The online version of this article (doi:10.1186/1477-7819-10-190) contains supplementary material, which is available to authorized users.
The authors have no conflicts of interest or financial ties to disclose.
HHL and CHP were involved in the conception and design of the study, carried out data analysis, and drafted the manuscript. CHL, JMP and YKC were responsible for acquisition and interpretation of data.KYS, and HMJ were responsible for interpretation of data and CHP, KYS and HMJ carried out critical revision of the manuscript. All authors have read and approved the final manuscript.
The accuracy of endoscopic ultrasonography (EUS) for preoperative staging of gastric cancer varies. The aim of this study was to investigate the accuracy of EUS tumor (T) and node (N) staging, and to identify the histopathological factors influencing accuracy based on the detailed tumor depth of gastric cancer.
In total, 309 patients with gastric cancer with confirmed pathological staging underwent EUS examination for preoperative staging at Seoul St. Mary’s Hospital, Korea, between January and December 2009. The T and N staging of EUS and the pathologic report were compared.
The overall accuracies of EUS for T stage and the detailed T stages were 70.2% and 43.0%, respectively. In detailed stage, tumors greater than 50 mm in diameter were significantly associated with T overstaging (odds ratio (OR) = 2.094). The overall accuracy of EUS for N staging was 71.2%. Tumor size (20 mm ≤ size < 50 mm, OR = 4.389; and 50 mm ≤ size, OR = 8.170), cross-sectional tumor location (circumferential, OR = 4.381) and tumor depth (submucosa, OR = 3.324; muscular propria, OR = 6.923; sub-serosa, OR = 4.517; and serosa-exposed, OR = 6.495) were significant factors affecting incorrect nodal detection.
Careful attention is required during EUS examination of large-sized gastric cancers to increase accuracy, especially for T staging.
Neugut AI, Hayek M, Howe G: Epidemiology of gastric cancer. Semin Oncol. 1996, 23: 281-291. PubMed
Caletti G, Ferrari A, Brocchi E, Barbara L: Accuracy of endoscopic ultrasonography in the diagnosis and staging of gastric cancer and lymphoma. Surgery. 1993, 113: 14-27. PubMed
Bhandari S, Shim CS, Kim JH, Jung IS, Cho JY, Lee JS, Lee MS, Kim BS: Usefulness of three-dimensional, multidetector row CT (virtual gastroscopy and multiplanar reconstruction) in the evaluation of gastric cancer: a comparison with conventional endoscopy, EUS, and histopathology. Gastrointest Endosc. 2004, 59: 619-626. 10.1016/S0016-5107(04)00169-5. CrossRefPubMed
Xi WD, Zhao C, Ren GS: Endoscopic ultrasonography in preoperative staging of gastric cancer: determination of tumor invasion depth, nodal involvement and surgical resectability. World J Gastroenterol. 2003, 9: 254-257. PubMed
Tseng LJ, Mo LR, Tio TL, Fresner YT, Jao N, Lin RC, Kuo JY, Chang KK, Wang CH, Wey KC: Video-endoscopic ultrasonography in staging gastric carcinoma. Hepatogastroenterology. 2000, 47: 897-900. PubMed
Massari M, Cioffi U, De Simone M, Bonavina L, D'Elia A, Rosso L, Ferro C, Montorsi M: Endoscopic ultrasonography for preoperative staging of gastric carcinoma. Hepatogastroenterology. 1996, 43: 542-546. PubMed
Smith JW, Brennan MF, Botet JF, Gerdes H, Lightdale CJ: Preoperative endoscopic ultrasound can predict the risk of recurrence after operation for gastric carcinoma. J Clin Oncol. 1993, 11: 2380-2385. PubMed
- Low accuracy of endoscopic ultrasonography for detailed T staging in gastric cancer
Han Hong Lee
Chul Hyun Lim
Jae Myung Park
Yu Kyung Cho
Kyo Young Song
Hae Myung Jeon
Cho Hyun Park
- BioMed Central
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