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Journal of Cardiovascular Translational Research

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27.02.2019 | Original Article

Loss of Regulatory Immune Function in Coronary Artery Disease Patients from the Indian Population

verfasst von: Thiruvelselvan Ponnusamy, Srikanth Komarulu Venkatachala, Manjunatha Ramanujappa, Lakshmi Mundkur

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 4/2019

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Abstract

The pathogenic roles of inflammatory T cells and monocytes subsets have not been explored in different manifestations of coronary artery disease. We studied the frequency of these cells, their response to autoantigens, regulatory cell functional assay, foam cell formation and macrophage differentiation in 181 patients (stable angina, ST-elevated myocardial infarction (STEMI), NSTEMI, and unstable angina), and 34 controls and in samples collected during recurrent cardiac events and from patients showing clinical improvement. The proportion of Th17 cells and monocytes gradually increased in patients with stable angina at one end of the spectrum followed by NSTEMI, STEMI, and unstable angina at other end. Inflammatory cells were positively and inversely associated with recurrent events and clinical improvement, respectively. Patients showed expansion of Th17 cells in response to autoantigen (HSP60) and compromised Treg function. Our results suggest that stress-induced activation of inflammatory cells expands in the absence of regulatory control in CAD patients.

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Titel: Loss of Regulatory Immune Function in Coronary Artery Disease Patients from the Indian Population
verfasst von: Thiruvelselvan Ponnusamy
Srikanth Komarulu Venkatachala
Manjunatha Ramanujappa
Lakshmi Mundkur
Publikationsdatum: 27.02.2019
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 4/2019
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-019-09872-7

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Loss of Regulatory Immune Function in Coronary Artery Disease Patients from the Indian Population

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