Skip to main content
Erschienen in: Lasers in Medical Science 6/2020

11.03.2020 | Review Article

Low-level laser therapy and narrative review of other treatment modalities in androgenetic alopecia

verfasst von: Hassan Galadari, Swathi Shivakumar, Torello Lotti, Uwe Wollina, Andy Goren, Ghasem Rahmatpour Rokni, Stephan Grabbe, Mohamad Goldust

Erschienen in: Lasers in Medical Science | Ausgabe 6/2020

Einloggen, um Zugang zu erhalten

Abstract

Androgenetic alopecia (AGA), also termed as androgenic alopecia or common baldness, is a condition where there is androgen mediated conversion of susceptible terminal hair into vellus hair. Although it is reported more commonly in males, it also affects females but the incidence is relatively unknown. AGA tremendously affects the psychology of the patient due to its chronicity of treatment and cosmetic implications. There are numerous treatment options available for AGA but the choice of treatment has to often be tailored according to the patient’s needs, affordability, and compliance. This review focusses on the various treatment options available, with special emphasis on the role of low-level laser therapy (LLLT) in the management of AGA. The literature research considered published journal articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) and reference lists of respective articles. Only articles available in English were considered for this review.
Literatur
1.
Zurück zum Zitat Hamilton JB (1951) Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 53(3):708–728PubMed Hamilton JB (1951) Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 53(3):708–728PubMed
2.
Zurück zum Zitat Otberg N, Finner AM, Shapiro J (2007) Androgenetic Alopecia. Endocrinol Metab Clin N Am 36(2):379–398 Otberg N, Finner AM, Shapiro J (2007) Androgenetic Alopecia. Endocrinol Metab Clin N Am 36(2):379–398
3.
Zurück zum Zitat Paus R, Cotsarelis G. The biology of hair follicles. Epstein FH, editor. N Engl J Med 1999;341(7):491–497 Paus R, Cotsarelis G. The biology of hair follicles. Epstein FH, editor. N Engl J Med 1999;341(7):491–497
4.
Zurück zum Zitat Rousso DE, Kim SW (2014) A review of medical and surgical treatment options for androgenetic alopecia. JAMA Facial Plast Surg 16(6):444PubMed Rousso DE, Kim SW (2014) A review of medical and surgical treatment options for androgenetic alopecia. JAMA Facial Plast Surg 16(6):444PubMed
5.
Zurück zum Zitat Avci P, Gupta GK, Clark J, Wikonkal N, Hamblin MR (2014) Low-level laser (light) therapy (LLLT) for treatment of hair loss: LLLT for hair regrowth. Lasers Surg Med 46(2):144–151PubMed Avci P, Gupta GK, Clark J, Wikonkal N, Hamblin MR (2014) Low-level laser (light) therapy (LLLT) for treatment of hair loss: LLLT for hair regrowth. Lasers Surg Med 46(2):144–151PubMed
6.
Zurück zum Zitat Faghihi G, Mozafarpoor S, Asilian A, Mokhtari F, Esfahani A, Bafandeh B et al (2018) The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia. Indian J Dermatol Venereol Leprol 84(5):547PubMed Faghihi G, Mozafarpoor S, Asilian A, Mokhtari F, Esfahani A, Bafandeh B et al (2018) The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia. Indian J Dermatol Venereol Leprol 84(5):547PubMed
7.
Zurück zum Zitat Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W et al (1998) Finasteride in the treatment of men with androgenetic alopecia. J Am Acad Dermatol 39(4):578–589PubMed Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W et al (1998) Finasteride in the treatment of men with androgenetic alopecia. J Am Acad Dermatol 39(4):578–589PubMed
8.
Zurück zum Zitat Van Neste D, Fuh V, Sanchez-Pedreno P, Lopez-Bran E, Wolff H, Whiting D et al (2000) Finasteride increases anagen hair in men with androgenetic alopecia. Br J Dermatol 143(4):804–810PubMed Van Neste D, Fuh V, Sanchez-Pedreno P, Lopez-Bran E, Wolff H, Whiting D et al (2000) Finasteride increases anagen hair in men with androgenetic alopecia. Br J Dermatol 143(4):804–810PubMed
9.
Zurück zum Zitat Caserini M, Radicioni M, Leuratti C, Terragni E, Iorizzo M, Palmieri R (2016) Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia. Int J Clin Pharmacol Ther 54(01):19–27PubMed Caserini M, Radicioni M, Leuratti C, Terragni E, Iorizzo M, Palmieri R (2016) Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia. Int J Clin Pharmacol Ther 54(01):19–27PubMed
10.
Zurück zum Zitat Irwig MS (2012) Persistent sexual side effects of finasteride: could they be permanent? J Sex Med 9(11):2927–2932PubMed Irwig MS (2012) Persistent sexual side effects of finasteride: could they be permanent? J Sex Med 9(11):2927–2932PubMed
12.
Zurück zum Zitat Hajheydari Z, Akbari J, Saeedi M, Shokoohi L (2009) Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol 75(1):5 Hajheydari Z, Akbari J, Saeedi M, Shokoohi L (2009) Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol 75(1):5
13.
Zurück zum Zitat Drobnis EZ, Nangia AK (2017) 5α-reductase inhibitors (5ARIs) and male reproduction. Adv Exp Med Biol 1034:59–61PubMed Drobnis EZ, Nangia AK (2017) 5α-reductase inhibitors (5ARIs) and male reproduction. Adv Exp Med Biol 1034:59–61PubMed
14.
Zurück zum Zitat Tsunemi Y, Irisawa R, Yoshiie H, Brotherton B, Ito H, Tsuboi R et al (2016) Long-term safety and efficacy of dutasteride in the treatment of male patients with androgenetic alopecia. J Dermatol 43(9):1051–1058PubMed Tsunemi Y, Irisawa R, Yoshiie H, Brotherton B, Ito H, Tsuboi R et al (2016) Long-term safety and efficacy of dutasteride in the treatment of male patients with androgenetic alopecia. J Dermatol 43(9):1051–1058PubMed
15.
Zurück zum Zitat Prager N, Bickett K, French N, Marcovici G (2002) A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 8(2):143–152 Prager N, Bickett K, French N, Marcovici G (2002) A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 8(2):143–152
16.
Zurück zum Zitat Rossi A, Mari E, Scarnò M, Garelli V, Maxia C, Scali E et al (2012) Comparitive effectiveness and finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol 25(4):1167–1173PubMed Rossi A, Mari E, Scarnò M, Garelli V, Maxia C, Scali E et al (2012) Comparitive effectiveness and finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol 25(4):1167–1173PubMed
17.
Zurück zum Zitat Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M (2002) Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience. Dermatol Surg 28(8):678–685PubMed Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M (2002) Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience. Dermatol Surg 28(8):678–685PubMed
18.
Zurück zum Zitat Rathnayake D, Sinclair R (2010) Male androgenetic alopecia. Expert Opin Pharmacother 11(8):1295–1304PubMed Rathnayake D, Sinclair R (2010) Male androgenetic alopecia. Expert Opin Pharmacother 11(8):1295–1304PubMed
19.
Zurück zum Zitat Goren A, Sharma A, Dhurat R, Shapiro J, Sinclair R, Situm M et al (2018) Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients. Dermatol Ther 31(6):e12741PubMed Goren A, Sharma A, Dhurat R, Shapiro J, Sinclair R, Situm M et al (2018) Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients. Dermatol Ther 31(6):e12741PubMed
20.
Zurück zum Zitat Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S (2012) Minoxidil use in dermatology, side effects and recent patents. Recent Patents Inflamm Allergy Drug Discov 6(2):130–136 Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S (2012) Minoxidil use in dermatology, side effects and recent patents. Recent Patents Inflamm Allergy Drug Discov 6(2):130–136
21.
Zurück zum Zitat Bienová M, Kuerová R, Fiurá M (2005) Androgenetic alopecia and current methods of treatment. Androg Alopecia 14(1):4 Bienová M, Kuerová R, Fiurá M (2005) Androgenetic alopecia and current methods of treatment. Androg Alopecia 14(1):4
22.
Zurück zum Zitat Senel E, Purnak T, Sahin C (2011) Liquid formulation of minoxidil versus its foam formulation. Indian J Dermatol 56(4):462PubMedPubMedCentral Senel E, Purnak T, Sahin C (2011) Liquid formulation of minoxidil versus its foam formulation. Indian J Dermatol 56(4):462PubMedPubMedCentral
23.
Zurück zum Zitat Blumeyer A, Tosti A, Messenger A, Reygagne P, del Marmol V, Spuls PI et al (2011) Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. JDDG J Dtsch Dermatol Ges 9:S1–S57PubMed Blumeyer A, Tosti A, Messenger A, Reygagne P, del Marmol V, Spuls PI et al (2011) Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. JDDG J Dtsch Dermatol Ges 9:S1–S57PubMed
24.
Zurück zum Zitat Gupta AK, Charrette A (2015) Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia. Skinmed. 13(3):185–189PubMed Gupta AK, Charrette A (2015) Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia. Skinmed. 13(3):185–189PubMed
25.
Zurück zum Zitat Chitalia J, Dhurat R, Goren A, McCoy J, Kovacevic M, Situm M et al (2018) Characterization of follicular minoxidil sulfotransferase activity in a cohort of pattern hair loss patients from the Indian subcontinent. Dermatol Ther 31(6):e12688PubMed Chitalia J, Dhurat R, Goren A, McCoy J, Kovacevic M, Situm M et al (2018) Characterization of follicular minoxidil sulfotransferase activity in a cohort of pattern hair loss patients from the Indian subcontinent. Dermatol Ther 31(6):e12688PubMed
26.
Zurück zum Zitat Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z et al (2015) Clinical utility and validity of minoxidil response testing in androgenetic alopecia. Dermatol Ther 28(1):13–16PubMed Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z et al (2015) Clinical utility and validity of minoxidil response testing in androgenetic alopecia. Dermatol Ther 28(1):13–16PubMed
27.
Zurück zum Zitat Li ZJ, Choi H-I, Choi D-K, Sohn K-C, Im M, Seo Y-J et al (2012) Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg 38(7pt1):1040–1046PubMed Li ZJ, Choi H-I, Choi D-K, Sohn K-C, Im M, Seo Y-J et al (2012) Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg 38(7pt1):1040–1046PubMed
28.
Zurück zum Zitat Lotti T, Goren A, Verner I, D’Alessio PA, Franca K (2019) Platelet rich plasma in androgenetic alopecia: a systematic review. Dermatol Ther 32(3):e12837PubMed Lotti T, Goren A, Verner I, D’Alessio PA, Franca K (2019) Platelet rich plasma in androgenetic alopecia: a systematic review. Dermatol Ther 32(3):e12837PubMed
29.
Zurück zum Zitat Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG et al (2014) The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int 2014:1–9 Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG et al (2014) The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int 2014:1–9
30.
Zurück zum Zitat Puig CJ, Reese R, Peters M (2016) Double-blind, Placebo-controlled pilot study on the use of platelet-rich plasma in women with female androgenetic alopecia. Dermatol Surg 42(11):1243–1247PubMed Puig CJ, Reese R, Peters M (2016) Double-blind, Placebo-controlled pilot study on the use of platelet-rich plasma in women with female androgenetic alopecia. Dermatol Surg 42(11):1243–1247PubMed
31.
Zurück zum Zitat Ayatollahi A, Hosseini H, Shahdi M, AhmadNasrollahi S, NassiriKashani M, Yadangi S et al (2017) Platelet-rich plasma by single spin process in male pattern androgenetic alopecia: is it an effective treatment? Indian Dermatol Online J 8(6):460–464PubMedPubMedCentral Ayatollahi A, Hosseini H, Shahdi M, AhmadNasrollahi S, NassiriKashani M, Yadangi S et al (2017) Platelet-rich plasma by single spin process in male pattern androgenetic alopecia: is it an effective treatment? Indian Dermatol Online J 8(6):460–464PubMedPubMedCentral
32.
Zurück zum Zitat Stevens J, Khetarpal S (2019) Platelet-rich plasma for androgenetic alopecia: a review of the literature and proposed treatment protocol. Int J Womens Dermatol 5(1):46–51PubMed Stevens J, Khetarpal S (2019) Platelet-rich plasma for androgenetic alopecia: a review of the literature and proposed treatment protocol. Int J Womens Dermatol 5(1):46–51PubMed
33.
34.
Zurück zum Zitat Rossi A, Anzalone A, Fortuna MC, Caro G, Garelli V, Pranteda G et al (2016) Multi-therapies in androgenetic alopecia: review and clinical experiences: an update and future potential treatments. Dermatol Ther 29(6):424–432PubMed Rossi A, Anzalone A, Fortuna MC, Caro G, Garelli V, Pranteda G et al (2016) Multi-therapies in androgenetic alopecia: review and clinical experiences: an update and future potential treatments. Dermatol Ther 29(6):424–432PubMed
35.
Zurück zum Zitat Patwardhan N, Mysore V (2008) Hair transplantation: standard guidelines of care. Indian J Dermatol Venereol Leprol 74(Suppl):S46–53 Patwardhan N, Mysore V (2008) Hair transplantation: standard guidelines of care. Indian J Dermatol Venereol Leprol 74(Suppl):S46–53
36.
Zurück zum Zitat Kassimir JJ (1987) Use of topical minoxidil as a possible adjunct to hair transplant surgery. J Am Acad Dermatol 16(3):685–687PubMed Kassimir JJ (1987) Use of topical minoxidil as a possible adjunct to hair transplant surgery. J Am Acad Dermatol 16(3):685–687PubMed
37.
Zurück zum Zitat Leavitt M, David P-M, Rao NA, Barusco M, Kaufman KD, Ziering C (2006) Effects of finasteride (1 mg) on hair transplant. Dermatol Surg 31(10):1268–1276 Leavitt M, David P-M, Rao NA, Barusco M, Kaufman KD, Ziering C (2006) Effects of finasteride (1 mg) on hair transplant. Dermatol Surg 31(10):1268–1276
38.
Zurück zum Zitat Dhurat R, Mathapati S (2015) Response to microneedling treatment in men with androgenetic alopecia who failed to respond to conventional therapy. Indian J Dermatol 60(3):260PubMedPubMedCentral Dhurat R, Mathapati S (2015) Response to microneedling treatment in men with androgenetic alopecia who failed to respond to conventional therapy. Indian J Dermatol 60(3):260PubMedPubMedCentral
39.
Zurück zum Zitat Verner I, Lotti T (2018) Clinical evaluation of a novel fractional radiofrequency device for hair growth: fractional radiofrequency for hair growth stimulation. Dermatol Ther 31(3):e12590PubMed Verner I, Lotti T (2018) Clinical evaluation of a novel fractional radiofrequency device for hair growth: fractional radiofrequency for hair growth stimulation. Dermatol Ther 31(3):e12590PubMed
40.
Zurück zum Zitat Maddin WS, Bell PW, James JH (1990) The biological effects of a pulsed electrostatic field with specific reference to hair. Electrotrichogenesis Int J Dermatol 29(6):446–450PubMed Maddin WS, Bell PW, James JH (1990) The biological effects of a pulsed electrostatic field with specific reference to hair. Electrotrichogenesis Int J Dermatol 29(6):446–450PubMed
41.
Zurück zum Zitat Doghaim NN, El-Tatawy RA, Neinaa YME, Abd El-Samd MM (2018) Study of the efficacy of carboxytherapy in alopecia. J Cosmet Dermatol 17(6):1275–1285PubMed Doghaim NN, El-Tatawy RA, Neinaa YME, Abd El-Samd MM (2018) Study of the efficacy of carboxytherapy in alopecia. J Cosmet Dermatol 17(6):1275–1285PubMed
42.
Zurück zum Zitat Ghanaat M (2010) Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. South Med J 103(9):917–921PubMed Ghanaat M (2010) Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. South Med J 103(9):917–921PubMed
43.
Zurück zum Zitat Jimenez JJ, Wikramanayake TC, Bergfeld W, Hordinsky M, Hickman JG, Hamblin MR et al (2014) Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, Double-blind Study. Am J Clin Dermatol 15(2):115–127PubMedPubMedCentral Jimenez JJ, Wikramanayake TC, Bergfeld W, Hordinsky M, Hickman JG, Hamblin MR et al (2014) Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, Double-blind Study. Am J Clin Dermatol 15(2):115–127PubMedPubMedCentral
44.
Zurück zum Zitat Kruglikov IL, Zhang Z, Scherer PE (2019) The role of immature and mature adipocytes in hair cycling. Trends Endocrinol Metab 30(2):93–105PubMed Kruglikov IL, Zhang Z, Scherer PE (2019) The role of immature and mature adipocytes in hair cycling. Trends Endocrinol Metab 30(2):93–105PubMed
45.
Zurück zum Zitat Leavitt M, Charles G, Heyman E, Michaels D (2009) HairMax LaserComb® laser phototherapy device in the treatment of male androgenetic alopecia: a randomized, double-blind, sham device-controlled. Multicentre Trial Clin Drug Investig 29(5):283–292PubMed Leavitt M, Charles G, Heyman E, Michaels D (2009) HairMax LaserComb® laser phototherapy device in the treatment of male androgenetic alopecia: a randomized, double-blind, sham device-controlled. Multicentre Trial Clin Drug Investig 29(5):283–292PubMed
46.
Zurück zum Zitat Kim H, Choi JW, Kim JY, Shin JW, Lee S, Huh C-H (2013) Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, Sham Device–Controlled Multicenter Trial. Dermatol Surg 39(8):1177–1183PubMed Kim H, Choi JW, Kim JY, Shin JW, Lee S, Huh C-H (2013) Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, Sham Device–Controlled Multicenter Trial. Dermatol Surg 39(8):1177–1183PubMed
47.
Zurück zum Zitat Suchonwanit P, Chalermroj N, Khunkhet S (2019) Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial. Lasers Med Sci 34(6):1107–1114PubMed Suchonwanit P, Chalermroj N, Khunkhet S (2019) Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial. Lasers Med Sci 34(6):1107–1114PubMed
48.
Zurück zum Zitat Mai-Yi Fan S, Cheng Y-P, Lee M-Y, Lin S-J, Chiu H-Y (2018) Efficacy and safety of a low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, self-comparison, sham device-controlled trial. Dermatol Surg Off Publ Am Soc Dermatol Surg Al 44(11):1411–1420 Mai-Yi Fan S, Cheng Y-P, Lee M-Y, Lin S-J, Chiu H-Y (2018) Efficacy and safety of a low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, self-comparison, sham device-controlled trial. Dermatol Surg Off Publ Am Soc Dermatol Surg Al 44(11):1411–1420
49.
Zurück zum Zitat Lanzafame RJ, Blanche RR, Bodian AB, Chiacchierini RP, Fernandez-Obregon A, Kazmirek ER (2013) The growth of human scalp hair mediated by visible red light laser and LED sources in males: the growth of human scalp hair. Lasers Surg Med 45(8):487–495PubMed Lanzafame RJ, Blanche RR, Bodian AB, Chiacchierini RP, Fernandez-Obregon A, Kazmirek ER (2013) The growth of human scalp hair mediated by visible red light laser and LED sources in males: the growth of human scalp hair. Lasers Surg Med 45(8):487–495PubMed
50.
Zurück zum Zitat Lanzafame RJ, Blanche RR, Chiacchierini RP, Kazmirek ER, Sklar JA (2014) The growth of human scalp hair in females using visible red light laser and LED sources: growth of scalp hair in women. Lasers Surg Med 46(8):601–607PubMed Lanzafame RJ, Blanche RR, Chiacchierini RP, Kazmirek ER, Sklar JA (2014) The growth of human scalp hair in females using visible red light laser and LED sources: growth of scalp hair in women. Lasers Surg Med 46(8):601–607PubMed
Metadaten
Titel
Low-level laser therapy and narrative review of other treatment modalities in androgenetic alopecia
verfasst von
Hassan Galadari
Swathi Shivakumar
Torello Lotti
Uwe Wollina
Andy Goren
Ghasem Rahmatpour Rokni
Stephan Grabbe
Mohamad Goldust
Publikationsdatum
11.03.2020
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 6/2020
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-020-02994-4

Weitere Artikel der Ausgabe 6/2020

Lasers in Medical Science 6/2020 Zur Ausgabe