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Erschienen in: Journal of General Internal Medicine 14/2022

07.02.2022 | Original Research

Longitudinal Study of Analgesic Use and Risk of Incident Persistent Tinnitus

verfasst von: MD, ScM Sharon G. Curhan, MD, MPH Jordan Glicksman, PhD Molin Wang, MD, SM Roland D. Eavey, MD, ScD Gary C. Curhan

Erschienen in: Journal of General Internal Medicine | Ausgabe 14/2022

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Abstract

Background

Persistent tinnitus is common, disabling, and difficult to treat. High-dose aspirin may precipitate tinnitus, but longitudinal data on typical dose aspirin and other analgesics are scarce.

Objective

To investigate independent associations of aspirin, NSAIDs, and acetaminophen and risk of incident persistent tinnitus.

Design

Longitudinal cohort study.

Setting

Nurses’ Health Study II (1995–2017).

Participants

A total of 69,455 women, age 31–48 years, without tinnitus at baseline.

Main Measures

Information on analgesic use and tinnitus obtained by biennial questionnaires.

Key Results

After 1,120,936 person-years of follow-up, 10,452 cases of incident persistent tinnitus were reported. For low-dose aspirin, the risk of developing persistent tinnitus was not elevated among frequent low-dose aspirin users. For moderate dose aspirin, frequent use was associated with higher risk of tinnitus among women aged < 60 years, but not among older women (p-interactionage = 0.003). Compared with women aged < 60 using moderate-dose aspirin < 1 day/week, the multivariable-adjusted hazard ratio (MVHR, 95% CI) among women using moderate-dose aspirin 6–7 days per week was 1.16 (1.03, 1.32). Among all women, frequent non-aspirin non-steroidal anti-inflammatory drug (NSAID) or acetaminophen use was associated with higher risk. Compared with women using NSAIDs <1 day/week, the MVHR for use 4–5days/week was 1.17 (1.08, 1.28) and for 6–7days/week was 1.07 (1.00, 1.16) (p-trend=0.001). For acetaminophen, compared with use <1 day/week, the MVHR for use 6–7days/week was 1.18 (1.07, 1.29) (p-trend=0.002).

Limitations

Information on tinnitus and analgesic use was self-reported. Information on indications for analgesic use was not available. Studies in non-White women and men are needed.

Conclusion

The risk of developing persistent tinnitus was not elevated among frequent low-dose aspirin users. Among younger women, frequent moderate-dose aspirin use was associated with higher risk. Frequent NSAID use and frequent acetaminophen use were associated with higher risk of incident persistent tinnitus among all women, and the magnitude of the risks tended to be greater with increasing frequency of use. Our results suggest analgesic users are at higher risk for developing tinnitus and may provide insight into the precipitants of this challenging disorder, but additional investigation to determine whether there is a causal association is needed.
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Metadaten
Titel
Longitudinal Study of Analgesic Use and Risk of Incident Persistent Tinnitus
verfasst von
MD, ScM Sharon G. Curhan
MD, MPH Jordan Glicksman
PhD Molin Wang
MD, SM Roland D. Eavey
MD, ScD Gary C. Curhan
Publikationsdatum
07.02.2022
Verlag
Springer International Publishing
Erschienen in
Journal of General Internal Medicine / Ausgabe 14/2022
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-021-07349-5

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