth on the rate of progressive retinal nerve fiber layer thinning. Ophthalmology. 2015;122:721–9. CrossRefPubMed

19.

Maul EA, Friedman DS, Chang DS, Boland MV, Ramulu PY, Jampel HD, et al. Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients. Ophthalmology. 2011;118:1571–9. CrossRefPubMedPubMedCentral

20.

Mwanza JC, Hochberg JT, Banitt MR, Feuer WJ, Budenz DL. Lack of association between glaucoma and macular choroidal thickness measured with enhanced depth-imaging optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52:3430–5. CrossRefPubMedPubMedCentral

21.

Mwanza JC, Sayyad FE, Budenz DL. Choroidal thickness in unilateral advanced glaucoma. Invest Ophthalmol Vis Sci. 2012;53:6695–701. CrossRefPubMed

22.

Rhew JY, Kim YT, Choi KR. Measurement of subfoveal choroidal thickness in normal-tension glaucoma in Korean patients. J Glaucoma. 2014;23:46–9. CrossRefPubMed

23.

Wang W, Zhang X. Choroidal thickness and primary open-angle glaucoma: a cross-sectional study and meta-analysis. Invest Ophthalmol Vis Sci. 2014;55:6007–14. CrossRefPubMed

24.

Zhang Z, Yu M, Wang F, Dai Y, Wu Z. Choroidal thickness and open-angle glaucoma: a meta-analysis and systematic review. J Glaucoma. 2016;25:e446–54. CrossRefPubMed

25.

Jonas JB, Steinmetz P, Forster TM, Schlichtenbrede FC, Harder BC. Choroidal thickness in open-angle glaucoma. J Glaucoma. 2015;24:619–23. CrossRefPubMed

26.

Ehrlich JR, Peterson J, Parlitsis G, Kay KY, Kiss S, Radcliffe NM. Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography. Exp Eye Res. 2011;92:189–94. CrossRefPubMed

27.

Li L, Bian A, Zhou Q, Mao J. Peripapillary choroidal thickness in both eyes of glaucoma patients with unilateral visual field loss. Am J Ophthalmol. 2013;156(1277–84):e1. CrossRef

28.

Hirooka K, Tenkumo K, Fujiwara A, Baba T, Sato S, Shiraga F. Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma. BMC Ophthalmol. 2012;12:29. CrossRefPubMedPubMedCentral

29.

Park HY, Lee NY, Shin HY, Park CK. Analysis of macular and peripapillary choroidal thickness in glaucoma patients by enhanced depth imaging optical coherence tomography. J Glaucoma. 2014;23:225–31. PubMed

30.

Roberts KF, Artes PH, O’Leary N, Reis ASC, Sharpe GP, Hutchison DM, et al. Peripapillary choroidal thickness in healthy controls and patients with focal, diffuse, and sclerotic glaucomatous optic disc damage. Arch Ophthalmol. 2012;130:980–6. CrossRefPubMed

31.

Sigler EJ, Mascarenhas KG, Tsai JC, Loewen NA. Clinicopathologic correlation of disc and peripapillary region using SD-OCT. Optom Vis Sci. 2013;90:84–93. CrossRefPubMedPubMedCentral

32.

Usui S, Ikuno Y, Miki A, Matsushita K, Yasuno Y, Nishida K. Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma. Am J Ophthalmol. 2012;153(10–6):e1.

33.

Yamada H, Akagi T, Nakanishi H, Ikeda HO, Kimura Y, Suda K, et al. Microstructure of peripapillary atrophy and subsequent visual field progression in treated primary open-angle glaucoma. Ophthalmology. 2016;123:542–51. CrossRefPubMed

34.

Kim YW, Lee EJ, Kim TW, Kim M, Kim H. Microstructure of β-zone parapapillary atrophy and rate of retinal nerve fiber layer thinning in primary open-angle glaucoma. Ophthalmology. 2014;121:1341–9. CrossRefPubMed

35.

Lee EJ, Kim TW. Lamina cribrosa reversal after trabeculectomy and the rate of progressive retinal nerve fiber layer thinning. Ophthalmology. 2015;122:2234–42. CrossRefPubMed

36.

Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, et al. Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52:4971–8. CrossRefPubMed

37.

Akagi T, Hangai M, Kimura Y, Ikeda HO, Nonaka A, Matsumoto A, et al. Peripapillary scleral deformation and retinal nerve fiber damage in high myopia assessed with swept-source optical coherence tomography. Am J Ophthalmol. 2013;155:927–36. CrossRefPubMed

38.

Fleiss JL. The design and analysis of clinical experiments. Hoboken: Wiley; 1999. doi: 10.1002/9781118032923. CrossRef

39.

Wei WB, Xu L, Jonas JB, Shao L, Du KF, Wang S, et al. Subfoveal choroidal thickness: the Beijing Eye Study. Ophthalmology. 2013;120:175–80. CrossRefPubMed

40.

Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29:144–68. CrossRefPubMed

41.

Riva CE, Titze P, Hero M, Petrig BL. Effect of acute decreases of perfusion pressure on choroidal blood flow in humans. Invest Ophthalmol Vis Sci. 1997;38:1752–60. PubMed

42.

Delaey C, Van de Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res. 2000;32:249–56. CrossRefPubMed

43.

Noda Y, Ogawa A, Toyama T, Ueta T. Long-term increase in subfoveal choroidal thickness after surgery for senile cataracts. Am J Ophthalmol. 2014;158(455–9):e1.

44.

Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology. 2008;115:85–93. CrossRefPubMed

45.

Schmidl D, Garhofer G, Schmetterer L. The complex interaction between ocular perfusion pressure and ocular blood flow—relevance for glaucoma. Exp Eye Res. 2011;93:141–55. CrossRefPubMed

46.

Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–93. CrossRefPubMed

47.

Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology. 2007;114:1965–72. CrossRefPubMed

48.

Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Hypertension, perfusion pressure, and primary open-angle glaucoma: a population-based assessment. Arch Ophthalmol. 1995;113:216–21. CrossRefPubMed

49.

Usui S, Ikuno Y, Akiba M, Maruko I, Sekiryu T, Nishida K, et al. Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects. Invest Ophthalmol Vis Sci. 2012;53:2300–7. CrossRefPubMed

50.

Saito M, Kano M, Itagaki K, Ise S, Imaizumi K, Sekiryu T. Subfoveal choroidal thickness in polypoidal choroidal vasculopathy after switching to intravitreal aflibercept injection. Jpn J Ophthalmol. 2016;60:35–41. CrossRefPubMed

51.

Lee TG, Yu SY, Kwak HW. Variations in choroidal thickness after high-dose systemic corticosteroid treatment in children with chronic glomerulonephritis. Retina. 2015;35:2567–73. CrossRefPubMed

52.

Hashimoto Y, Saito W, Saito M, Hirooka K, Mori S, Noda K, et al. Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy. Jpn J Ophthalmol. 2015;59:252–60. CrossRefPubMed

Titel: Longitudinal change in choroidal thickness after trabeculectomy in primary open-angle glaucoma patients
Autoren:: Munemitsu Yoshikawa
Tadamichi Akagi
Hideo Nakanishi
Hanako Ohashi Ikeda
Satoshi Morooka
Hiroshi Yamada
Tomoko Hasegawa
Yuto Iida
Nagahisa Yoshimura
Publikationsdatum: 03.10.2016
DOI: https://doi.org/10.1007/s10384-016-0482-9
Verlag: Springer Japan
Zeitschrift: Japanese Journal of Ophthalmology The Official International Journal of the Japanese Ophthalmological Society
Ausgabe 1/2017
Print ISSN: 0021-5155
Elektronische ISSN: 1613-2246

Neu im Fachgebiet Augenheilkunde

15.06.2018 | Video plus | Ausgabe 7/2018

Longitudinal change in choroidal thickness after trabeculectomy in primary open-angle glaucoma patients

Electronic supplementary material

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Diakaustische Kammerwinkeluntersuchung

Das Kind in der Kunst

Telematik und telemedizinische Leistungen unter rechtsophthalmologischen Aspekten

Frühgeborenenretinopathie in welchem Stadium wie behandeln?

Springer Medizin

Electronic supplementary material

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Effect of leaking perifoveal microaneurysms on resolution of diabetic macular edema treated by combination therapy using anti-vascular endothelial growth factor and short pulse focal/grid laser photocoagulation

Comparison between ranibizumab and aflibercept for macular edema associated with central retinal vein occlusion

Eyelid cleansing with ointment for obstructive meibomian gland dysfunction

The effect of the extent of the incision in the Schlemm canal on the surgical outcomes of suture trabeculotomy for open-angle glaucoma

Laser flare-cell photometer: principle and significance in clinical and basic ophthalmology

Wound stability and surgically induced corneal astigmatism after transconjunctival single-plane sclerocorneal incision cataract surgery

Neu im Fachgebiet Augenheilkunde

Diakaustische Kammerwinkeluntersuchung

Das Kind in der Kunst

Telematik und telemedizinische Leistungen unter rechtsophthalmologischen Aspekten

Frühgeborenenretinopathie in welchem Stadium wie behandeln?