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Erschienen in: Clinical and Experimental Nephrology 12/2019

07.09.2019 | Original article

Low birth weight is associated with decline in renal function in Japanese male and female adolescents

verfasst von: Ayano Murai-Takeda, Takeshi Kanda, Tatsuhiko Azegami, Hiroshi Hirose, Mikako Inokuchi, Hirobumi Tokuyama, Shu Wakino, Mitsuaki Tokumura, Hiroshi Kawabe, Masaaki Mori, Hiroshi Itoh

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 12/2019

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Abstract

Background

Low birth weight (LBW) is a risk factor for chronic kidney disease (CKD) in later life and is becoming increasingly common in developed countries, including Japan. Furthermore, a serial decrease in birth weight has been associated with an increasing prevalence of CKD stage 2 in male Japanese adolescents. Sex-specific differences affect CKD susceptibility, and the association between birth weight and CKD in women, has not been elucidated. In this study, we investigated the sex-specific effect of LBW on renal function.

Methods

Annual cross-sectional data of 2417 Japanese adolescents (males 1736; females 681), aged 15–16 years, were evaluated over 8 years (2007–2014).

Results

Over the study period, mean birth weights decreased significantly in males (p < 0.01) and females (p < 0.05). Furthermore, both sexes showed significant decrease in estimated glomerular filtration rates corresponding to the birth weight reduction. The prevalence of CKD stage 2 also increased in males (from 26.0 to 32.4%, p < 0.01) and females (from 6.3 to 18.5%, p < 0.05). The incidence of CKD stage 2 was significantly related to history of LBW (males: odds ratio 1.73; 95% confidence interval 1.06–2.80; p < 0.05; females: odds ratio 3.29; 95% confidence interval 1.25–8.02; p < 0.05).

Conclusions

Our data revealed that renal function and birth weight have decreased over time, in healthy Japanese adolescents. In view of the recent declining trend demonstrated by birth weight in Japan, we speculate that the prevalence of CKD might increase in the future.
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Metadaten
Titel
Low birth weight is associated with decline in renal function in Japanese male and female adolescents
verfasst von
Ayano Murai-Takeda
Takeshi Kanda
Tatsuhiko Azegami
Hiroshi Hirose
Mikako Inokuchi
Hirobumi Tokuyama
Shu Wakino
Mitsuaki Tokumura
Hiroshi Kawabe
Masaaki Mori
Hiroshi Itoh
Publikationsdatum
07.09.2019
Verlag
Springer Singapore
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 12/2019
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-019-01784-9

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