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High Blood Pressure & Cardiovascular Prevention
Erschienen in:

01.06.2019 | Review article

Low Density Lipoprotein (LDL) Cholesterol as a Causal Role for Atherosclerotic Disease: Potential Role of PCSK9 Inhibitors

verfasst von: Rita Del Pinto, Davide Grassi, Giuliana Properzi, Giovambattista Desideri, Claudio Ferri

Erschienen in: High Blood Pressure & Cardiovascular Prevention | Ausgabe 3/2019

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Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9)-related discoveries of the turn of the century have translated into substantial novelty in dyslipidemia treatment in the last 5 years. With chronic preventable atherosclerotic cardiovascular diseases (ASCVD) representing an epidemic of morbidity and mortality worldwide, low-density lipoprotein cholesterol (LDL-c) reduction represents a public health priority. By overcoming two major statin-related issues, namely intolerance and ineffectiveness, PCSK9 inhibitors have offered a safe and effective option in selected clinical settings where LDL-c reduction is required. Herein, we recapitulate recent findings, clinical applications, and ASCVD prevention potential of PCSK9 inhibition, with focus on anti-PCSK9 monoclonal antibodies, evolocumab and alirocumab.
Fußnoten
1
Consistent with guidelines, documented clinical ASCVD includes previous acute myocardial infarction, acute coronary syndrome (ACS), coronary revascularization and other arterial revascularization procedures, stroke and transient ischaemic attack, aortic aneurysm, and peripheral arterial disease. Unequivocally documented ASCVD on imaging includes plaque on coronary angiography or carotid ultrasound. It does not include some increase in continuous imaging parameters such as intima–media thickness of the carotid artery.
 
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Metadaten
Titel
Low Density Lipoprotein (LDL) Cholesterol as a Causal Role for Atherosclerotic Disease: Potential Role of PCSK9 Inhibitors
verfasst von
Rita Del Pinto
Davide Grassi
Giuliana Properzi
Giovambattista Desideri
Claudio Ferri
Publikationsdatum
01.06.2019
Verlag
Springer International Publishing
Erschienen in
High Blood Pressure & Cardiovascular Prevention / Ausgabe 3/2019
Print ISSN: 1120-9879
Elektronische ISSN: 1179-1985
DOI
https://doi.org/10.1007/s40292-019-00323-7

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