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Erschienen in: Indian Journal of Hematology and Blood Transfusion 1/2021

21.09.2020 | Images

Loss of Normal Polyploid Spectrum as Marker of Clonality in Acute Megakaryoblastic Leukemia Evolving from Pre-Existing Primary Myelofibrosis

verfasst von: Nishit Gupta, Aditi Mittal, Tina Dadu, Anil Handoo

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Ausgabe 1/2021

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Excerpt

Normal megakaryocytes are polyploid cells with DNA content ranging from tetraploid to 128 N and originate from the diploid (2 N) promegakaryoblasts following endomitosis. Acute megakaryoblastic Leukemia (AML-M7) is characterized by differentiation blockade at the promegakaryoblast stage and induction of terminal polyploidy can be a potential therapeutic approach [1]. …
Literatur
1.
Zurück zum Zitat Mazzi S, Lordier L, Debili N, Raslova H, Vainchenker W (2018) Megakaryocyte and polyploidization. Exp Hematol 57:1–3CrossRef Mazzi S, Lordier L, Debili N, Raslova H, Vainchenker W (2018) Megakaryocyte and polyploidization. Exp Hematol 57:1–3CrossRef
2.
Zurück zum Zitat Feng G, Gale RP, Cui W, Cai W, Huang G, Xu Z et al (2015) A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes. Experimental Hematol Oncol 5(1):12CrossRef Feng G, Gale RP, Cui W, Cai W, Huang G, Xu Z et al (2015) A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes. Experimental Hematol Oncol 5(1):12CrossRef
Metadaten
Titel
Loss of Normal Polyploid Spectrum as Marker of Clonality in Acute Megakaryoblastic Leukemia Evolving from Pre-Existing Primary Myelofibrosis
verfasst von
Nishit Gupta
Aditi Mittal
Tina Dadu
Anil Handoo
Publikationsdatum
21.09.2020
Verlag
Springer India
Erschienen in
Indian Journal of Hematology and Blood Transfusion / Ausgabe 1/2021
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-020-01355-z

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