Background
Methods
Study design and cohort
Lung function assessment
Measurement of covariates
Ascertainment of the studied outcomes
Data analysis
Results
Baseline characteristics of the study population
Decline in FEV1 and the studied outcomes
Studied outcomes | Model | Q1 | Q2 | Q3 | Q4 |
---|---|---|---|---|---|
FEV1 decline | |||||
Cardiovascular events | Non-adjusted | 1.95 (1.74, 2.19) | 2.42 (2.16, 2.71) | 1.67 (1.48, 1.88) | Reference |
Adjusted | 1.33 (1.19, 1.49) | 1.30 (1.16, 1.46) | 1.07 (0.95, 1.21) | Reference | |
Coronary heart disease | Non-adjusted | 2.05 (1.72, 2.44) | 2.05 (1.71, 2.45) | 1.67 (1.39, 2.00) | Reference |
Adjusted | 1.38 (1.16, 1.65) | 1.08 (0.90, 1.29) | 1.04 (0.86, 1.26) | Reference | |
Chronic heart failure | Non-adjusted | 2.02 (1.72, 2.36) | 2.53 (2.17, 2.96) | 1.98 (1.69, 2.33) | Reference |
Adjusted | 1.47 (1.25, 1.73) | 1.39 (1.19, 1.63) | 1.33 (1.13, 1.56) | Reference | |
Stroke | Non-adjusted | 1.94 (1.60, 2.36) | 2.49 (2.06, 3.01) | 1.65 (1.35, 2.02) | Reference |
Adjusted | 1.35 (1.11, 1.64) | 1.34 (1.10, 1.62) | 1.08 (0.88, 1.33) | Reference | |
FVC decline | |||||
Cardiovascular events | Non-adjusted | 2.72 (2.43, 3.04) | 2.21 (1.97, 2.47) | 1.47 (1.31, 1.66) | Reference |
Adjusted | 1.28 (1.14, 1.44) | 1.15 (1.02, 1.30) | 1.06 (0.94, 1.20) | Reference | |
Coronary heart disease | Non-adjusted | 2.89 (2.41, 3.46) | 2.42 (2.01, 2.90) | 1.74 (1.44, 2.10) | Reference |
Adjusted | 1.45 (1.20, 1.75) | 1.33 (1.10, 1.61) | 1.25 (1.03, 1.51) | Reference | |
Chronic heart failure | Non-adjusted | 3.22 (2.77, 3.75) | 2.45 (2.10, 2.86) | 1.43 (1.21, 1.69) | Reference |
Adjusted | 1.35 (1.15, 1.58) | 1.21 (1.03, 1.42) | 1.03 (0.87, 1.22) | Reference | |
Stroke | Non-adjusted | 2.67 (2.22, 3.22) | 2.23 (1.85, 2.69) | 1.25 (1.02, 1.53) | Reference |
Adjusted | 1.28 (1.06, 1.56) | 1.19 (0.98, 1.45) | 0.94 (0.77, 1.16) | Reference |
Decline in FVC and the studied outcomes
Dose-response relationship and Kaplan-Meier survival analysis
Stratification and sensitivity analysis
Q1 | Q2 | Q3 | Q4 | P for interaction | |
---|---|---|---|---|---|
FEV1 decline | |||||
Age, years | |||||
< 60 | 1.36 (1.10, 1.67) | 1.25 (1.01, 1.56) | 0.86 (0.68, 1.08) | Reference | < 0.001 |
≥ 60 | 1.23 (1.07, 1.42) | 1.24 (1.08, 1.43) | 1.12 (0.97, 1.30) | Reference | |
Sex | |||||
Women | 1.20 (1.03, 1.41) | 1.21 (1.04, 1.40) | 0.98 (0.84, 1.14) | Reference | 0.50 |
Men | 1.49 (1.25, 1.77) | 1.41 (1.18, 1.70) | 1.17 (0.97, 1.42) | Reference | |
Race | |||||
Non-white | 1.61 (1.21, 2.14) | 1.07 (0.74, 1.54) | 1.21 (0.86, 1.71) | Reference | 0.95 |
White | 1.30 (1.14, 1.47) | 1.32 (1.17, 1.50) | 1.06 (0.93, 1.21) | Reference | |
Baseline BMI | |||||
Normal | 1.34 (1.11, 1.63) | 1.14 (0.94, 1.38) | 1.03 (0.84, 1.26) | Reference | 0.85 |
Overweight | 1.25 (1.04, 1.51) | 1.37 (1.14, 1.65) | 1.03 (0.85, 1.25) | Reference | |
Obese | 1.39 (1.10, 1.75) | 1.37 (1.08, 1.74) | 1.19 (0.93, 1.53) | Reference | |
Smoking status | |||||
Never | 1.23 (1.02, 1.47) | 1.19 (1.00, 1.42) | 0.98 (0.81, 1.18) | Reference | 0.33 |
Former | 1.69 (1.29, 2.20) | 1.65 (1.28, 2.12) | 1.33 (1.03, 1.71) | Reference | |
Current | 1.28 (1.06, 1.54) | 1.24 (1.01, 1.52) | 1.00 (0.80, 1.24) | Reference | |
FVC decline | |||||
Age, years | |||||
< 60 | 1.64 (1.31, 2.05) | 1.34 (1.08, 1.67) | 1.18 (0.96, 1.46) | Reference | < 0.001 |
≥ 60 | 1.13 (0.98, 1.30) | 1.03 (0.90, 1.19) | 0.98 (0.84, 1.14) | Reference | |
Sex | |||||
Women | 1.25 (1.07, 1.47) | 1.09 (0.94, 1.28) | 1.01 (0.86, 1.18) | Reference | 0.50 |
Men | 1.32 (1.10, 1.58) | 1.22 (1.01, 1.46) | 1.09 (0.90, 1.31) | Reference | |
Race | |||||
Non-white | 1.51 (1.10, 2.08) | 1.15 (0.79, 1.67) | 1.02 (0.70, 1.48) | Reference | 0.95 |
White | 1.26 (1.11, 1.43) | 1.16 (1.03, 1.32) | 1.06 (0.93, 1.21) | Reference | |
Baseline BMI | |||||
Normal | 1.28 (1.06, 1.56) | 1.10 (0.91, 1.33) | 1.08 (0.89, 1.31) | Reference | 0.85 |
Overweight | 1.16 (0.96, 1.39) | 1.02 (0.84, 1.23) | 0.96 (0.79, 1.17) | Reference | |
Obese | 1.40 (1.09, 1.79) | 1.50 (1.16, 1.93) | 1.17 (0.90, 1.51) | Reference | |
Smoking status | |||||
Never | 1.28 (1.06, 1.54) | 1.20 (1.00, 1.44) | 1.25 (1.04, 1.51) | Reference | 0.33 |
Former | 1.24 (0.94, 1.63) | 1.15 (0.87, 1.53) | 1.01 (0.75, 1.36) | Reference | |
Current | 1.36 (1.13, 1.63) | 1.10 (0.90, 1.34) | 0.87 (0.73, 1.08) | Reference |