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27.02.2019 | Original Article

Loss of Regulatory Immune Function in Coronary Artery Disease Patients from the Indian Population

Zeitschrift:
Journal of Cardiovascular Translational Research
Autoren:
Thiruvelselvan Ponnusamy, Srikanth Komarulu Venkatachala, Manjunatha Ramanujappa, Lakshmi Mundkur
Wichtige Hinweise
Associate Editor Angela Taylor oversaw the review of this article

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12265-019-09872-7) contains supplementary material, which is available to authorized users.

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Abstract

The pathogenic roles of inflammatory T cells and monocytes subsets have not been explored in different manifestations of coronary artery disease. We studied the frequency of these cells, their response to autoantigens, regulatory cell functional assay, foam cell formation and macrophage differentiation in 181 patients (stable angina, ST-elevated myocardial infarction (STEMI), NSTEMI, and unstable angina), and 34 controls and in samples collected during recurrent cardiac events and from patients showing clinical improvement. The proportion of Th17 cells and monocytes gradually increased in patients with stable angina at one end of the spectrum followed by NSTEMI, STEMI, and unstable angina at other end. Inflammatory cells were positively and inversely associated with recurrent events and clinical improvement, respectively. Patients showed expansion of Th17 cells in response to autoantigen (HSP60) and compromised Treg function. Our results suggest that stress-induced activation of inflammatory cells expands in the absence of regulatory control in CAD patients.

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12265_2019_9872_MOESM1_ESM.pdf
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